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'''Tyrosine-protein kinase ABL2''' also known as''' Abelson-related gene ''' (Arg) is an [[enzyme]] that in humans is encoded by the ''ABL2'' [[gene]].<ref name="pmid3787260">{{cite journal | vauthors = Kruh GD, King CR, Kraus MH, Popescu NC, Amsbaugh SC, McBride WO, Aaronson SA | author7-link = Stuart A. Aaronson | title = A novel human gene closely related to the abl proto-oncogene | journal = Science | volume = 234 | issue = 4783 | pages = 1545–8 |date=Jan 1987 | pmid = 3787260 | pmc =  | doi =10.1126/science.3787260  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27| accessdate = }}</ref>
== Function ==
ABL2 is a cytoplasmic [[tyrosine kinase]] which is closely related to but distinct from [[Abl gene|ABL1]].  The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the [[SH2 domain|SH2]] and [[SH3 domain|SH3]] domains.  ABL2 is expressed in both normal and tumor cells. The expression of ABL2 gene is higher in KRAS mutant non-small cell lung cancer.<ref>{{Cite journal|last=Nagy|first=Ádám|last2=Pongor|first2=Lőrinc Sándor|last3=Szabó|first3=András|last4=Santarpia|first4=Mariacarmela|last5=Győrffy|first5=Balázs|date=2017-02-15|title=KRAS driven expression signature has prognostic power superior to mutation status in non-small cell lung cancer|journal=International Journal of Cancer|volume=140|issue=4|pages=930–937|doi=10.1002/ijc.30509|issn=1097-0215|pmc=5299512|pmid=27859136}}</ref> The ABL2 gene product is expressed as two variants bearing different amino termini, both approximately 12-kb in length.<ref name="entrez"/>
== Interactions ==
ABL2 has been shown to [[Protein-protein interaction|interact]] with three proteins: [[Abl gene]],<ref name="pmid12569093">{{cite journal |vauthors=Cao C, Leng Y, Li C, Kufe D | title = Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response | journal = J. Biol. Chem. | volume = 278 | issue = 15 | pages = 12961–7 |date=April 2003 | pmid = 12569093 | doi = 10.1074/jbc.M300058200 | url = | issn = }}</ref> [[catalase]],<ref name="pmid12777400">{{cite journal |vauthors=Cao C, Leng Y, Kufe D | title = Catalase activity is regulated by c-Abl and Arg in the oxidative stress response | journal = J. Biol. Chem. | volume = 278 | issue = 32 | pages = 29667–75 |date=August 2003 | pmid = 12777400 | doi = 10.1074/jbc.M301292200 | url = | issn = }}</ref> and [[SORBS2]].<ref name="pmid9211900">{{cite journal |vauthors=Wang B, Golemis EA, Kruh GD | title = ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks | journal = J. Biol. Chem. | volume = 272 | issue = 28 | pages = 17542–50 |date=July 1997 | pmid = 9211900 | doi = 10.1074/jbc.272.28.17542| url = | issn = }}</ref> The protein Abl gene is also known as abelson murine leukemia viral oncogene homolog 1 and is a protein that is encoded by the human ABL1 gene.<ref name="pmid1857987">{{cite journal |vauthors=Szczylik C, Skorski T, Nicolaides NC, Manzella L, Malaguarnera L, Venturelli D, Gewirtz AM, Calabretta B | title = Selective inhibition of leukemia cell proliferation by BCR-ABL antisense oligodeoxynucleotides | journal = Science | volume = 253 | issue = 5019 | pages = 562–5 |date=August 1991 | pmid = 1857987 | doi = 10.1126/science.1857987 }}</ref> Catalase is a common [[enzyme]] that [[catalyst|catalyzes]] the decomposition of [[hydrogen peroxide]] to [[water]] and [[oxygen]].<ref name="pmid14745498">{{cite journal |vauthors=Chelikani P, Fita I, Loewen PC | title = Diversity of structures and properties among catalases | journal = Cell. Mol. Life Sci. | volume = 61 | issue = 2 | pages = 192–208 | date = January 2004 | pmid = 14745498 | doi = 10.1007/s00018-003-3206-5 | url =  }}</ref> SORBS2 is also known as Sorbin and SH3 domain-containing protein 2 and is a protein encoded by the SORBS2 [[gene]] in humans.<ref name="entrez" /><ref name="pmid9211900" /><ref name="pmid9872452">{{cite journal |vauthors=Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res | volume = 5 | issue = 5 | pages = 277–86 |date=Apr 1999 | pmid = 9872452 | pmc =  | doi =10.1093/dnares/5.5.277  }}</ref>
