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{{Infobox_gene}}
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'''Proto-oncogene tyrosine-protein kinase MER''' is an [[enzyme]] that in humans is encoded by the ''MERTK'' [[gene]].<ref name="pmid8086340">{{cite journal | vauthors = Graham DK, Dawson TL, Mullaney DL, Snodgrass HR, Earp HS | title = Cloning and mRNA expression analysis of a novel human protooncogene, c-mer | journal = Cell Growth & Differentiation | volume = 5 | issue = 6 | pages = 647–57 | date = June 1994 | pmid = 8086340 | pmc =  | doi =  }}</ref><ref name="pmid10343112">{{cite journal | vauthors = Weier HU, Fung J, Lersch RA | title = Assignment of protooncogene MERTK (a.k.a. c-mer) to human chromosome 2q14.1 by in situ hybridization | journal = Cytogenetics and Cell Genetics | volume = 84 | issue = 1-2 | pages = 91–2 | date = Jun 1999 | pmid = 10343112 | pmc =  | doi = 10.1159/000015223 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MERTK c-mer proto-oncogene tyrosine kinase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10461| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_MERTK_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2dbj.
| PDB = {{PDB2|2dbj}}, {{PDB2|2p0c}}
| Name = C-mer proto-oncogene tyrosine kinase
| HGNCid = 7027
| Symbol = MERTK
| AltSymbols =; MER; MGC133349; c-mer
| OMIM = 604705
| ECnumber = 
| Homologene = 4626
| MGIid = 96965
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004714 |text = transmembrane receptor protein tyrosine kinase activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10461
    | Hs_Ensembl = ENSG00000153208
    | Hs_RefseqProtein = NP_006334
    | Hs_RefseqmRNA = NM_006343
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 112372662
    | Hs_GenLoc_end = 112503413
    | Hs_Uniprot = Q12866
    | Mm_EntrezGene = 17289
    | Mm_Ensembl = ENSMUSG00000014361
    | Mm_RefseqmRNA = XM_001003774
    | Mm_RefseqProtein = XP_001003774
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 128390438
    | Mm_GenLoc_end = 128493629
    | Mm_Uniprot = Q8C584
  }}
}}
'''C-mer proto-oncogene tyrosine kinase''', also known as '''MERTK''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MERTK c-mer proto-oncogene tyrosine kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10461| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene is a member of the TYRO3/AXL/MER (TAM) receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive [[retinitis pigmentosa]] (RP).<ref name="entrez">{{cite web | title = Entrez Gene: MERTK c-mer proto-oncogene tyrosine kinase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10461| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).<ref name="entrez">{{cite web | title = Entrez Gene: MERTK c-mer proto-oncogene tyrosine kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10461| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Iwase T, Tanaka M, Suzuki M, Naito Y, Sugimura H, Kino I | title = Identification of protein-tyrosine kinase genes preferentially expressed in embryo stomach and gastric cancer | journal = Biochemical and Biophysical Research Communications | volume = 194 | issue = 2 | pages = 698–705 | date = July 1993 | pmid = 7688222 | doi = 10.1006/bbrc.1993.1878 }}
| citations =
* {{cite journal | vauthors = Mark MR, Chen J, Hammonds RG, Sadick M, Godowsk PJ | title = Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl | journal = The Journal of Biological Chemistry | volume = 271 | issue = 16 | pages = 9785–9 | date = April 1996 | pmid = 8621659 | doi = 10.1074/jbc.271.16.9785 }}
