Nuclear receptor coactivator 3: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
The '''nuclear receptor coactivator 3''' also known as '''NCOA3''' is a [[protein]] that, in humans, is encoded by the ''NCOA3'' [[gene]].<ref name="pmid9252329">{{cite journal | vauthors = Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM, Meltzer PS | title = AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer | journal = Science | volume = 277 | issue = 5328 | pages = 965–8 | date = August 1997 | pmid = 9252329 | doi = 10.1126/science.277.5328.965 | url =  }}</ref><ref name="pmid9346901">{{cite journal | vauthors = Takeshita A, Cardona GR, Koibuchi N, Suen CS, Chin WW | title = TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1 | journal = J. Biol. Chem. | volume = 272 | issue = 44 | pages = 27629–34 | date = October 1997 | pmid = 9346901 | doi = 10.1074/jbc.272.44.27629 | url = }}</ref> NCOA3 is also frequently called 'amplified in breast 1' ('''AIB1'''), steroid receptor coactivator-3 ('''SRC-3'''), or thyroid hormone receptor activator molecule 1 ('''TRAM-1''').
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = no
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_NCOA3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1kbh.
| PDB = {{PDB2|1kbh}}
| Name = Nuclear receptor coactivator 3
| HGNCid = 7670
| Symbol = NCOA3
| AltSymbols =; RAC3; ACTR; AIB-1; AIB1; CAGH16; CTG26; MGC141848; SRC-1; SRC3; TNRC14; TNRC16; TRAM-1; pCIP
| OMIM = 601937
| ECnumber = 
| Homologene = 4764
| MGIid = 1276535
| GeneAtlas_image1 = PBB_GE_NCOA3_207700_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_NCOA3_209060_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_NCOA3_209062_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0004402 |text = histone acetyltransferase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008415 |text = acyltransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0030528 |text = transcription regulator activity}} {{GNF_GO|id=GO:0046966 |text = thyroid hormone receptor binding}} {{GNF_GO|id=GO:0050681 |text = androgen receptor binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0030521 |text = androgen receptor signaling pathway}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8202
    | Hs_Ensembl = ENSG00000124151
    | Hs_RefseqProtein = NP_006525
    | Hs_RefseqmRNA = NM_006534
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 45564053
    | Hs_GenLoc_end = 45717938
    | Hs_Uniprot = Q9Y6Q9
    | Mm_EntrezGene = 17979
    | Mm_Ensembl = ENSMUSG00000027678
    | Mm_RefseqmRNA = NM_008679
    | Mm_RefseqProtein = NP_032705
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 165683882
    | Mm_GenLoc_end = 165762141
    | Mm_Uniprot = O09000
  }}
}}
The '''nuclear receptor coactivator 3''' ({{gene|NCOA3}}) is a transcriptional coregulatory protein which contains several [[nuclear receptor]] interacting domains and an intrinsic [[histone acetyltransferase]] activity.  NCOA3 is recruited to DNA promotion sites by ligand activated nuclear receptors.  NCOA3 in turn acylates histones which makes downsteam DNA more accessible to transcription.  Hence NCOA3 assists nuclear receptors in the upregulation of gene expression.<ref name="Anzick_1997">{{cite journal |author=Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM, Meltzer PS|title=AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer|journal= Science |volume= 277 |issue= 5328 |pages= 965-8 |year= 1997| doi = 10.1126/science.277.5328.965 |pmid= 9252329}}</ref><ref name="Takeshita_1997">{{cite journal |author=Takeshita A, Cardona GR, Koibuchi N, Suen CS, Chin WW|title=TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1|journal=J Biol Chem |volume= 272 |issue= 44 |pages= 27629-34 |year= 1997| doi = 10.1074/jbc.272.44.27629|pmid= 9346901}}</ref>


