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{{ | '''Serpin B6''' is a [[protein]] that in humans is encoded by the ''SERPINB6'' [[gene]].<ref name="pmid8415716">{{cite journal |vauthors=Coughlin P, Sun J, Cerruti L, Salem HH, Bird P | title = Cloning and molecular characterization of a human intracellular serine proteinase inhibitor | journal = Proc Natl Acad Sci U S A | volume = 90 | issue = 20 | pages = 9417–21 |date=Nov 1993 | pmid = 8415716 | pmc = 47579 | doi =10.1073/pnas.90.20.9417 }}</ref><ref name="pmid9858835">{{cite journal |vauthors=Sun J, Stephens R, Mirza G, Kanai H, Ragoussis J, Bird PI | title = A serpin gene cluster on human chromosome 6p25 contains PI6, PI9 and ELANH2 which have a common structure almost identical to the 18q21 ovalbumin serpin genes | journal = Cytogenet Cell Genet | volume = 82 | issue = 3–4 | pages = 273–7 |date=Feb 1999 | pmid = 9858835 | pmc = | doi =10.1159/000015118 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5269| accessdate = }}</ref> | ||
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==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
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| citations = | | citations = | ||
*{{cite journal | | *{{cite journal |vauthors=Sun J, Coughlin P, Salem HH, Bird P |title=Production and characterization of recombinant human proteinase inhibitor 6 expressed in Pichia pastoris |journal=Biochim. Biophys. Acta |volume=1252 |issue= 1 |pages= 28–34 |year= 1995 |pmid= 7548163 |doi=10.1016/0167-4838(95)00108-7 }} | ||
*{{cite journal | author=Coughlin P | *{{cite journal | author=Coughlin P |title=Chromosomal mapping of the human proteinase inhibitor 6 (PI6) gene to 6p25 by fluorescence in situ hybridization |journal=Genomics |volume=26 |issue= 2 |pages= 431–3 |year= 1995 |pmid= 7601482 |doi=10.1016/0888-7543(95)80240-M |name-list-format=vanc| author2=Nicholl J | author3=Sun J | display-authors=3 | last4=Salem | first4=Hatem | last5=Bird | first5=Phillip | last6=Sutherland | first6=Grant R. }} | ||
*{{cite journal | author=Morgenstern KA |title=Complementary DNA cloning and kinetic characterization of a novel intracellular serine proteinase inhibitor: mechanism of action with trypsin and [[factor Xa]] as model proteinases |journal=Biochemistry |volume=33 |issue= 11 |pages= 3432–41 |year= 1994 |pmid= 8136380 |doi=10.1021/bi00177a037 |name-list-format=vanc| author2=Sprecher C | author3=Holth L | display-authors=3 | last4=Foster | first4=Donald | last5=Grant | first5=Francis J. | last6=Ching | first6=Andrew | last7=Kisiel | first7=Walter }} | |||
*{{cite journal | author=Morgenstern KA | *{{cite journal | author=Morgenstern KA |title=Isolation and characterization of an intracellular serine proteinase inhibitor from a monkey kidney epithelial cell line |journal=J. Biol. Chem. |volume=268 |issue= 29 |pages= 21560–8 |year= 1993 |pmid= 8408007 |doi= |name-list-format=vanc| author2=Henzel WJ | author3=Baker JB | display-authors=3 | last4=Wong | first4=S | last5=Pastuszyn | first5=A | last6=Kisiel | first6=W }} | ||
*{{cite journal |vauthors=Coughlin PB, Tetaz T, Salem HH |title=Identification and purification of a novel serine proteinase inhibitor |journal=J. Biol. Chem. |volume=268 |issue= 13 |pages= 9541–7 |year= 1993 |pmid= 8486644 |doi= }} | |||
*{{cite journal | author= | *{{cite journal |vauthors=Riewald M, Morgenstern KA, Schleef RR |title=Identification and characterization of the cytoplasmic antiproteinase (CAP) in human platelets. Evidence for the interaction of CAP with endogenous platelet proteins |journal=J. Biol. Chem. |volume=271 |issue= 12 |pages= 7160–7 |year= 1996 |pmid= 8636153 |doi= 10.1074/jbc.271.12.7160}} | ||
*{{cite journal |vauthors=Riewald M, Schleef RR |title=Human cytoplasmic antiproteinase neutralizes rapidly and efficiently chymotrypsin and trypsin-like proteases utilizing distinct reactive site residues |journal=J. Biol. Chem. |volume=271 |issue= 24 |pages= 14526–32 |year= 1996 |pmid= 8662739 |doi=10.1074/jbc.271.24.14526 }} | |||
*{{cite journal | | *{{cite journal | author=Scott FL |title=Proteinase inhibitor 6 (PI-6) expression in human skin: induction of PI-6 and a PI-6/proteinase complex during keratinocyte differentiation |journal=Exp. Cell Res. |volume=245 |issue= 2 |pages= 263–71 |year= 1999 |pmid= 9851866 |doi= 10.1006/excr.1998.4241 |name-list-format=vanc| author2=Paddle-Ledinek JE | author3=Cerruti L | display-authors=3 | last4=Coughlin | first4=PB | last5=Salem | first5=HH | last6=Bird | first6=PI }} | ||
