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{{Infobox_gene}}
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'''Proto-oncogene tyrosine-protein kinase Yes''' is an [[enzyme]] that in humans is encoded by the ''YES1'' [[gene]].<ref name="pmid2983418">{{cite journal |vauthors=Semba K, Yamanashi Y, Nishizawa M, Sukegawa J, Yoshida M, Sasaki M, Yamamoto T, Toyoshima K | title = Location of the c-yes gene on the human chromosome and its expression in various tissues | journal = Science | volume = 227 | issue = 4690 | pages = 1038–40 |date=Mar 1985 | pmid = 2983418 | pmc =  | doi =10.1126/science.2983418 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: YES1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7525| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_YES1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2hda.
| PDB = {{PDB2|2hda}}, {{PDB2|2hwo}}, {{PDB2|2hwp}}, {{PDB2|2oiq}}
| Name = V-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
| HGNCid = 12841
| Symbol = YES1
| AltSymbols =; HsT441; P61-YES; Yes; c-yes
| OMIM = 164880
| ECnumber =
| Homologene = 55900
| MGIid = 99147
  | GeneAtlas_image1 = PBB_GE_YES1_202933_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_YES1_202932_at_tn.png
  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7525
    | Hs_Ensembl = ENSG00000176105
    | Hs_RefseqProtein = NP_005424
    | Hs_RefseqmRNA = NM_005433
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 18
    | Hs_GenLoc_start = 711747
    | Hs_GenLoc_end = 802547
    | Hs_Uniprot = P07947
    | Mm_EntrezGene = 22612
    | Mm_Ensembl = ENSMUSG00000014932
    | Mm_RefseqmRNA = NM_009535
    | Mm_RefseqProtein = NP_033561
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 32887814
    | Mm_GenLoc_end = 32963638
    | Mm_Uniprot = Q3TJI7
  }}
}}
'''V-yes-1 Yamaguchi sarcoma viral oncogene homolog 1''', also known as '''YES1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: YES1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7525| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22.<ref name="entrez">{{cite web | title = Entrez Gene: YES1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7525| accessdate = }}</ref>
| summary_text = This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22.<ref name="entrez"/>
}}
}}
==Interactions==
YES1 has been shown to [[Protein-protein interaction|interact]] with [[Janus kinase 2]],<ref name=pmid8702385>{{cite journal |last=Fuhrer |first=D K |authorlink= |author2=Yang Y C  |date=Jul 1996 |title=Complex formation of JAK2 with PP2A, P13K, and Yes in response to the hematopoietic cytokine interleukin-11 |journal=Biochem. Biophys. Res. Commun. |volume=224 |issue=2 |pages=289–96 |publisher= |location = UNITED STATES| issn = 0006-291X| pmid = 8702385 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1006/bbrc.1996.1023 }}</ref> [[CTNND1]],<ref name=pmid12640114>{{cite journal |last=Piedra |first=Jose |authorlink= |author2=Miravet Susana |author3=Castaño Julio |author4=Pálmer Héctor G |author5=Heisterkamp Nora |author6=García de Herreros Antonio |author7=Duñach Mireia  |date=Apr 2003 |title=p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction |journal=Mol. Cell. Biol. |volume=23 |issue=7 |pages=2287–97 |publisher= |location = United States| issn = 0270-7306| pmid = 12640114 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1128/MCB.23.7.2287-2297.2003 |pmc=150740 }}</ref> [[RPL10]]<ref name=pmid12138090>{{cite journal |last=Oh |first=Hyung Suk |authorlink= |author2=Kwon Haeyoung |author3=Sun Suk Kyun |author4=Yang Chul-Hak  |date=Sep 2002 |title=QM, a putative tumor suppressor, regulates proto-oncogene c-yes |journal=J. Biol. Chem. |volume=277 |issue=39 |pages=36489–98 |publisher= |location = United States| issn = 0021-9258| pmid = 12138090 |doi = 10.1074/jbc.M201859200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[Occludin]].