NCOA3 is also frequently called amplified in breast 1 ('''AIB1'''), steroid receptor coactivator-3 ('''SRC-3'''), or thyroid hormone receptor activator molecule 1 ('''TRAM-1''').
NCOA3 is a transcriptional [[coactivator (genetics)|coactivator]] protein that contains several [[nuclear receptor]] interacting domains and an intrinsic [[histone acetyltransferase]] activity.  NCOA3 is recruited to DNA promotion sites by ligand-activated nuclear receptors.  NCOA3, in turn, acylates [[histone]]s, which makes downstream DNA more accessible to transcription.  Hence, NCOA3 assists [[nuclear receptor]]s in the upregulation of gene expression.<ref name="Anzick_1997">{{cite journal | vauthors = Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM, Meltzer PS | title = AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer | journal = Science | volume = 277 | issue = 5328 | pages = 965–8 | year = 1997 | pmid = 9252329 | doi = 10.1126/science.277.5328.965 }}</ref><ref name="Takeshita_1997">{{cite journal | vauthors = Takeshita A, Cardona GR, Koibuchi N, Suen CS, Chin WW | title = TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1 | journal = J Biol Chem | volume = 272 | issue = 44 | pages = 27629–34 | year = 1997 | pmid = 9346901 | doi = 10.1074/jbc.272.44.27629 }}</ref>


==References==
==Clinical significance==
<div class="references-small">{{reflist|2}}</div>


==Further reading==
The ratio of [[PAX2]] to AIB-1 protein expression may be predictive of the effectiveness of [[tamoxifen]] in [[breast cancer treatment]].<ref name="urlCORDIS : News">{{cite web | url = http://cordis.europa.eu/fetch?CALLER=EN_NEWS&ACTION=D&SESSION=&RCN=30093 | title = Study sheds new light on tamoxifen resistance | authorlink = | date = 2008-11-13 | format = | work = Cordis News | publisher = Cordis | pages = | archiveurl = | archivedate = | quote = | accessdate = 2008-11-14}}</ref><ref name="pmid19005469">{{cite journal | vauthors = Hurtado A, Holmes KA, Geistlinger TR, Hutcheson IR, Nicholson RI, Brown M, Jiang J, Howat WJ, Ali S, Carroll JS | title = Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen | journal = Nature | volume = 456 | issue = 7222 | pages = 663–6 | date = December 2008 | pmid = 19005469 | pmc = 2920208 | doi = 10.1038/nature07483 | url =  }}</ref>
{{refbegin | 2}}
 