== References ==
{{reflist}}
== Further reading ==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | vauthors=Bradley WD, Koleske AJ |title=Regulation of cell migration and morphogenesis by Abl-family kinases: emerging mechanisms and physiological contexts. |journal=J Cell Sci |volume=122 |pages=3441–54 |year=2009 |pmid=19759284 |doi=10.1242/jcs.039859 |pmc=2746129}}
*{{cite journal  | author=Pendergast AM |title=The Abl family kinases: mechanisms of regulation and signaling. |journal=Adv. Cancer Res. |volume=85 |issue=  |pages= 51–100 |year= 2003 |pmid= 12374288 |doi=10.1016/S0065-230X(02)85003-5  }}
*{{cite journal  |vauthors=Muller AJ, Pendergast AM, Havlik MH |title=A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction. |journal=Mol. Cell. Biol. |volume=12 |issue= 11 |pages= 5087–93 |year= 1992 |pmid= 1383690 |doi=  | pmc=360442  |display-authors=etal}}
*{{cite journal  |vauthors=Kruh GD, Perego R, Miki T, Aaronson SA |title=The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 15 |pages= 5802–6 |year= 1990 |pmid= 2198571 |doi=10.1073/pnas.87.15.5802  | pmc=54416  }}
*{{cite journal  |vauthors=Kruh GD, King CR, Kraus MH |title=A novel human gene closely related to the abl proto-oncogene. |journal=Science |volume=234 |issue= 4783 |pages= 1545–8 |year= 1987 |pmid= 3787260 |doi=10.1126/science.3787260  |display-authors=etal}}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
*{{cite journal  |vauthors=Wang B, Kruh GD |title=Subcellular localization of the Arg protein tyrosine kinase |journal=Oncogene |volume=13 |issue= 1 |pages= 193–7 |year= 1996 |pmid= 8700546 |doi=  }}
*{{cite journal  |vauthors=Wang B, Mysliwiec T, Feller SM |title=Proline-rich sequences mediate the interaction of the Arg protein tyrosine kinase with Crk |journal=Oncogene |volume=13 |issue= 7 |pages= 1379–85 |year= 1996 |pmid= 8875975 |doi=  |display-authors=etal}}
*{{cite journal  |vauthors=Wang B, Golemis EA, Kruh GD |title=ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks |journal=J. Biol. Chem. |volume=272 |issue= 28 |pages= 17542–50 |year= 1997 |pmid= 9211900 |doi=10.1074/jbc.272.28.17542  }}
*{{cite journal  |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  |display-authors=etal}}
*{{cite journal  |vauthors=Koval AP, Blakesley VA, Roberts CT |title=Interaction in vitro of the product of the c-Crk-II proto-oncogene with the insulin-like growth factor I receptor |journal=Biochem. J. |volume=330 |issue=  2|pages= 923–32 |year= 1998 |pmid= 9480911 |doi=  | pmc=1219226  |display-authors=etal}}
*{{cite journal  |vauthors=Hashimoto Y, Katayama H, Kiyokawa E |title=Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor |journal=J. Biol. Chem. |volume=273 |issue= 27 |pages= 17186–91 |year= 1998 |pmid= 9642287 |doi=10.1074/jbc.273.27.17186  |display-authors=etal}}
*{{cite journal  |vauthors=Danial NN, Losman JA, Lu T |title=Direct interaction of Jak1 and v-Abl is required for v-Abl-induced activation of STATs and proliferation |journal=Mol. Cell. Biol. |volume=18 |issue= 11 |pages= 6795–804 |year= 1998 |pmid= 9774693 |doi=  | pmc=109263  |display-authors=etal}}
*{{cite journal  |vauthors=Cao C, Ren X, Kharbanda S |title=The ARG tyrosine kinase interacts with Siva-1 in the apoptotic response to oxidative stress |journal=J. Biol. Chem. |volume=276 |issue= 15 |pages= 11465–8 |year= 2001 |pmid= 11278261 |doi= 10.1074/jbc.C100050200 |display-authors=etal}}
