PAPOLA: Difference between revisions

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Poly(A) polymerase alpha is an enzyme that in humans is encoded by the PAPOLA gene.^[1]^[2]^[3]

PAPOLA binds to FIP1L1 (Factor interacting with PAPOLA and CPSF1), a subunit of the cleavage and polyadenylation specificity factor subunit 1 (CPSF1) complex. This complex polyadenylates the 3' end of precursor mRNAs (pre-mRNA) (see CPSF). CPSF1 is an RNA processing protein that binds to uracil-rich sequences in pre-mRNA, binds with and stimulates POPOLA's Polynucleotide adenylyltransferase activity, and thereby adds adenylyl residues to pre-mRNA. This poly-adenylyl action increases pre mRNA's maturation and movement from the nucleus to cytoplasm while dramatically increasing the stability of the mRNA formed from pre-mRNA: FIP1L1 is a Pre-mRNA 3'-end-processing factor. FIP1L1 gene fusions between it and either the platelet-derived growth factor receptor, alpha (PGDFRA) or Retinoic acid receptor alpha (RARA) genes are causes of certain human diseases associated with pathologically increased levels of blood eosinophils and/or Leukemias.^[4]^[5]

References

↑ Thuresson AC, Astrom J, Astrom A, Gronvik KO, Virtanen A (Mar 1994). "Multiple forms of poly(A) polymerases in human cells". Proc Natl Acad Sci U S A. 91 (3): 979–83. doi:10.1073/pnas.91.3.979. PMC 521437. PMID 8302877.
↑ Yamauchi T, Sugimoto J, Hatakeyama T, Asakawa S, Shimizu N, Isobe M (Sep 1999). "Assignment of the human poly(A) polymerase (PAP) gene to chromosome 14q32.1-q32.2 and isolation of a polymorphic CA repeat sequence". J Hum Genet. 44 (4): 253–5. doi:10.1007/s100380050154. PMID 10429366.
↑ "Entrez Gene: PAPOLA poly(A) polymerase alpha".
↑ https://www.ncbi.nlm.nih.gov/gene/81608
↑ https://www.ncbi.nlm.nih.gov/gene/81608

Weichs an der Glon C, Ashe M, Eggermont J, Proudfoot NJ (1993). "Tat-dependent occlusion of the HIV poly(A) site". EMBO J. 12 (5): 2119–28. PMC 413433. PMID 8491200.
Pendurthi UR, Alok D, Rao LV (1997). "Binding of factor VIIa to tissue factor induces alterations in gene expression in human fibroblast cells: up-regulation of poly(A) polymerase". Proc. Natl. Acad. Sci. U.S.A. 94 (23): 12598–603. doi:10.1073/pnas.94.23.12598. PMC 25051. PMID 9356495.
Varani L, Gunderson SI, Mattaj IW, et al. (2000). "The NMR structure of the 38 kDa U1A protein - PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein". Nat. Struct. Biol. 7 (4): 329–35. doi:10.1038/74101. PMID 10742179.
Mouland AJ, Coady M, Yao XJ, Cohen EA (2002). "Hypophosphorylation of poly(A) polymerase and increased polyadenylation activity are associated with human immunodeficiency virus type 1 Vpr expression". Virology. 292 (2): 321–30. doi:10.1006/viro.2001.1261. PMID 11878934.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kim H, Lee JH, Lee Y (2003). "Regulation of poly(A) polymerase by 14-3-3epsilon". EMBO J. 22 (19): 5208–19. doi:10.1093/emboj/cdg486. PMC 204469. PMID 14517258.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
Kaufmann I, Martin G, Friedlein A, et al. (2005). "Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase". EMBO J. 23 (3): 616–26. doi:10.1038/sj.emboj.7600070. PMC 1271804. PMID 14749727.
Dettwiler S, Aringhieri C, Cardinale S, et al. (2005). "Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization". J. Biol. Chem. 279 (34): 35788–97. doi:10.1074/jbc.M403927200. PMID 15169763.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

[pmid8302877-1] Thuresson AC, Astrom J, Astrom A, Gronvik KO, Virtanen A (Mar 1994). "Multiple forms of poly(A) polymerases in human cells". Proc Natl Acad Sci U S A. 91 (3): 979–83. doi:10.1073/pnas.91.3.979. PMC 521437. PMID 8302877.