{{PBB_Further_reading
== Interactions ==
| citations =  
Nuclear receptor coactivator 3 has been shown to [[Protein-protein interaction|interact]] with:
*{{cite journal  | author=Liao L, Kuang SQ, Yuan Y, ''et al.'' |title=Molecular structure and biological function of the cancer-amplified nuclear receptor coactivator SRC-3/AIB1. |journal=J. Steroid Biochem. Mol. Biol. |volume=83 |issue= 1-5 |pages= 3-14 |year= 2003 |pmid= 12650696 |doi= }}
{{div col|colwidth=20em}}
*{{cite journal | author=Liu F, Ventura F, Doody J, Massagué J |title=Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs. |journal=Mol. Cell. Biol. |volume=15 |issue= 7 |pages= 3479-86 |year= 1995 |pmid= 7791754 |doi=  }}
* [[Androgen receptor]],<ref name = pmid10965917>{{cite journal | vauthors = Tan JA, Hall SH, Petrusz P, French FS | title = Thyroid receptor activator molecule, TRAM-1, is an androgen receptor coactivator | journal = Endocrinology | volume = 141 | issue = 9 | pages = 3440–50 | date = September 2000 | pmid = 10965917 | doi = 10.1210/endo.141.9.7680 }}</ref><ref name = pmid11747336>{{cite journal | vauthors = Gnanapragasam VJ, Leung HY, Pulimood AS, Neal DE, Robson CN | title = Expression of RAC 3, a steroid hormone receptor co-activator in prostate cancer | journal = Br. J. Cancer | volume = 85 | issue = 12 | pages = 1928–36 | date = December 2001 | pmid = 11747336 | pmc = 2364015 | doi = 10.1054/bjoc.2001.2179 }}</ref><ref name = pmid14966121>{{cite journal | vauthors = Wang Q, Udayakumar TS, Vasaitis TS, Brodie AM, Fondell JD | title = Mechanistic relationship between androgen receptor polyglutamine tract truncation and androgen-dependent transcriptional hyperactivity in prostate cancer cells | journal = J. Biol. Chem. | volume = 279 | issue = 17 | pages = 17319–28 | date = April 2004 | pmid = 14966121 | doi = 10.1074/jbc.M400970200 }}</ref>
*{{cite journal  | author=Guan XY, Xu J, Anzick SL, ''et al.'' |title=Hybrid selection of transcribed sequences from microdissected DNA: isolation of genes within amplified region at 20q11-q13.2 in breast cancer. |journal=Cancer Res. |volume=56 |issue= 15 |pages= 3446-50 |year= 1996 |pmid= 8758910 |doi= }}
* [[CHUK]]<ref name = pmid11971985/> and
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* [[CREB-binding protein]],<ref name = pmid11971985/><ref name = pmid11076796>{{cite journal | vauthors = Naltner A, Wert S, Whitsett JA, Yan C | title = Temporal/spatial expression of nuclear receptor coactivators in the mouse lung | journal = Am. J. Physiol. Lung Cell Mol. Physiol. | volume = 279 | issue = 6 | pages = L1066-74 | date = December 2000 | pmid = 11076796 | doi =  }}</ref>
*{{cite journal | author=Margolis RL, Abraham MR, Gatchell SB, ''et al.'' |title=cDNAs with long CAG trinucleotide repeats from human brain. |journal=Hum. Genet. |volume=100 |issue= 1 |pages= 114-22 |year= 1997 |pmid= 9225980 |doi= }}
* [[DDX17]],<ref name = pmid11250900>{{cite journal | vauthors = Watanabe M, Yanagisawa J, Kitagawa H, Takeyama K, Ogawa S, Arao Y, Suzawa M, Kobayashi Y, Yano T, Yoshikawa H, Masuhiro Y, Kato S | title = A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA | journal = EMBO J. | volume = 20 | issue = 6 | pages = 1341–52 | date = March 2001 | pmid = 11250900 | pmc = 145523 | doi = 10.1093/emboj/20.6.1341 }}</ref>
*{{cite journal | author=Li H, Gomes PJ, Chen JD |title=RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 16 |pages= 8479-84 |year= 1997 |pmid= 9238002 |doi=  }}
* [[DDX5]],<ref name = pmid11250900/>
*{{cite journal | author=Anzick SL, Kononen J, Walker RL, ''et al.'' |title=AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. |journal=Science |volume=277 |issue= 5328 |pages= 965-8 |year= 1997 |pmid= 9252329 |doi= }}
* [[Estrogen receptor alpha]],<ref name = pmid11250900/><ref name = pmid11389589>{{cite journal | vauthors = Wong CW, Komm B, Cheskis BJ | title = Structure-function evaluation of ER alpha and beta interplay with SRC family coactivators. ER selective ligands | journal = Biochemistry | volume = 40 | issue = 23 | pages = 6756–65 | date = June 2001 | pmid = 11389589 | doi = 10.1021/bi010379h }}</ref><ref name = pmid11050174>{{cite journal | vauthors = Tikkanen MK, Carter DJ, Harris AM, Le HM, Azorsa DO, Meltzer PS, Murdoch FE | title = Endogenously expressed estrogen receptor and coactivator AIB1 interact in MCF-7 human breast cancer cells | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 23 | pages = 12536–40 | date = November 2000 | pmid = 11050174 | pmc = 18799 | doi = 10.1073/pnas.220427297 }}</ref>