*{{cite journal  |vauthors=Yu HH, Zisch AH, Dodelet VC, Pasquale EB |title=Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor |journal=Oncogene |volume=20 |issue= 30 |pages= 3995–4006 |year= 2001 |pmid= 11494128 |doi= 10.1038/sj.onc.1204524 }}
*{{cite journal  |vauthors=Endo A, Nagashima K, Kurose H |title=Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkII |journal=J. Biol. Chem. |volume=277 |issue= 26 |pages= 23747–54 |year= 2002 |pmid= 11956190 |doi= 10.1074/jbc.M111794200 |display-authors=etal}}
*{{cite journal  |vauthors=Abassi YA, Vuori K |title=Tyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling |journal=EMBO J. |volume=21 |issue= 17 |pages= 4571–82 |year= 2002 |pmid= 12198159 |doi=10.1093/emboj/cdf446  | pmc=126186  }}
*{{cite journal  |vauthors=Bianchi C, Muradore I, Corizzato M |title=The expression of the non-receptor tyrosine kinases Arg and c-abl is differently modulated in B lymphoid cells at different stages of differentiation |journal=FEBS Lett. |volume=527 |issue= 1–3 |pages= 216–222 |year= 2002 |pmid= 12220663 |doi=10.1016/S0014-5793(02)03233-7  |display-authors=etal}}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  |vauthors=Salomon AR, Ficarro SB, Brill LM |title=Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 2 |pages= 443–8 |year= 2003 |pmid= 12522270 |doi= 10.1073/pnas.2436191100  | pmc=141014 |display-authors=etal}}
}}
{{refend}}
==External links==
* {{MeshName|Genes,+abl}}
* {{MeshName|Abelson+Leukemia+Virus}}
* [https://web.archive.org/web/20110704224355/http://cmkb.cellmigration.org/report.cgi?report=orth_overview&gene_id=27 ABL2] Info with links in the [http://www.cellmigration.org/index.shtml Cell Migration Gateway]
* {{UCSC gene info|ABL2}}
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{{PDB Gallery|geneid=27}}
{{GNF_Protein_box
{{Tyrosine kinases}}
| image = PBB_Protein_ABL2_image.jpg
{{Enzymes}}
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ab2.
{{Portal bar|Molecular and Cellular Biology|border=no}}
| PDB = {{PDB2|1ab2}}, {{PDB2|1abo}}, {{PDB2|1abq}}, {{PDB2|1bbz}}, {{PDB2|1fpu}}, {{PDB2|1iep}}, {{PDB2|1ju5}}, {{PDB2|1m52}}, {{PDB2|1opj}}, {{PDB2|2e2b}}, {{PDB2|2f4j}}, {{PDB2|2g1t}}, {{PDB2|2g2f}}, {{PDB2|2g2h}}, {{PDB2|2g2i}}, {{PDB2|2gqg}}, {{PDB2|2hiw}}, {{PDB2|2hyy}}, {{PDB2|2hz0}}, {{PDB2|2hz4}}, {{PDB2|2hzi}}, {{PDB2|2hzn}}
| Name = V-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)
| HGNCid = 77
| Symbol = ABL2
| AltSymbols =; ABLL; ARG
| OMIM = 164690
| ECnumber = 
| Homologene = 5278
| MGIid = 87860
| GeneAtlas_image1 = PBB_GE_ABL2_206411_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0030145 |text = manganese ion binding}} {{GNF_GO|id=GO:0035014 |text = phosphoinositide 3-kinase regulator activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005942 |text = phosphoinositide 3-kinase complex}} {{GNF_GO|id=GO:0015629 |text = actin cytoskeleton}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0018108 |text = peptidyl-tyrosine phosphorylation}} {{GNF_GO|id=GO:0051017 |text = actin filament bundle formation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 27
    | Hs_Ensembl = ENSG00000143322
    | Hs_RefseqProtein = NP_005149
    | Hs_RefseqmRNA = NM_005158
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 177339806
    | Hs_GenLoc_end = 177465359
    | Hs_Uniprot = P42684
    | Mm_EntrezGene = 11352
    | Mm_Ensembl = ENSMUSG00000026596
    | Mm_RefseqmRNA = NM_009595
    | Mm_RefseqProtein = NP_033725
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 158395726
    | Mm_GenLoc_end = 158479393
    | Mm_Uniprot = Q61055
  }}
}}
'''V-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)''', also known as '''ABL2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27| accessdate = }}</ref>
 
