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{{Infobox_gene}}
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'''Serpin B9''' is a [[protein]] that in humans is encoded by the ''SERPINB9'' [[gene]].<ref name="pmid8530382">{{cite journal |vauthors=Sprecher CA, Morgenstern KA, Mathewes S, Dahlen JR, Schrader SK, Foster DC, Kisiel W | title = Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors | journal = J Biol Chem | volume = 270 | issue = 50 | pages = 29854–61 |date=Jan 1996 | pmid = 8530382 | pmc =  | doi =10.1074/jbc.270.50.29854 }}</ref><ref name="pmid9858835">{{cite journal |vauthors=Sun J, Stephens R, Mirza G, Kanai H, Ragoussis J, Bird PI | title = A serpin gene cluster on human chromosome 6p25 contains PI6, PI9 and ELANH2 which have a common structure almost identical to the 18q21 ovalbumin serpin genes | journal = Cytogenet Cell Genet | volume = 82 | issue = 3–4 | pages = 273–7 |date=Feb 1999 | pmid = 9858835 | pmc =  | doi =10.1159/000015118 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5272| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Serpin peptidase inhibitor, clade B (ovalbumin), member 9
| HGNCid = 8955
| Symbol = SERPINB9
| AltSymbols =; CAP-3; CAP3; PI9
| OMIM = 601799
| ECnumber =
| Homologene = 37888
| MGIid = 106603
  | GeneAtlas_image1 = PBB_GE_SERPINB9_209723_at_tn.png
| GeneAtlas_image2 = PBB_GE_SERPINB9_209722_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0004867 |text = serine-type endopeptidase inhibitor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5272
    | Hs_Ensembl = ENSG00000170542
    | Hs_RefseqProtein = NP_004146
    | Hs_RefseqmRNA = NM_004155
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 2832499
    | Hs_GenLoc_end = 2848513
    | Hs_Uniprot = P50453
    | Mm_EntrezGene = 20723
    | Mm_Ensembl = ENSMUSG00000045827
    | Mm_RefseqmRNA = NM_009256
    | Mm_RefseqProtein = NP_033282
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 33012069
    | Mm_GenLoc_end = 33024343
    | Mm_Uniprot = 
  }}
}}
'''Serpin peptidase inhibitor, clade B (ovalbumin), member 9''', also known as '''SERPINB9''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5272| accessdate = }}</ref>