*{{cite journal | author=Chen H, Lin RJ, Schiltz RL, ''et al.'' |title=Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. |journal=Cell |volume=90 |issue= 3 |pages= 569-80 |year= 1997 |pmid= 9267036 |doi= }}
* [[Estrogen receptor beta]],<ref name = pmid11389589/><ref name = pmid10681591>{{cite journal | vauthors = Leo C, Li H, Chen JD | title = Differential mechanisms of nuclear receptor regulation by receptor-associated coactivator 3 | journal = J. Biol. Chem. | volume = 275 | issue = 8 | pages = 5976–82 | date = February 2000 | pmid = 10681591 | doi = 10.1074/jbc.275.8.5976 }}</ref>
*{{cite journal | author=Takeshita A, Cardona GR, Koibuchi N, ''et al.'' |title=TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1. |journal=J. Biol. Chem. |volume=272 |issue= 44 |pages= 27629-34 |year= 1997 |pmid= 9346901 |doi= }}
* [[Glucocorticoid receptor]],<ref name = pmid12917342>{{cite journal | vauthors = Hsiao PW, Fryer CJ, Trotter KW, Wang W, Archer TK | title = BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation | journal = Mol. Cell. Biol. | volume = 23 | issue = 17 | pages = 6210–20 | date = September 2003 | pmid = 12917342 | pmc = 180928 | doi = 10.1128/MCB.23.17.6210-6220.2003 }}</ref><ref name = pmid11266503>{{cite journal | vauthors = Zilliacus J, Holter E, Wakui H, Tazawa H, Treuter E, Gustafsson JA | title = Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140 | journal = Mol. Endocrinol. | volume = 15 | issue = 4 | pages = 501–11 | date = April 2001 | pmid = 11266503 | doi = 10.1210/mend.15.4.0624 }}</ref>
*{{cite journal | author=Korzus E, Torchia J, Rose DW, ''et al.'' |title=Transcription factor-specific requirements for coactivators and their acetyltransferase functions. |journal=Science |volume=279 |issue= 5351 |pages= 703-7 |year= 1998 |pmid= 9445475 |doi= }}
* [[IKBKG]],<ref name = pmid11971985/>
*{{cite journal | author=Shirazi SK, Bober MA, Coetzee GA |title=Polymorphic exonic CAG microsatellites in the gene amplified in breast cancer (AIB1 gene). |journal=Clin. Genet. |volume=54 |issue= 1 |pages= 102-3 |year= 1998 |pmid= 9727751 |doi= }}
* [[IKK2]],<ref name = pmid11971985>{{cite journal | vauthors = Wu RC, Qin J, Hashimoto Y, Wong J, Xu J, Tsai SY, Tsai MJ, O'Malley BW | title = Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase | journal = Mol. Cell. Biol. | volume = 22 | issue = 10 | pages = 3549–61 | date = May 2002 | pmid = 11971985 | pmc = 133790 | doi = 10.1128/MCB.22.10.3549-3561.2002 }}</ref>
*{{cite journal | author=Wang JC, Stafford JM, Granner DK |title=SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4. |journal=J. Biol. Chem. |volume=273 |issue= 47 |pages= 30847-50 |year= 1998 |pmid= 9812974 |doi= }}
* [[Peroxisome proliferator-activated receptor gamma]],<ref name = pmid10944516>{{cite journal | vauthors = Kodera Y, Takeyama K, Murayama A, Suzawa M, Masuhiro Y, Kato S | title = Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators | journal = J. Biol. Chem. | volume = 275 | issue = 43 | pages = 33201–4 | date = October 2000 | pmid = 10944516 | doi = 10.1074/jbc.C000517200 }}</ref>  and
*{{cite journal | author=Zwijsen RM, Buckle RS, Hijmans EM, ''et al.'' |title=Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1. |journal=Genes Dev. |volume=12 |issue= 22 |pages= 3488-98 |year= 1999 |pmid= 9832502 |doi= }}
* [[Retinoid X receptor alpha]].<ref name = pmid9267036>{{cite journal | vauthors = Chen H, Lin RJ, Schiltz RL, Chakravarti D, Nash A, Nagy L, Privalsky ML, Nakatani Y, Evans RM | title = Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300 | journal = Cell | volume = 90 | issue = 3 | pages = 569–80 | date = August 1997 | pmid = 9267036 | doi = 10.1016/S0092-8674(00)80516-4 }}</ref><ref name = pmid11851396>{{cite journal | vauthors = Lee WY, Noy N | title = Interactions of RXR with coactivators are differentially mediated by helix 11 of the receptor's ligand binding domain | journal = Biochemistry | volume = 41 | issue = 8 | pages = 2500–8 | date = February 2002 | pmid = 11851396 | doi = 10.1021/bi011764 }}</ref>
*{{cite journal | author=Chen H, Lin RJ, Xie W, ''et al.'' |title=Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase. |journal=Cell |volume=98 |issue= 5 |pages= 675-86 |year= 1999 |pmid= 10490106 |doi= }}
{{Div col end}}
*{{cite journal | author=Ebisawa T, Tada K, Kitajima I, ''et al.'' |title=Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation. |journal=J. Cell. Sci. |volume=112 ( Pt 20) |issue= |pages= 3519-27 |year= 2000 |pmid= 10504300 |doi= }}
 