[pmid10429366-2] Yamauchi T, Sugimoto J, Hatakeyama T, Asakawa S, Shimizu N, Isobe M (Sep 1999). "Assignment of the human poly(A) polymerase (PAP) gene to chromosome 14q32.1-q32.2 and isolation of a polymorphic CA repeat sequence". J Hum Genet. 44 (4): 253–5. doi:10.1007/s100380050154. PMID 10429366.

[entrez-3] "Entrez Gene: PAPOLA poly(A) polymerase alpha".

[4] ttps://www.ncbi.nlm.nih.gov/gene/81608

[5] ttps://www.ncbi.nlm.nih.gov/gene/81608

[1]

[2]

[3]

[4]

[5]

@@ Line 1: / Line 1: @@
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+{{Underlinked|date=March 2014}}
-{{PBB_Controls
+{{Infobox_gene}}
-| update_page = yes
+'''Poly(A) polymerase alpha''' is an [[enzyme]] that in humans is encoded by the ''PAPOLA'' [[gene]].<ref name="pmid8302877">{{cite journal | vauthors = Thuresson AC, Astrom J, Astrom A, Gronvik KO, Virtanen A | title = Multiple forms of poly(A) polymerases in human cells | journal = Proc Natl Acad Sci U S A | volume = 91 | issue = 3 | pages = 979–83 |date=Mar 1994 | pmid = 8302877 | pmc = 521437 | doi =10.1073/pnas.91.3.979  }}</ref><ref name="pmid10429366">{{cite journal | vauthors = Yamauchi T, Sugimoto J, Hatakeyama T, Asakawa S, Shimizu N, Isobe M | title = Assignment of the human poly(A) polymerase (PAP) gene to chromosome 14q32.1-q32.2 and isolation of a polymorphic CA repeat sequence | journal = J Hum Genet | volume = 44 | issue = 4 | pages = 253–5 |date=Sep 1999 | pmid = 10429366 | pmc =  | doi = 10.1007/s100380050154 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PAPOLA poly(A) polymerase alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10914| accessdate = }}</ref>
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+PAPOLA binds to [[FIP1L1]] (Factor interacting with PAPOLA and CPSF1), a subunit of the [[CPSF1|cleavage and polyadenylation specificity factor subunit 1]] (CPSF1) complex. This complex polyadenylates the [[Directionality (molecular biology)|3' end]] of [[precursor mRNA]]s (pre-mRNA) (see [[CPSF]]). CPSF1 is an [[RNA]] processing protein that binds to [[uracil]]-rich sequences in pre-mRNA, binds with and stimulates POPOLA's [[Polynucleotide adenylyltransferase]] activity, and thereby adds [[Adenosine monophosphate|adenylyl]] residues to pre-mRNA. This poly-adenylyl action increases pre mRNA's maturation and movement from the nucleus to cytoplasm while dramatically increasing the stability of the mRNA formed from pre-mRNA: FIP1L1 is a Pre-mRNA 3'-end-processing factor. ''FIP1L1'' [[Fusion gene|gene fusions]] between it and either the [[PDGFRA|platelet-derived growth factor receptor, alpha (''PGDFRA'')]] or [[Retinoic acid receptor alpha]] (RARA) genes are causes of certain human [[Hypereosinophilia|diseases associated with pathologically increased levels of blood eosinophils]] and/or [[Leukemia]]s.<ref>https://www.ncbi.nlm.nih.gov/gene/81608</ref><ref>https://www.ncbi.nlm.nih.gov/gene/81608</ref>
-{{GNF_Protein_box
- | image = PBB_Protein_PAPOLA_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1f5a.
- | PDB = {{PDB2|1f5a}}, {{PDB2|1q78}}, {{PDB2|1q79}}
- | Name = Poly(A) polymerase alpha
- | HGNCid = 14981
- | Symbol = PAPOLA
- | AltSymbols =; PAP; MGC5378
- | OMIM = 605553
- | ECnumber =
- | Homologene = 23389
- | MGIid = 109301
- | GeneAtlas_image1 = PBB_GE_PAPOLA_212718_at_tn.png
- | GeneAtlas_image2 = PBB_GE_PAPOLA_212720_at_tn.png