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{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = PI9 belongs to the large superfamily of serine proteinase inhibitors (serpins), which bind to and inactivate serine proteinases. These interactions are involved in many cellular processes, including coagulation, fibrinolysis, complement fixation, matrix remodeling, and apoptosis (Sprecher et al., 1995).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5272| accessdate = }}</ref>
| summary_text = PI9 belongs to the large superfamily of serine proteinase inhibitors (serpins), which bind to and inactivate serine proteinases. These interactions are involved in many cellular processes, including coagulation, fibrinolysis, complement fixation, matrix remodeling, and apoptosis (Sprecher et al., 1995).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5272| accessdate = }}</ref>
}}
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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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| citations =  
| citations =  
*{{cite journal | author=Sprecher CA, Morgenstern KA, Mathewes S, ''et al.'' |title=Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors. |journal=J. Biol. Chem. |volume=270 |issue= 50 |pages= 29854-61 |year= 1996 |pmid= 8530382 |doi= }}
*{{cite journal   |vauthors=Sun J, Bird CH, Sutton V, etal |title=A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes |journal=J. Biol. Chem. |volume=271 |issue= 44 |pages= 27802–9 |year= 1996 |pmid= 8910377 |doi=10.1074/jbc.271.44.27802  }}
*{{cite journal | author=Sun J, Bird CH, Sutton V, ''et al.'' |title=A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes. |journal=J. Biol. Chem. |volume=271 |issue= 44 |pages= 27802-9 |year= 1996 |pmid= 8910377 |doi=  }}
*{{cite journal   |vauthors=Annand RR, Dahlen JR, Sprecher CA, etal |title=Caspase-1 (interleukin-1beta-converting enzyme) is inhibited by the human serpin analogue proteinase inhibitor 9 |journal=Biochem. J. |volume=342 Pt 3 |issue= 3|pages= 655–65 |year= 1999 |pmid= 10477277 |doi=10.1042/0264-6021:3420655  | pmc=1220507 }}
*{{cite journal | author=Sun J, Stephens R, Mirza G, ''et al.'' |title=A serpin gene cluster on human chromosome 6p25 contains PI6, PI9 and ELANH2 which have a common structure almost identical to the 18q21 ovalbumin serpin genes. |journal=Cytogenet. Cell Genet. |volume=82 |issue= 3-4 |pages= 273-7 |year= 1999 |pmid= 9858835 |doi= }}
*{{cite journal   |vauthors=Kanamori H, Krieg S, Mao C, etal |title=Proteinase inhibitor 9, an inhibitor of granzyme B-mediated apoptosis, is a primary estrogen-inducible gene in human liver cells |journal=J. Biol. Chem. |volume=275 |issue= 8 |pages= 5867–73 |year= 2000 |pmid= 10681578 |doi=10.1074/jbc.275.8.5867  }}
*{{cite journal | author=Annand RR, Dahlen JR, Sprecher CA, ''et al.'' |title=Caspase-1 (interleukin-1beta-converting enzyme) is inhibited by the human serpin analogue proteinase inhibitor 9. |journal=Biochem. J. |volume=342 Pt 3 |issue= |pages= 655-65 |year= 1999 |pmid= 10477277 |doi=  }}
*{{cite journal   |vauthors=Bladergroen BA, Strik MC, Bovenschen N, etal |title=The granzyme B inhibitor, protease inhibitor 9, is mainly expressed by dendritic cells and at immune-privileged sites |journal=J. Immunol. |volume=166 |issue= 5 |pages= 3218–25 |year= 2001 |pmid= 11207275 |doi=  10.4049/jimmunol.166.5.3218}}
*{{cite journal | author=Kanamori H, Krieg S, Mao C, ''et al.'' |title=Proteinase inhibitor 9, an inhibitor of granzyme B-mediated apoptosis, is a primary estrogen-inducible gene in human liver cells. |journal=J. Biol. Chem. |volume=275 |issue= 8 |pages= 5867-73 |year= 2000 |pmid= 10681578 |doi= }}
*{{cite journal   |vauthors=Buzza MS, Hirst CE, Bird CH, etal |title=The granzyme B inhibitor, PI-9, is present in endothelial and mesothelial cells, suggesting that it protects bystander cells during immune responses |journal=Cell. Immunol. |volume=210 |issue= 1 |pages= 21–9 |year= 2001 |pmid= 11485349 |doi= 10.1006/cimm.2001.1806 }}
*{{cite journal | author=Bladergroen BA, Strik MC, Bovenschen N, ''et al.'' |title=The granzyme B inhibitor, protease inhibitor 9, is mainly expressed by dendritic cells and at immune-privileged sites. |journal=J. Immunol. |volume=166 |issue= 5 |pages= 3218-25 |year= 2001 |pmid= 11207275 |doi=  }}
*{{cite journal   |vauthors=Hirst CE, Buzza MS, Sutton VR, etal |title=Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction |journal=Mol. Hum. Reprod. |volume=7 |issue= 12 |pages= 1133–42 |year= 2002 |pmid= 11719590 |doi=10.1093/molehr/7.12.1133 }}
*{{cite journal | author=Buzza MS, Hirst CE, Bird CH, ''et al.'' |title=The granzyme B inhibitor, PI-9, is present in endothelial and mesothelial cells, suggesting that it protects bystander cells during immune responses. |journal=Cell. Immunol. |volume=210 |issue= 1 |pages= 21-9 |year= 2001 |pmid= 11485349 |doi= 10.1006/cimm.2001.1806 }}
*{{cite journal   |vauthors=Tanaka K, Harashima N, Niiya F, etal |title=Serine proteinase inhibitor 9 can be recognized by cytotoxic T lymphocytes of epithelial cancer patients |journal=Jpn. J. Cancer Res. |volume=93 |issue= 2 |pages= 198–208 |year= 2002 |pmid= 11856484 |doi= 10.1111/j.1349-7006.2002.tb01259.x}}