*{{cite journal | author=Xie W, Hong H, Yang NN, ''et al.'' |title=Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2. |journal=Mol. Endocrinol. |volume=13 |issue= 12 |pages= 2151-62 |year= 2000 |pmid= 10598588 |doi= }}
== References ==
*{{cite journal  | author=Pao GM, Janknecht R, Ruffner H, ''et al.'' |title=CBP/p300 interact with and function as transcriptional coactivators of BRCA1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 3 |pages= 1020-5 |year= 2000 |pmid= 10655477 |doi=  }}
{{reflist|30em}}
*{{cite journal  | author=Leo C, Li H, Chen JD |title=Differential mechanisms of nuclear receptor regulation by receptor-associated coactivator 3. |journal=J. Biol. Chem. |volume=275 |issue= 8 |pages= 5976-82 |year= 2000 |pmid= 10681591 |doi= }}
 
*{{cite journal | author=Font de Mora J, Brown M |title=AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor. |journal=Mol. Cell. Biol. |volume=20 |issue= 14 |pages= 5041-7 |year= 2000 |pmid= 10866661 |doi=  }}
== External links ==
*{{cite journal  | author=Tan JA, Hall SH, Petrusz P, French FS |title=Thyroid receptor activator molecule, TRAM-1, is an androgen receptor coactivator. |journal=Endocrinology |volume=141 |issue= 9 |pages= 3440-50 |year= 2000 |pmid= 10965917 |doi= }}
* {{MeshName|nuclear+receptor+coactivator+3|3=nuclear receptor coactivator 3}}
}}
* {{NURSA|C91}}
 