- | GeneAtlas_image3 = PBB_GE_PAPOLA_222035_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0004652 |text = polynucleotide adenylyltransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
- | Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006378 |text = mRNA polyadenylation}} {{GNF_GO|id=GO:0006397 |text = mRNA processing}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 10914
-    | Hs_Ensembl = ENSG00000090060
-    | Hs_RefseqProtein = NP_116021
-    | Hs_RefseqmRNA = NM_032632
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 14
-    | Hs_GenLoc_start = 96038471
-    | Hs_GenLoc_end = 96103178
-    | Hs_Uniprot = P51003
-    | Mm_EntrezGene = 18789
-    | Mm_Ensembl = ENSMUSG00000021111
-    | Mm_RefseqmRNA = NM_011112
-    | Mm_RefseqProtein = NP_035242
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 12
-    | Mm_GenLoc_start = 106181750
-    | Mm_GenLoc_end = 106239989
-    | Mm_Uniprot = Q3V141
-  }}
-}}
-'''Poly(A) polymerase alpha''', also known as '''PAPOLA''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PAPOLA poly(A) polymerase alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10914| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
@@ Line 57: / Line 12: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Thuresson AC, Aström J, Aström A, ''et al.'' |title=Multiple forms of poly(A) polymerases in human cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 3 |pages= 979-83 |year= 1994 |pmid= 8302877 |doi=  }}
+*{{cite journal  | vauthors=Weichs an der Glon C, Ashe M, Eggermont J, Proudfoot NJ |title=Tat-dependent occlusion of the HIV poly(A) site. |journal=EMBO J. |volume=12 |issue= 5 |pages= 2119–28 |year= 1993 |pmid= 8491200 |doi=  | pmc=413433  }}
-*{{cite journal  | author=Weichs an der Glon C, Ashe M, Eggermont J, Proudfoot NJ |title=Tat-dependent occlusion of the HIV poly(A) site. |journal=EMBO J. |volume=12 |issue= 5 |pages= 2119-28 |year= 1993 |pmid= 8491200 |doi=  }}
+*{{cite journal  | vauthors=Pendurthi UR, Alok D, Rao LV |title=Binding of factor VIIa to tissue factor induces alterations in gene expression in human fibroblast cells: up-regulation of poly(A) polymerase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 23 |pages= 12598–603 |year= 1997 |pmid= 9356495 |doi=10.1073/pnas.94.23.12598  | pmc=25051  }}
-*{{cite journal  | author=Pendurthi UR, Alok D, Rao LV |title=Binding of factor VIIa to tissue factor induces alterations in gene expression in human fibroblast cells: up-regulation of poly(A) polymerase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 23 |pages= 12598-603 |year= 1997 |pmid= 9356495 |doi=  }}
+*{{cite journal   |vauthors=Varani L, Gunderson SI, Mattaj IW, etal |title=The NMR structure of the 38 kDa U1A protein - PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein. |journal=Nat. Struct. Biol. |volume=7 |issue= 4 |pages= 329–35 |year= 2000 |pmid= 10742179 |doi= 10.1038/74101 }}
-*{{cite journal  | author=Yamauchi T, Sugimoto J, Hatakeyama T, ''et al.'' |title=Assignment of the human poly(A) polymerase (PAP) gene to chromosome 14q32.1-q32.2 and isolation of a polymorphic CA repeat sequence. |journal=J. Hum. Genet. |volume=44 |issue= 4 |pages= 253-5 |year= 1999 |pmid= 10429366 |doi=  }}