*{{cite journal | author=Hirst CE, Buzza MS, Sutton VR, ''et al.'' |title=Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction. |journal=Mol. Hum. Reprod. |volume=7 |issue= 12 |pages= 1133-42 |year= 2002 |pmid= 11719590 |doi=  }}
*{{cite journal   |vauthors=ten Berge RL, Meijer CJ, Dukers DF, etal |title=Expression levels of apoptosis-related proteins predict clinical outcome in anaplastic large cell lymphoma |journal=Blood |volume=99 |issue= 12 |pages= 4540–6 |year= 2002 |pmid= 12036886 |doi=10.1182/blood.V99.12.4540 }}
*{{cite journal | author=Tanaka K, Harashima N, Niiya F, ''et al.'' |title=Serine proteinase inhibitor 9 can be recognized by cytotoxic T lymphocytes of epithelial cancer patients. |journal=Jpn. J. Cancer Res. |volume=93 |issue= 2 |pages= 198-208 |year= 2002 |pmid= 11856484 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=ten Berge RL, Meijer CJ, Dukers DF, ''et al.'' |title=Expression levels of apoptosis-related proteins predict clinical outcome in anaplastic large cell lymphoma. |journal=Blood |volume=99 |issue= 12 |pages= 4540-6 |year= 2002 |pmid= 12036886 |doi=  }}
*{{cite journal   |vauthors=Hirst CE, Buzza MS, Bird CH, etal |title=The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency |journal=J. Immunol. |volume=170 |issue= 2 |pages= 805–15 |year= 2003 |pmid= 12517944 |doi=  10.4049/jimmunol.170.2.805}}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Rowshani AT, Florquin S, Bemelman F, etal |title=Hyperexpression of the granzyme B inhibitor PI-9 in human renal allografts: a potential mechanism for stable renal function in patients with subclinical rejection |journal=Kidney Int. |volume=66 |issue= 4 |pages= 1417–22 |year= 2005 |pmid= 15458434 |doi= 10.1111/j.1523-1755.2004.00903.x }}
*{{cite journal | author=Hirst CE, Buzza MS, Bird CH, ''et al.'' |title=The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency. |journal=J. Immunol. |volume=170 |issue= 2 |pages= 805-15 |year= 2003 |pmid= 12517944 |doi=  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal  | author=Rowshani AT, Florquin S, Bemelman F, ''et al.'' |title=Hyperexpression of the granzyme B inhibitor PI-9 in human renal allografts: a potential mechanism for stable renal function in patients with subclinical rejection. |journal=Kidney Int. |volume=66 |issue= 4 |pages= 1417-22 |year= 2005 |pmid= 15458434 |doi= 10.1111/j.1523-1755.2004.00903.x }}
*{{cite journal  |vauthors=Mahrus S, Kisiel W, Craik CS |title=Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B |journal=J. Biol. Chem. |volume=279 |issue= 52 |pages= 54275–82 |year= 2005 |pmid= 15494398 |doi= 10.1074/jbc.M411482200 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Classen CF, Ushmorov A, Bird P, Debatin KM |title=The granzyme B inhibitor PI-9 is differentially expressed in all main subtypes of pediatric acute lymphoblastic leukemias |journal=Haematologica |volume=89 |issue= 11 |pages= 1314–21 |year= 2006 |pmid= 15531453 |doi=  }}
*{{cite journal  | author=Mahrus S, Kisiel W, Craik CS |title=Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B. |journal=J. Biol. Chem. |volume=279 |issue= 52 |pages= 54275-82 |year= 2005 |pmid= 15494398 |doi= 10.1074/jbc.M411482200 }}
*{{cite journal   |vauthors=Bruneel A, Labas V, Mailloux A, etal |title=Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis |journal=Proteomics |volume=5 |issue= 15 |pages= 3876–84 |year= 2006 |pmid= 16130169 |doi= 10.1002/pmic.200401239 }}
*{{cite journal  | author=Classen CF, Ushmorov A, Bird P, Debatin KM |title=The granzyme B inhibitor PI-9 is differentially expressed in all main subtypes of pediatric acute lymphoblastic leukemias. |journal=Haematologica |volume=89 |issue= 11 |pages= 1314-21 |year= 2006 |pmid= 15531453 |doi=  }}
*{{cite journal   |vauthors=van Houdt IS, Oudejans JJ, van den Eertwegh AJ, etal |title=Expression of the apoptosis inhibitor protease inhibitor 9 predicts clinical outcome in vaccinated patients with stage III and IV melanoma |journal=Clin. Cancer Res. |volume=11 |issue= 17 |pages= 6400–7 |year= 2005 |pmid= 16144945 |doi= 10.1158/1078-0432.CCR-05-0306 }}
*{{cite journal | author=Bruneel A, Labas V, Mailloux A, ''et al.'' |title=Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. |journal=Proteomics |volume=5 |issue= 15 |pages= 3876-84 |year= 2006 |pmid= 16130169 |doi= 10.1002/pmic.200401239 }}
*{{cite journal   |vauthors=Stelzl U, Worm U, Lalowski M, etal |title=A human protein-protein interaction network: a resource for annotating the proteome |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal | author=van Houdt IS, Oudejans JJ, van den Eertwegh AJ, ''et al.'' |title=Expression of the apoptosis inhibitor protease inhibitor 9 predicts clinical outcome in vaccinated patients with stage III and IV melanoma. |journal=Clin. Cancer Res. |volume=11 |issue= 17 |pages= 6400-7 |year= 2005 |pmid= 16144945 |doi= 10.1158/1078-0432.CCR-05-0306 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
}}
{{refend}}
{{refend}}