== Further reading ==
{{refbegin|35em}}
* {{cite journal | vauthors = Liao L, Kuang SQ, Yuan Y, Gonzalez SM, O'Malley BW, Xu J | title = Molecular structure and biological function of the cancer-amplified nuclear receptor coactivator SRC-3/AIB1 | journal = J. Steroid Biochem. Mol. Biol. | volume = 83 | issue = 1–5 | pages = 3–14 | year = 2003 | pmid = 12650696 | doi = 10.1016/S0960-0760(02)00254-6 }}
* {{cite journal | vauthors = Liu F, Ventura F, Doody J, Massagué J | title = Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs | journal = Mol. Cell. Biol. | volume = 15 | issue = 7 | pages = 3479–86 | year = 1995 | pmid = 7791754 | pmc = 230584 | doi =  10.1128/mcb.15.7.3479}}
* {{cite journal | vauthors = Guan XY, Xu J, Anzick SL, Zhang H, Trent JM, Meltzer PS | title = Hybrid selection of transcribed sequences from microdissected DNA: isolation of genes within amplified region at 20q11-q13.2 in breast cancer | journal = Cancer Res. | volume = 56 | issue = 15 | pages = 3446–50 | year = 1996 | pmid = 8758910 | doi =  }}
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1997 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
* {{cite journal | vauthors = Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA | title = cDNAs with long CAG trinucleotide repeats from human brain | journal = Hum. Genet. | volume = 100 | issue = 1 | pages = 114–22 | year = 1997 | pmid = 9225980 | doi = 10.1007/s004390050476 }}
* {{cite journal | vauthors = Li H, Gomes PJ, Chen JD | title = RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 16 | pages = 8479–84 | year = 1997 | pmid = 9238002 | pmc = 22964 | doi = 10.1073/pnas.94.16.8479 }}
* {{cite journal | vauthors = Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM, Meltzer PS | title = AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer | journal = Science | volume = 277 | issue = 5328 | pages = 965–8 | year = 1997 | pmid = 9252329 | doi = 10.1126/science.277.5328.965 }}
* {{cite journal | vauthors = Chen H, Lin RJ, Schiltz RL, Chakravarti D, Nash A, Nagy L, Privalsky ML, Nakatani Y, Evans RM | title = Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300 | journal = Cell | volume = 90 | issue = 3 | pages = 569–80 | year = 1997 | pmid = 9267036 | doi = 10.1016/S0092-8674(00)80516-4 }}
* {{cite journal | vauthors = Takeshita A, Cardona GR, Koibuchi N, Suen CS, Chin WW | title = TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1 | journal = J. Biol. Chem. | volume = 272 | issue = 44 | pages = 27629–34 | year = 1997 | pmid = 9346901 | doi = 10.1074/jbc.272.44.27629 }}
* {{cite journal | vauthors = Korzus E, Torchia J, Rose DW, Xu L, Kurokawa R, McInerney EM, Mullen TM, Glass CK, Rosenfeld MG | title = Transcription factor-specific requirements for coactivators and their acetyltransferase functions | journal = Science | volume = 279 | issue = 5351 | pages = 703–7 | year = 1998 | pmid = 9445475 | doi = 10.1126/science.279.5351.703 }}
* {{cite journal | vauthors = Shirazi SK, Bober MA, Coetzee GA | title = Polymorphic exonic CAG microsatellites in the gene amplified in breast cancer (AIB1 gene) | journal = Clin. Genet. | volume = 54 | issue = 1 | pages = 102–3 | year = 1998 | pmid = 9727751 | doi = 10.1111/j.1399-0004.1998.tb03704.x }}
* {{cite journal | vauthors = Wang JC, Stafford JM, Granner DK | title = SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4 | journal = J. Biol. Chem. | volume = 273 | issue = 47 | pages = 30847–50 | year = 1998 | pmid = 9812974 | doi = 10.1074/jbc.273.47.30847 }}
* {{cite journal | vauthors = Zwijsen RM, Buckle RS, Hijmans EM, Loomans CJ, Bernards R | title = Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1 | journal = Genes Dev. | volume = 12 | issue = 22 | pages = 3488–98 | year = 1999 | pmid = 9832502 | pmc = 317237 | doi = 10.1101/gad.12.22.3488 }}
* {{cite journal | vauthors = Chen H, Lin RJ, Xie W, Wilpitz D, Evans RM | title = Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase | journal = Cell | volume = 98 | issue = 5 | pages = 675–86 | year = 1999 | pmid = 10490106 | doi = 10.1016/S0092-8674(00)80054-9 }}
* {{cite journal | vauthors = Ebisawa T, Tada K, Kitajima I, Tojo K, Sampath TK, Kawabata M, Miyazono K, Imamura T | title = Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation | journal = J. Cell Sci. | volume = 112 | issue = 20 | pages = 3519–27 | year = 2000 | pmid = 10504300 | doi =  }}
* {{cite journal | vauthors = Xie W, Hong H, Yang NN, Lin RJ, Simon CM, Stallcup MR, Evans RM | title = Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2 | journal = Mol. Endocrinol. | volume = 13 | issue = 12 | pages = 2151–62 | year = 2000 | pmid = 10598588 | doi = 10.1210/me.13.12.2151 }}
* {{cite journal | vauthors = Pao GM, Janknecht R, Ruffner H, Hunter T, Verma IM | title = CBP/p300 interact with and function as transcriptional coactivators of BRCA1 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 3 | pages = 1020–5 | year = 2000 | pmid = 10655477 | pmc = 15508 | doi = 10.1073/pnas.97.3.1020 }}
* {{cite journal | vauthors = Leo C, Li H, Chen JD | title = Differential mechanisms of nuclear receptor regulation by receptor-associated coactivator 3 | journal = J. Biol. Chem. | volume = 275 | issue = 8 | pages = 5976–82 | year = 2000 | pmid = 10681591 | doi = 10.1074/jbc.275.8.5976 }}
* {{cite journal | vauthors = Font de Mora J, Brown M | title = AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor | journal = Mol. Cell. Biol. | volume = 20 | issue = 14 | pages = 5041–7 | year = 2000 | pmid = 10866661 | pmc = 85954 | doi = 10.1128/MCB.20.14.5041-5047.2000 }}
* {{cite journal | vauthors = Tan JA, Hall SH, Petrusz P, French FS | title = Thyroid receptor activator molecule, TRAM-1, is an androgen receptor coactivator | journal = Endocrinology | volume = 141 | issue = 9 | pages = 3440–50 | year = 2000 | pmid = 10965917 | doi = 10.1210/endo.141.9.7680 }}
{{refend}}
{{refend}}