*{{cite journal | author=Iwase T, Tanaka M, Suzuki M, ''et al.'' |title=Identification of protein-tyrosine kinase genes preferentially expressed in embryo stomach and gastric cancer. |journal=Biochem. Biophys. Res. Commun. |volume=194 |issue= 2 |pages= 698-705 |year= 1993 |pmid= 7688222 |doi= 10.1006/bbrc.1993.1878 }}
* {{cite journal | vauthors = Ling L, Templeton D, Kung HJ | title = Identification of the major autophosphorylation sites of Nyk/Mer, an NCAM-related receptor tyrosine kinase | journal = The Journal of Biological Chemistry | volume = 271 | issue = 31 | pages = 18355–62 | date = August 1996 | pmid = 8702477 | doi = 10.1074/jbc.271.31.18355 }}
*{{cite journal | author=Graham DK, Dawson TL, Mullaney DL, ''et al.'' |title=Cloning and mRNA expression analysis of a novel human protooncogene, c-mer. |journal=Cell Growth Differ. |volume=5 |issue= 6 |pages= 647-57 |year= 1994 |pmid= 8086340 |doi= }}
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = September 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
*{{cite journal | author=Mark MR, Chen J, Hammonds RG, ''et al.'' |title=Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl. |journal=J. Biol. Chem. |volume=271 |issue= 16 |pages= 9785-9 |year= 1996 |pmid= 8621659 |doi= }}
* {{cite journal | vauthors = Nagata K, Ohashi K, Nakano T, Arita H, Zong C, Hanafusa H, Mizuno K | title = Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases | journal = The Journal of Biological Chemistry | volume = 271 | issue = 47 | pages = 30022–7 | date = November 1996 | pmid = 8939948 | doi = 10.1074/jbc.271.47.30022 }}
*{{cite journal | author=Ling L, Templeton D, Kung HJ |title=Identification of the major autophosphorylation sites of Nyk/Mer, an NCAM-related receptor tyrosine kinase. |journal=J. Biol. Chem. |volume=271 |issue= 31 |pages= 18355-62 |year= 1996 |pmid= 8702477 |doi= }}
* {{cite journal | vauthors = Georgescu MM, Kirsch KH, Shishido T, Zong C, Hanafusa H | title = Biological effects of c-Mer receptor tyrosine kinase in hematopoietic cells depend on the Grb2 binding site in the receptor and activation of NF-kappaB | journal = Molecular and Cellular Biology | volume = 19 | issue = 2 | pages = 1171–81 | date = February 1999 | pmid = 9891051 | pmc = 116046 | doi =  }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* {{cite journal | vauthors = Gal A, Li Y, Thompson DA, Weir J, Orth U, Jacobson SG, Apfelstedt-Sylla E, Vollrath D | title = Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa | journal = Nature Genetics | volume = 26 | issue = 3 | pages = 270–1 | date = November 2000 | pmid = 11062461 | doi = 10.1038/81555 }}
*{{cite journal | author=Nagata K, Ohashi K, Nakano T, ''et al.'' |title=Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases. |journal=J. Biol. Chem. |volume=271 |issue= 47 |pages= 30022-7 |year= 1997 |pmid= 8939948 |doi=  }}
* {{cite journal | vauthors = Thompson DA, McHenry CL, Li Y, Richards JE, Othman MI, Schwinger E, Vollrath D, Jacobson SG, Gal A | title = Retinal dystrophy due to paternal isodisomy for chromosome 1 or chromosome 2, with homoallelism for mutations in RPE65 or MERTK, respectively | journal = American Journal of Human Genetics | volume = 70 | issue = 1 | pages = 224–9 | date = January 2002 | pmid = 11727200 | pmc = 384890 | doi = 10.1086/338455 }}
*{{cite journal | author=Georgescu MM, Kirsch KH, Shishido T, ''et al.'' |title=Biological effects of c-Mer receptor tyrosine kinase in hematopoietic cells depend on the Grb2 binding site in the receptor and activation of NF-kappaB. |journal=Mol. Cell. Biol. |volume=19 |issue= 2 |pages= 1171-81 |year= 1999 |pmid= 9891051 |doi= }}