==External links==
==External links==
* The [[MEROPS]] online database for peptidases and their inhibitors: [http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=I04.014 I04.014]
* {{MeshName|SERPINB9+protein,+human}}
* {{MeshName|SERPINB9+protein,+human}}


{{protein-stub}}
{{NLM content}}
{{NLM content}}
{{Serpins}}
{{Serpins}}
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[[Category:Serine protease inhibitors]]
[[Category:Serine protease inhibitors]]
{{WikiDoc Sources}}
 
 
{{gene-6-stub}}

Latest revision as of 06:09, 11 September 2017

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Wikidata
View/Edit Human

Serpin B9 is a protein that in humans is encoded by the SERPINB9 gene.[1][2][3]

PI9 belongs to the large superfamily of serine proteinase inhibitors (serpins), which bind to and inactivate serine proteinases. These interactions are involved in many cellular processes, including coagulation, fibrinolysis, complement fixation, matrix remodeling, and apoptosis (Sprecher et al., 1995).[supplied by OMIM][3]

See also

References

  1. ↑ Sprecher CA, Morgenstern KA, Mathewes S, Dahlen JR, Schrader SK, Foster DC, Kisiel W (Jan 1996). "Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors". J Biol Chem. 270 (50): 29854–61. doi:10.1074/jbc.270.50.29854. PMID 8530382.
  2. ↑ Sun J, Stephens R, Mirza G, Kanai H, Ragoussis J, Bird PI (Feb 1999). "A serpin gene cluster on human chromosome 6p25 contains PI6, PI9 and ELANH2 which have a common structure almost identical to the 18q21 ovalbumin serpin genes". Cytogenet Cell Genet. 82 (3–4): 273–7. doi:10.1159/000015118. PMID 9858835.
  3. ↑ 3.0 3.1 "Entrez Gene: SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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