*{{cite journal | | *{{cite journal | author=Mikolajczyk SD |title=Identification of a novel complex between human kallikrein 2 and protease inhibitor-6 in prostate cancer tissue |journal=Cancer Res. |volume=59 |issue= 16 |pages= 3927–30 |year= 1999 |pmid= 10463585 |doi= |name-list-format=vanc| author2=Millar LS | author3=Marker KM | display-authors=3 | last4=Rittenhouse | first4=HG | last5=Wolfert | first5=RL | last6=Marks | first6=LS | last7=Charlesworth | first7=MC | last8=Tindall | first8=DJ }} | ||
*{{cite journal | | *{{cite journal | author=Saedi MS |title=Human kallikrein 2 (hK2), but not prostate-specific antigen (PSA), rapidly complexes with protease inhibitor 6 (PI-6) released from prostate carcinoma cells |journal=Int. J. Cancer |volume=94 |issue= 4 |pages= 558–63 |year= 2002 |pmid= 11745444 |doi=10.1002/ijc.1501 |name-list-format=vanc| author2=Zhu Z | author3=Marker K | display-authors=3 | last4=Liu | first4=Ru‐Shya | last5=Carpenter | first5=Philip M. | last6=Rittenhouse | first6=Harry | last7=Mikolajczyk | first7=Stephen D. }} | ||
*{{cite journal | author= | *{{cite journal | author=Wistow G |title=Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants |journal=Mol. Vis. |volume=8 |issue= |pages= 171–84 |year= 2002 |pmid= 12107413 |doi= |name-list-format=vanc| author2=Bernstein SL | author3=Wyatt MK | display-authors=3 | last4=Behal | first4=A | last5=Touchman | first5=JW | last6=Bouffard | first6=G | last7=Smith | first7=D | last8=Peterson | first8=K }} | ||
*{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }} | |||
*{{cite journal | author= | *{{cite journal | author=Strik MC |title=Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers |journal=Blood |volume=103 |issue= 7 |pages= 2710–7 |year= 2004 |pmid= 14670919 |doi= 10.1182/blood-2003-08-2981 |name-list-format=vanc| author2=Wolbink A | author3=Wouters D | display-authors=3 | last4=Bladergroen | first4=BA | last5=Verlaan | first5=AR | last6=Van Houdt | first6=IS | last7=Hijlkema | first7=S | last8=Hack | first8=CE | last9=Kummer | first9=JA }} | ||
*{{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki }} | |||
*{{cite journal | author= | *{{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }} | ||
*{{cite journal | author=Charron Y |title=Expression of serpinb6 serpins in germ and somatic cells of mouse gonads |journal=Mol. Reprod. Dev. |volume=73 |issue= 1 |pages= 9–19 |year= 2006 |pmid= 16175637 |doi= 10.1002/mrd.20385 |name-list-format=vanc| author2=Madani R | author3=Nef S | display-authors=3 | last4=Combepine | first4=Chantal | last5=Govin | first5=Jérôme | last6=Khochbin | first6=Saadi | last7=Vassalli | first7=Jean-Dominique }} | |||
*{{cite journal | author= | *{{cite journal | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |name-list-format=vanc| author2=Venkatesan K | author3=Hao T | display-authors=3 | last4=Hirozane-Kishikawa | first4=Tomoko | last5=Dricot | first5=Amélie | last6=Li | first6=Ning | last7=Berriz | first7=Gabriel F. | last8=Gibbons | first8=Francis D. | last9=Dreze | first9=Matija }} | ||
*{{cite journal | author= | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
==External links== | ==External links== | ||
* The [[MEROPS]] online database for peptidases and their inhibitors: [http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=I04.011 I04.011] | |||
* {{MeshName|SERPINB6+protein,+human}} | * {{MeshName|SERPINB6+protein,+human}} | ||
{{Serpins}} | {{Serpins}} | ||
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[[Category:Serine protease inhibitors]] | [[Category:Serine protease inhibitors]] | ||
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{{gene-6-stub}} |
Revision as of 06:09, 11 September 2017
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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
Wikidata | |||||||
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Serpin B6 is a protein that in humans is encoded by the SERPINB6 gene.[1][2][3]
See also
References
- ↑ Coughlin P, Sun J, Cerruti L, Salem HH, Bird P (Nov 1993). "Cloning and molecular characterization of a human intracellular serine proteinase inhibitor". Proc Natl Acad Sci U S A. 90 (20): 9417–21. doi:10.1073/pnas.90.20.9417. PMC 47579. PMID 8415716.