 
{{PDB Gallery|geneid=8202}}
==External links==
* {{MeshName|nuclear+receptor+coactivator+3}}


{{Transcription coregulators}}
{{Transcription coregulators}}


[[Category:Transcription coregulators]]
[[Category:Transcription coregulators]]
 
[[Category:PAS-domain-containing proteins]]
[[fr:Nuclear receptor coactivator 3]]

Revision as of 20:29, 8 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

The nuclear receptor coactivator 3 also known as NCOA3 is a protein that, in humans, is encoded by the NCOA3 gene.[1][2] NCOA3 is also frequently called 'amplified in breast 1' (AIB1), steroid receptor coactivator-3 (SRC-3), or thyroid hormone receptor activator molecule 1 (TRAM-1).

Function

NCOA3 is a transcriptional coactivator protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA3 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA3, in turn, acylates histones, which makes downstream DNA more accessible to transcription. Hence, NCOA3 assists nuclear receptors in the upregulation of gene expression.[3][4]

Clinical significance

The ratio of PAX2 to AIB-1 protein expression may be predictive of the effectiveness of tamoxifen in breast cancer treatment.[5][6]

Interactions

Nuclear receptor coactivator 3 has been shown to interact with:

References

  1. ↑ Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM, Meltzer PS (August 1997). "AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer". Science. 277 (5328): 965–8. doi:10.1126/science.277.5328.965. PMID 9252329.
  2. ↑ Takeshita A, Cardona GR, Koibuchi N, Suen CS, Chin WW (October 1997). "TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1". J. Biol. Chem. 272 (44): 27629–34. doi:10.1074/jbc.272.44.27629. PMID 9346901.
  3. ↑ Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM, Meltzer PS (1997). "AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer". Science. 277 (5328): 965–8. doi:10.1126/science.277.5328.965. PMID 9252329.
  4. ↑ Takeshita A, Cardona GR, Koibuchi N, Suen CS, Chin WW (1997). "TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1". J Biol Chem. 272 (44): 27629–34. doi:10.1074/jbc.272.44.27629. PMID 9346901.
  5. ↑ "Study sheds new light on tamoxifen resistance". Cordis News. Cordis. 2008-11-13. Retrieved 2008-11-14.
  6. ↑ Hurtado A, Holmes KA, Geistlinger TR, Hutcheson IR, Nicholson RI, Brown M, Jiang J, Howat WJ, Ali S, Carroll JS (December 2008). "Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen". Nature. 456 (7222): 663–6. doi:10.1038/nature07483. PMC 2920208. PMID 19005469.
  7. ↑ Tan JA, Hall SH, Petrusz P, French FS (September 2000). "Thyroid receptor activator molecule, TRAM-1, is an androgen receptor coactivator". Endocrinology. 141 (9): 3440–50. doi:10.1210/endo.141.9.7680. PMID 10965917.
  8. ↑ Gnanapragasam VJ, Leung HY, Pulimood AS, Neal DE, Robson CN (December 2001). "Expression of RAC 3, a steroid hormone receptor co-activator in prostate cancer". Br. J. Cancer. 85 (12): 1928–36. doi:10.1054/bjoc.2001.2179. PMC 2364015. PMID 11747336.