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = ABL2 is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1.  The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains.  ABL2 is expressed in both normal and tumor cells.  The ABL2 gene product is expressed as two variants bearing different amino termini, both approximately 12-kb in length.<ref name="entrez">{{cite web | title = Entrez Gene: ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27| accessdate = }}</ref>
}}
 
==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Pendergast AM |title=The Abl family kinases: mechanisms of regulation and signaling. |journal=Adv. Cancer Res. |volume=85 |issue=  |pages= 51-100 |year= 2003 |pmid= 12374288 |doi=  }}
*{{cite journal  | author=Muller AJ, Pendergast AM, Havlik MH, ''et al.'' |title=A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction. |journal=Mol. Cell. Biol. |volume=12 |issue= 11 |pages= 5087-93 |year= 1992 |pmid= 1383690 |doi=  }}
*{{cite journal  | author=Kruh GD, Perego R, Miki T, Aaronson SA |title=The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 15 |pages= 5802-6 |year= 1990 |pmid= 2198571 |doi=  }}
*{{cite journal  | author=Kruh GD, King CR, Kraus MH, ''et al.'' |title=A novel human gene closely related to the abl proto-oncogene. |journal=Science |volume=234 |issue= 4783 |pages= 1545-8 |year= 1987 |pmid= 3787260 |doi=  }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | author=Wang B, Kruh GD |title=Subcellular localization of the Arg protein tyrosine kinase. |journal=Oncogene |volume=13 |issue= 1 |pages= 193-7 |year= 1996 |pmid= 8700546 |doi=  }}
*{{cite journal  | author=Wang B, Mysliwiec T, Feller SM, ''et al.'' |title=Proline-rich sequences mediate the interaction of the Arg protein tyrosine kinase with Crk. |journal=Oncogene |volume=13 |issue= 7 |pages= 1379-85 |year= 1996 |pmid= 8875975 |doi=  }}
*{{cite journal  | author=Wang B, Golemis EA, Kruh GD |title=ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks. |journal=J. Biol. Chem. |volume=272 |issue= 28 |pages= 17542-50 |year= 1997 |pmid= 9211900 |doi=  }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | author=Koval AP, Blakesley VA, Roberts CT, ''et al.'' |title=Interaction in vitro of the product of the c-Crk-II proto-oncogene with the insulin-like growth factor I receptor. |journal=Biochem. J. |volume=330 ( Pt 2) |issue=  |pages= 923-32 |year= 1998 |pmid= 9480911 |doi=  }}
*{{cite journal  | author=Hashimoto Y, Katayama H, Kiyokawa E, ''et al.'' |title=Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor. |journal=J. Biol. Chem. |volume=273 |issue= 27 |pages= 17186-91 |year= 1998 |pmid= 9642287 |doi=  }}
*{{cite journal  | author=Danial NN, Losman JA, Lu T, ''et al.'' |title=Direct interaction of Jak1 and v-Abl is required for v-Abl-induced activation of STATs and proliferation. |journal=Mol. Cell. Biol. |volume=18 |issue= 11 |pages= 6795-804 |year= 1998 |pmid= 9774693 |doi=  }}
*{{cite journal  | author=Cao C, Ren X, Kharbanda S, ''et al.'' |title=The ARG tyrosine kinase interacts with Siva-1 in the apoptotic response to oxidative stress. |journal=J. Biol. Chem. |volume=276 |issue= 15 |pages= 11465-8 |year= 2001 |pmid= 11278261 |doi= 10.1074/jbc.C100050200 }}
*{{cite journal  | author=Yu HH, Zisch AH, Dodelet VC, Pasquale EB |title=Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor. |journal=Oncogene |volume=20 |issue= 30 |pages= 3995-4006 |year= 2001 |pmid= 11494128 |doi= 10.1038/sj.onc.1204524 }}
*{{cite journal  | author=Endo A, Nagashima K, Kurose H, ''et al.'' |title=Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkII. |journal=J. Biol. Chem. |volume=277 |issue= 26 |pages= 23747-54 |year= 2002 |pmid= 11956190 |doi= 10.1074/jbc.M111794200 }}
*{{cite journal  | author=Abassi YA, Vuori K |title=Tyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling. |journal=EMBO J. |volume=21 |issue= 17 |pages= 4571-82 |year= 2002 |pmid= 12198159 |doi=  }}
*{{cite journal  | author=Bianchi C, Muradore I, Corizzato M, ''et al.'' |title=The expression of the non-receptor tyrosine kinases Arg and c-abl is differently modulated in B lymphoid cells at different stages of differentiation. |journal=FEBS Lett. |volume=527 |issue= 1-3 |pages= 216-222 |year= 2002 |pmid= 12220663 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Salomon AR, Ficarro SB, Brill LM, ''et al.'' |title=Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 2 |pages= 443-8 |year= 2003 |pmid= 12522270 |doi= 10.1073/pnas.2436191100 }}
}}
{{refend}}