+*{{cite journal  | vauthors=Mouland AJ, Coady M, Yao XJ, Cohen EA |title=Hypophosphorylation of poly(A) polymerase and increased polyadenylation activity are associated with human immunodeficiency virus type 1 Vpr expression. |journal=Virology |volume=292 |issue= 2 |pages= 321–30 |year= 2002 |pmid= 11878934 |doi= 10.1006/viro.2001.1261 }}
-*{{cite journal  | author=Varani L, Gunderson SI, Mattaj IW, ''et al.'' |title=The NMR structure of the 38 kDa U1A protein - PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein. |journal=Nat. Struct. Biol. |volume=7 |issue= 4 |pages= 329-35 |year= 2000 |pmid= 10742179 |doi= 10.1038/74101 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Mouland AJ, Coady M, Yao XJ, Cohen EA |title=Hypophosphorylation of poly(A) polymerase and increased polyadenylation activity are associated with human immunodeficiency virus type 1 Vpr expression. |journal=Virology |volume=292 |issue= 2 |pages= 321-30 |year= 2002 |pmid= 11878934 |doi= 10.1006/viro.2001.1261 }}
+*{{cite journal  | vauthors=Kim H, Lee JH, Lee Y |title=Regulation of poly(A) polymerase by 14-3-3epsilon. |journal=EMBO J. |volume=22 |issue= 19 |pages= 5208–19 |year= 2003 |pmid= 14517258 |doi= 10.1093/emboj/cdg486  | pmc=204469 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Kim H, Lee JH, Lee Y |title=Regulation of poly(A) polymerase by 14-3-3epsilon. |journal=EMBO J. |volume=22 |issue= 19 |pages= 5208-19 |year= 2003 |pmid= 14517258 |doi= 10.1093/emboj/cdg486 }}
+*{{cite journal   |vauthors=Bouwmeester T, Bauch A, Ruffner H, etal |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal   |vauthors=Kaufmann I, Martin G, Friedlein A, etal |title=Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase. |journal=EMBO J. |volume=23 |issue= 3 |pages= 616–26 |year= 2005 |pmid= 14749727 |doi= 10.1038/sj.emboj.7600070  | pmc=1271804 }}
-*{{cite journal  | author=Bouwmeester T, Bauch A, Ruffner H, ''et al.'' |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97-105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
+*{{cite journal   |vauthors=Dettwiler S, Aringhieri C, Cardinale S, etal |title=Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization. |journal=J. Biol. Chem. |volume=279 |issue= 34 |pages= 35788–97 |year= 2005 |pmid= 15169763 |doi= 10.1074/jbc.M403927200 }}
-*{{cite journal  | author=Kaufmann I, Martin G, Friedlein A, ''et al.'' |title=Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase. |journal=EMBO J. |volume=23 |issue= 3 |pages= 616-26 |year= 2005 |pmid= 14749727 |doi= 10.1038/sj.emboj.7600070 }}
+*{{cite journal   |vauthors=Colland F, Jacq X, Trouplin V, etal |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104  | pmc=442148 }}
-*{{cite journal  | author=Dettwiler S, Aringhieri C, Cardinale S, ''et al.'' |title=Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization. |journal=J. Biol. Chem. |volume=279 |issue= 34 |pages= 35788-97 |year= 2005 |pmid= 15169763 |doi= 10.1074/jbc.M403927200 }}
+*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101  | pmc=514446 }}
-*{{cite journal  | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
+*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
-*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
 }}
 {{refend}}
+{{PDB Gallery|geneid=10914}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
-{{protein-stub}}
+{{gene-14-stub}}
-{{WikiDoc Sources}}

PAPOLA: Difference between revisions

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