* {{cite journal | vauthors = Yin JL, Hambly BD, Bao SS, Painter D, Bishop GA, Eris JM | title = Expression of growth arrest-specific gene 6 and its receptors in dysfunctional human renal allografts | journal = Transplant International | volume = 16 | issue = 9 | pages = 681–8 | date = September 2003 | pmid = 12768229 | doi = 10.1007/s00147-003-0593-3 }}
*{{cite journal | author=Weier HU, Fung J, Lersch RA |title=Assignment of protooncogene MERTK (a.k.a. c-mer) to human chromosome 2q14.1 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=84 |issue= 1-2 |pages= 91-2 |year= 1999 |pmid= 10343112 |doi= }}
* {{cite journal | vauthors = McHenry CL, Liu Y, Feng W, Nair AR, Feathers KL, Ding X, Gal A, Vollrath D, Sieving PA, Thompson DA | title = MERTK arginine-844-cysteine in a patient with severe rod-cone dystrophy: loss of mutant protein function in transfected cells | journal = Investigative Ophthalmology & Visual Science | volume = 45 | issue = 5 | pages = 1456–63 | date = May 2004 | pmid = 15111602 | doi = 10.1167/iovs.03-0909 }}
*{{cite journal | author=Gal A, Li Y, Thompson DA, ''et al.'' |title=Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa. |journal=Nat. Genet. |volume=26 |issue= 3 |pages= 270-1 |year= 2000 |pmid= 11062461 |doi= 10.1038/81555 }}
* {{cite journal | vauthors = Chen C, Li Q, Darrow AL, Wang Y, Derian CK, Yang J, de Garavilla L, Andrade-Gordon P, Damiano BP | title = Mer receptor tyrosine kinase signaling participates in platelet function | journal = Arteriosclerosis, Thrombosis, and Vascular Biology | volume = 24 | issue = 6 | pages = 1118–23 | date = June 2004 | pmid = 15130911 | doi = 10.1161/01.ATV.0000130662.30537.08 }}
*{{cite journal | author=Thompson DA, McHenry CL, Li Y, ''et al.'' |title=Retinal dystrophy due to paternal isodisomy for chromosome 1 or chromosome 2, with homoallelism for mutations in RPE65 or MERTK, respectively. |journal=Am. J. Hum. Genet. |volume=70 |issue= 1 |pages= 224-9 |year= 2002 |pmid= 11727200 |doi= }}
* {{cite journal | vauthors = Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW | title = Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation | journal = Nature Biotechnology | volume = 22 | issue = 6 | pages = 707–16 | date = June 2004 | pmid = 15146197 | doi = 10.1038/nbt971 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Li Y, Mahajan NP, Webster-Cyriaque J, Bhende P, Hong GK, Earp HS, Kenney S | title = The C-mer gene is induced by Epstein-Barr virus immediate-early protein BRLF1 | journal = Journal of Virology | volume = 78 | issue = 21 | pages = 11778–85 | date = November 2004 | pmid = 15479819 | pmc = 523243 | doi = 10.1128/JVI.78.21.11778-11785.2004 }}
*{{cite journal | author=Yin JL, Hambly BD, Bao SS, ''et al.'' |title=Expression of growth arrest-specific gene 6 and its receptors in dysfunctional human renal allografts. |journal=Transpl. Int. |volume=16 |issue= 9 |pages= 681-8 |year= 2004 |pmid= 12768229 |doi= 10.1007/s00147-003-0593-3 }}
* {{cite journal | vauthors = Gould WR, Baxi SM, Schroeder R, Peng YW, Leadley RJ, Peterson JT, Perrin LA | title = Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses | journal = Journal of Thrombosis and Haemostasis | volume = 3 | issue = 4 | pages = 733–41 | date = April 2005 | pmid = 15733062 | doi = 10.1111/j.1538-7836.2005.01186.x }}
*{{cite journal | author=McHenry CL, Liu Y, Feng W, ''et al.'' |title=MERTK arginine-844-cysteine in a patient with severe rod-cone dystrophy: loss of mutant protein function in transfected cells. |journal=Invest. Ophthalmol. Vis. Sci. |volume=45 |issue= 5 |pages= 1456-63 |year= 2004 |pmid= 15111602 |doi= }}
* {{cite journal | vauthors = Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD | title = Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry | journal = Journal of Proteome Research | volume = 4 | issue = 6 | pages = 2070–80 | year = 2006 | pmid = 16335952 | pmc = 1850943 | doi = 10.1021/pr0502065 }}