  9. ↑ Wang Q, Udayakumar TS, Vasaitis TS, Brodie AM, Fondell JD (April 2004). "Mechanistic relationship between androgen receptor polyglutamine tract truncation and androgen-dependent transcriptional hyperactivity in prostate cancer cells". J. Biol. Chem. 279 (17): 17319–28. doi:10.1074/jbc.M400970200. PMID 14966121.
  10. ↑ 10.0 10.1 10.2 10.3 Wu RC, Qin J, Hashimoto Y, Wong J, Xu J, Tsai SY, Tsai MJ, O'Malley BW (May 2002). "Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase". Mol. Cell. Biol. 22 (10): 3549–61. doi:10.1128/MCB.22.10.3549-3561.2002. PMC 133790. PMID 11971985.
  11. ↑ Naltner A, Wert S, Whitsett JA, Yan C (December 2000). "Temporal/spatial expression of nuclear receptor coactivators in the mouse lung". Am. J. Physiol. Lung Cell Mol. Physiol. 279 (6): L1066–74. PMID 11076796.
  12. ↑ 12.0 12.1 12.2 Watanabe M, Yanagisawa J, Kitagawa H, Takeyama K, Ogawa S, Arao Y, Suzawa M, Kobayashi Y, Yano T, Yoshikawa H, Masuhiro Y, Kato S (March 2001). "A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA". EMBO J. 20 (6): 1341–52. doi:10.1093/emboj/20.6.1341. PMC 145523. PMID 11250900.
  13. ↑ 13.0 13.1 Wong CW, Komm B, Cheskis BJ (June 2001). "Structure-function evaluation of ER alpha and beta interplay with SRC family coactivators. ER selective ligands". Biochemistry. 40 (23): 6756–65. doi:10.1021/bi010379h. PMID 11389589.
  14. ↑ Tikkanen MK, Carter DJ, Harris AM, Le HM, Azorsa DO, Meltzer PS, Murdoch FE (November 2000). "Endogenously expressed estrogen receptor and coactivator AIB1 interact in MCF-7 human breast cancer cells". Proc. Natl. Acad. Sci. U.S.A. 97 (23): 12536–40. doi:10.1073/pnas.220427297. PMC 18799. PMID 11050174.
  15. ↑ Leo C, Li H, Chen JD (February 2000). "Differential mechanisms of nuclear receptor regulation by receptor-associated coactivator 3". J. Biol. Chem. 275 (8): 5976–82. doi:10.1074/jbc.275.8.5976. PMID 10681591.
  16. ↑ Hsiao PW, Fryer CJ, Trotter KW, Wang W, Archer TK (September 2003). "BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation". Mol. Cell. Biol. 23 (17): 6210–20. doi:10.1128/MCB.23.17.6210-6220.2003. PMC 180928. PMID 12917342.
  17. ↑ Zilliacus J, Holter E, Wakui H, Tazawa H, Treuter E, Gustafsson JA (April 2001). "Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140". Mol. Endocrinol. 15 (4): 501–11. doi:10.1210/mend.15.4.0624. PMID 11266503.
  18. ↑ Kodera Y, Takeyama K, Murayama A, Suzawa M, Masuhiro Y, Kato S (October 2000). "Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators". J. Biol. Chem. 275 (43): 33201–4. doi:10.1074/jbc.C000517200. PMID 10944516.
  19. ↑ Chen H, Lin RJ, Schiltz RL, Chakravarti D, Nash A, Nagy L, Privalsky ML, Nakatani Y, Evans RM (August 1997). "Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300". Cell. 90 (3): 569–80. doi:10.1016/S0092-8674(00)80516-4. PMID 9267036.
  20. ↑ Lee WY, Noy N (February 2002). "Interactions of RXR with coactivators are differentially mediated by helix 11 of the receptor's ligand binding domain". Biochemistry. 41 (8): 2500–8. doi:10.1021/bi011764. PMID 11851396.

External links

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=Nuclear_receptor_coactivator_3&oldid=1419456"