<ref name=pmid11950934>{{cite journal |last=Chen |first=Yan-Hua |authorlink= |author2=Lu Qun |author3=Goodenough Daniel A |author4=Jeansonne Beverly  |date=Apr 2002 |title=Nonreceptor tyrosine kinase c-Yes interacts with occludin during tight junction formation in canine kidney epithelial cells |journal=Mol. Biol. Cell |volume=13 |issue=4 |pages=1227–37 |publisher= |location = United States| issn = 1059-1524| pmid = 11950934 |doi = 10.1091/mbc.01-08-0423 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=102264 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Brickell PM |title=The p60c-src family of protein-tyrosine kinases: structure, regulation, and function. |journal=Critical reviews in oncogenesis |volume=3 |issue= 4 |pages= 401-46 |year= 1992 |pmid= 1384720 |doi=  }}
*{{cite journal  | author=Brickell PM |title=The p60c-src family of protein-tyrosine kinases: structure, regulation, and function. |journal=Critical reviews in oncogenesis |volume=3 |issue= 4 |pages= 401–46 |year= 1992 |pmid= 1384720 |doi=  }}
*{{cite journal | author=Toyoshima K, Semba K, Nishizawa M, ''et al.'' |title=Nakahara memorial lecture. Non-receptor type protein-tyrosine kinases closely related to src and yes compose a multigene family. |journal=Int. Symp. Princess Takamatsu Cancer Res. Fund |volume=17 |issue=  |pages= 11-20 |year= 1988 |pmid= 3332005 |doi=  }}
*{{cite journal   |vauthors=Toyoshima K, Semba K, Nishizawa M, etal |title=Nakahara memorial lecture. Non-receptor type protein-tyrosine kinases closely related to src and yes compose a multigene family. |journal=Int. Symp. Princess Takamatsu Cancer Res. Fund |volume=17 |issue=  |pages= 11–20 |year= 1988 |pmid= 3332005 |doi=  }}
*{{cite journal | author=Sudol M, Chen HI, Bougeret C, ''et al.'' |title=Characterization of a novel protein-binding module--the WW domain. |journal=FEBS Lett. |volume=369 |issue= 1 |pages= 67-71 |year= 1995 |pmid= 7641887 |doi=  }}
*{{cite journal   |vauthors=Sudol M, Chen HI, Bougeret C, etal |title=Characterization of a novel protein-binding module--the WW domain. |journal=FEBS Lett. |volume=369 |issue= 1 |pages= 67–71 |year= 1995 |pmid= 7641887 |doi=10.1016/0014-5793(95)00550-S }}
*{{cite journal | author=Summy JM, Sudol M, Eck MJ, ''et al.'' |title=Specificity in signaling by c-Yes. |journal=Front. Biosci. |volume=8 |issue=  |pages= s185-205 |year= 2004 |pmid= 12456296 |doi=  }}
*{{cite journal   |vauthors=Summy JM, Sudol M, Eck MJ, etal |title=Specificity in signaling by c-Yes. |journal=Front. Biosci. |volume=8 |issue=  |pages= s185–205 |year= 2004 |pmid= 12456296 |doi=10.2741/1011 }}
*{{cite journal  | author=Cichowski K, McCormick F, Brugge JS |title=p21rasGAP association with Fyn, Lyn, and Yes in thrombin-activated platelets. |journal=J. Biol. Chem. |volume=267 |issue= 8 |pages= 5025-8 |year= 1992 |pmid= 1544885 |doi=  }}
*{{cite journal  |vauthors=Cichowski K, McCormick F, Brugge JS |title=p21rasGAP association with Fyn, Lyn, and Yes in thrombin-activated platelets. |journal=J. Biol. Chem. |volume=267 |issue= 8 |pages= 5025–8 |year= 1992 |pmid= 1544885 |doi=  }}
*{{cite journal | author=Huang MM, Bolen JB, Barnwell JW, ''et al.'' |title=Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 17 |pages= 7844-8 |year= 1991 |pmid= 1715582 |doi=  }}
*{{cite journal   |vauthors=Huang MM, Bolen JB, Barnwell JW, etal |title=Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 17 |pages= 7844–8 |year= 1991 |pmid= 1715582 |doi=10.1073/pnas.88.17.7844  | pmc=52400 }}
*{{cite journal  | author=Holtrich U, Bräuninger A, Strebhardt K, Rübsamen-Waigmann H |title=Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 23 |pages= 10411-5 |year= 1992 |pmid= 1720539 |doi=  }}