- ↑ Sun J, Stephens R, Mirza G, Kanai H, Ragoussis J, Bird PI (Feb 1999). "A serpin gene cluster on human chromosome 6p25 contains PI6, PI9 and ELANH2 which have a common structure almost identical to the 18q21 ovalbumin serpin genes". Cytogenet Cell Genet. 82 (3–4): 273–7. doi:10.1159/000015118. PMID 9858835.
- ↑ "Entrez Gene: SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6".
Further reading
- Sun J, Coughlin P, Salem HH, Bird P (1995). "Production and characterization of recombinant human proteinase inhibitor 6 expressed in Pichia pastoris". Biochim. Biophys. Acta. 1252 (1): 28–34. doi:10.1016/0167-4838(95)00108-7. PMID 7548163.
- Coughlin P, Nicholl J, Sun J, et al. (1995). "Chromosomal mapping of the human proteinase inhibitor 6 (PI6) gene to 6p25 by fluorescence in situ hybridization". Genomics. 26 (2): 431–3. doi:10.1016/0888-7543(95)80240-M. PMID 7601482.
- Morgenstern KA, Sprecher C, Holth L, et al. (1994). "Complementary DNA cloning and kinetic characterization of a novel intracellular serine proteinase inhibitor: mechanism of action with trypsin and factor Xa as model proteinases". Biochemistry. 33 (11): 3432–41. doi:10.1021/bi00177a037. PMID 8136380.
- Morgenstern KA, Henzel WJ, Baker JB, et al. (1993). "Isolation and characterization of an intracellular serine proteinase inhibitor from a monkey kidney epithelial cell line". J. Biol. Chem. 268 (29): 21560–8. PMID 8408007.
- Coughlin PB, Tetaz T, Salem HH (1993). "Identification and purification of a novel serine proteinase inhibitor". J. Biol. Chem. 268 (13): 9541–7. PMID 8486644.
- Riewald M, Morgenstern KA, Schleef RR (1996). "Identification and characterization of the cytoplasmic antiproteinase (CAP) in human platelets. Evidence for the interaction of CAP with endogenous platelet proteins". J. Biol. Chem. 271 (12): 7160–7. doi:10.1074/jbc.271.12.7160. PMID 8636153.
- Riewald M, Schleef RR (1996). "Human cytoplasmic antiproteinase neutralizes rapidly and efficiently chymotrypsin and trypsin-like proteases utilizing distinct reactive site residues". J. Biol. Chem. 271 (24): 14526–32. doi:10.1074/jbc.271.24.14526. PMID 8662739.
- Scott FL, Paddle-Ledinek JE, Cerruti L, et al. (1999). "Proteinase inhibitor 6 (PI-6) expression in human skin: induction of PI-6 and a PI-6/proteinase complex during keratinocyte differentiation". Exp. Cell Res. 245 (2): 263–71. doi:10.1006/excr.1998.4241. PMID 9851866.
- Mikolajczyk SD, Millar LS, Marker KM, et al. (1999). "Identification of a novel complex between human kallikrein 2 and protease inhibitor-6 in prostate cancer tissue". Cancer Res. 59 (16): 3927–30. PMID 10463585.
- Saedi MS, Zhu Z, Marker K, et al. (2002). "Human kallikrein 2 (hK2), but not prostate-specific antigen (PSA), rapidly complexes with protease inhibitor 6 (PI-6) released from prostate carcinoma cells". Int. J. Cancer. 94 (4): 558–63. doi:10.1002/ijc.1501. PMID 11745444.
- Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 171–84. PMID 12107413.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Strik MC, Wolbink A, Wouters D, et al. (2004). "Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers". Blood. 103 (7): 2710–7. doi:10.1182/blood-2003-08-2981. PMID 14670919.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Charron Y, Madani R, Nef S, et al. (2006). "Expression of serpinb6 serpins in germ and somatic cells of mouse gonads". Mol. Reprod. Dev. 73 (1): 9–19. doi:10.1002/mrd.20385. PMID 16175637.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
External links
- The MEROPS online database for peptidases and their inhibitors: I04.011
- SERPINB6+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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