*{{cite journal | author=Chen C, Li Q, Darrow AL, ''et al.'' |title=Mer receptor tyrosine kinase signaling participates in platelet function. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=24 |issue= 6 |pages= 1118-23 |year= 2004 |pmid= 15130911 |doi= 10.1161/01.ATV.0000130662.30537.08 }}
* {{cite journal | vauthors = Graham DK, Salzberg DB, Kurtzberg J, Sather S, Matsushima GK, Keating AK, Liang X, Lovell MA, Williams SA, Dawson TL, Schell MJ, Anwar AA, Snodgrass HR, Earp HS | title = Ectopic expression of the proto-oncogene Mer in pediatric T-cell acute lymphoblastic leukemia | journal = Clinical Cancer Research | volume = 12 | issue = 9 | pages = 2662–9 | date = May 2006 | pmid = 16675557 | doi = 10.1158/1078-0432.CCR-05-2208 }}
*{{cite journal | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
* {{cite journal | vauthors = Tada A, Wada Y, Sato H, Itabashi T, Kawamura M, Tamai M, Nishida K | title = Screening of the MERTK gene for mutations in Japanese patients with autosomal recessive retinitis pigmentosa | journal = Molecular Vision | volume = 12 | issue =  | pages = 441–4 | date = May 2006 | pmid = 16710167 | doi =  }}
*{{cite journal | author=Li Y, Mahajan NP, Webster-Cyriaque J, ''et al.'' |title=The C-mer gene is induced by Epstein-Barr virus immediate-early protein BRLF1. |journal=J. Virol. |volume=78 |issue= 21 |pages= 11778-85 |year= 2004 |pmid= 15479819 |doi= 10.1128/JVI.78.21.11778-11785.2004 }}
*{{cite journal | author=Gould WR, Baxi SM, Schroeder R, ''et al.'' |title=Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses. |journal=J. Thromb. Haemost. |volume=3 |issue= 4 |pages= 733-41 |year= 2005 |pmid= 15733062 |doi= 10.1111/j.1538-7836.2005.01186.x }}
*{{cite journal  | author=Liu T, Qian WJ, Gritsenko MA, ''et al.'' |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070-80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 }}
*{{cite journal  | author=Graham DK, Salzberg DB, Kurtzberg J, ''et al.'' |title=Ectopic expression of the proto-oncogene Mer in pediatric T-cell acute lymphoblastic leukemia. |journal=Clin. Cancer Res. |volume=12 |issue= 9 |pages= 2662-9 |year= 2006 |pmid= 16675557 |doi= 10.1158/1078-0432.CCR-05-2208 }}
*{{cite journal  | author=Tada A, Wada Y, Sato H, ''et al.'' |title=Screening of the MERTK gene for mutations in Japanese patients with autosomal recessive retinitis pigmentosa. |journal=Mol. Vis. |volume=12 |issue=  |pages= 441-4 |year= 2006 |pmid= 16710167 |doi=  }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* [https://www.ncbi.nlm.nih.gov/books/NBK1417/  GeneReviews/NCBI/NIH/UW entry on Retinitis Pigmentosa Overview]
 
{{PDB Gallery|geneid=10461}}
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Revision as of 15:48, 30 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Proto-oncogene tyrosine-protein kinase MER is an enzyme that in humans is encoded by the MERTK gene.[1][2][3]

Function

This gene is a member of the TYRO3/AXL/MER (TAM) receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).[3]

References

  1. ↑ Graham DK, Dawson TL, Mullaney DL, Snodgrass HR, Earp HS (June 1994). "Cloning and mRNA expression analysis of a novel human protooncogene, c-mer". Cell Growth & Differentiation. 5 (6): 647–57. PMID 8086340.
  2. ↑ Weier HU, Fung J, Lersch RA (Jun 1999). "Assignment of protooncogene MERTK (a.k.a. c-mer) to human chromosome 2q14.1 by in situ hybridization". Cytogenetics and Cell Genetics. 84 (1–2): 91–2. doi:10.1159/000015223. PMID 10343112.
  3. ↑ 3.0 3.1 "Entrez Gene: MERTK c-mer proto-oncogene tyrosine kinase".

Further reading

External links


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