{{protein-stub}}
{{DEFAULTSORT:Abl2}}
{{WikiDoc Sources}}
[[Category:Tyrosine kinases]]
[[Category:Oncogenes]]

Revision as of 17:36, 5 December 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
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View/Edit Human

Tyrosine-protein kinase ABL2 also known as Abelson-related gene (Arg) is an enzyme that in humans is encoded by the ABL2 gene.[1][2]

Function

ABL2 is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and tumor cells. The expression of ABL2 gene is higher in KRAS mutant non-small cell lung cancer.[3] The ABL2 gene product is expressed as two variants bearing different amino termini, both approximately 12-kb in length.[2]

Interactions

ABL2 has been shown to interact with three proteins: Abl gene,[4] catalase,[5] and SORBS2.[6] The protein Abl gene is also known as abelson murine leukemia viral oncogene homolog 1 and is a protein that is encoded by the human ABL1 gene.[7] Catalase is a common enzyme that catalyzes the decomposition of hydrogen peroxide to water and oxygen.[8] SORBS2 is also known as Sorbin and SH3 domain-containing protein 2 and is a protein encoded by the SORBS2 gene in humans.[2][6][9]

References

  1. ↑ Kruh GD, King CR, Kraus MH, Popescu NC, Amsbaugh SC, McBride WO, Aaronson SA (Jan 1987). "A novel human gene closely related to the abl proto-oncogene". Science. 234 (4783): 1545–8. doi:10.1126/science.3787260. PMID 3787260.
  2. ↑ 2.0 2.1 2.2 "Entrez Gene: ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)".
  3. ↑ Nagy, Ádám; Pongor, Lőrinc Sándor; Szabó, András; Santarpia, Mariacarmela; Győrffy, Balázs (2017-02-15). "KRAS driven expression signature has prognostic power superior to mutation status in non-small cell lung cancer". International Journal of Cancer. 140 (4): 930–937. doi:10.1002/ijc.30509. ISSN 1097-0215. PMC 5299512. PMID 27859136.
  4. ↑ Cao C, Leng Y, Li C, Kufe D (April 2003). "Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response". J. Biol. Chem. 278 (15): 12961–7. doi:10.1074/jbc.M300058200. PMID 12569093.
  5. ↑ Cao C, Leng Y, Kufe D (August 2003). "Catalase activity is regulated by c-Abl and Arg in the oxidative stress response". J. Biol. Chem. 278 (32): 29667–75. doi:10.1074/jbc.M301292200. PMID 12777400.
  6. ↑ 6.0 6.1 Wang B, Golemis EA, Kruh GD (July 1997). "ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks". J. Biol. Chem. 272 (28): 17542–50. doi:10.1074/jbc.272.28.17542. PMID 9211900.
  7. ↑ Szczylik C, Skorski T, Nicolaides NC, Manzella L, Malaguarnera L, Venturelli D, Gewirtz AM, Calabretta B (August 1991). "Selective inhibition of leukemia cell proliferation by BCR-ABL antisense oligodeoxynucleotides". Science. 253 (5019): 562–5. doi:10.1126/science.1857987. PMID 1857987.
  8. ↑ Chelikani P, Fita I, Loewen PC (January 2004). "Diversity of structures and properties among catalases". Cell. Mol. Life Sci. 61 (2): 192–208. doi:10.1007/s00018-003-3206-5. PMID 14745498.
  9. ↑ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.

Further reading

External links


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