*{{cite journal  |vauthors=Holtrich U, Bräuninger A, Strebhardt K, Rübsamen-Waigmann H |title=Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 23 |pages= 10411–5 |year= 1992 |pmid= 1720539 |doi=10.1073/pnas.88.23.10411  | pmc=52938 }}
*{{cite journal  | author=Krueger J, Zhao YH, Murphy D, Sudol M |title=Differential expression of p62c-yes in normal, hyperplastic and neoplastic human epidermis. |journal=Oncogene |volume=6 |issue= 6 |pages= 933-40 |year= 1991 |pmid= 2067846 |doi=  }}
*{{cite journal  |vauthors=Krueger J, Zhao YH, Murphy D, Sudol M |title=Differential expression of p62c-yes in normal, hyperplastic and neoplastic human epidermis. |journal=Oncogene |volume=6 |issue= 6 |pages= 933–40 |year= 1991 |pmid= 2067846 |doi=  }}
*{{cite journal  | author=Zhao YH, Krueger JG, Sudol M |title=Expression of cellular-yes protein in mammalian tissues. |journal=Oncogene |volume=5 |issue= 11 |pages= 1629-35 |year= 1991 |pmid= 2267131 |doi=  }}
*{{cite journal  |vauthors=Zhao YH, Krueger JG, Sudol M |title=Expression of cellular-yes protein in mammalian tissues. |journal=Oncogene |volume=5 |issue= 11 |pages= 1629–35 |year= 1991 |pmid= 2267131 |doi=  }}
*{{cite journal | author=Sukegawa J, Semba K, Yamanashi Y, ''et al.'' |title=Characterization of cDNA clones for the human c-yes gene. |journal=Mol. Cell. Biol. |volume=7 |issue= 1 |pages= 41-7 |year= 1987 |pmid= 2436037 |doi= }}
*{{cite journal   |vauthors=Sukegawa J, Semba K, Yamanashi Y, etal |title=Characterization of cDNA clones for the human c-yes gene. |journal=Mol. Cell. Biol. |volume=7 |issue= 1 |pages= 41–7 |year= 1987 |pmid= 2436037 |doi=  | pmc=365039 }}
*{{cite journal | author=Semba K, Yamanashi Y, Nishizawa M, ''et al.'' |title=Location of the c-yes gene on the human chromosome and its expression in various tissues. |journal=Science |volume=227 |issue= 4690 |pages= 1038-40 |year= 1985 |pmid= 2983418 |doi=  }}
*{{cite journal  |vauthors=Bull HA, Brickell PM, Dowd PM |title=Src-related protein tyrosine kinases are physically associated with the surface antigen CD36 in human dermal microvascular endothelial cells. |journal=FEBS Lett. |volume=351 |issue= 1 |pages= 41–4 |year= 1994 |pmid= 7521304 |doi=10.1016/0014-5793(94)00814-0 }}
*{{cite journal  | author=Bull HA, Brickell PM, Dowd PM |title=Src-related protein tyrosine kinases are physically associated with the surface antigen CD36 in human dermal microvascular endothelial cells. |journal=FEBS Lett. |volume=351 |issue= 1 |pages= 41-4 |year= 1994 |pmid= 7521304 |doi=  }}
*{{cite journal  |vauthors=Toshima J, Ohashi K, Iwashita S, Mizuno K |title=Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase. |journal=Biochem. Biophys. Res. Commun. |volume=209 |issue= 2 |pages= 656–63 |year= 1995 |pmid= 7537495 |doi= 10.1006/bbrc.1995.1549 }}
*{{cite journal  | author=Toshima J, Ohashi K, Iwashita S, Mizuno K |title=Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase. |journal=Biochem. Biophys. Res. Commun. |volume=209 |issue= 2 |pages= 656-63 |year= 1995 |pmid= 7537495 |doi= 10.1006/bbrc.1995.1549 }}
*{{cite journal   |vauthors=Courtneidge SA, Dhand R, Pilat D, etal |title=Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor. |journal=EMBO J. |volume=12 |issue= 3 |pages= 943–50 |year= 1993 |pmid= 7681396 |doi= | pmc=413295 }}
*{{cite journal | author=Courtneidge SA, Dhand R, Pilat D, ''et al.'' |title=Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor. |journal=EMBO J. |volume=12 |issue= 3 |pages= 943-50 |year= 1993 |pmid= 7681396 |doi=  }}
*{{cite journal   |vauthors=Mori S, Rönnstrand L, Yokote K, etal |title=Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases. |journal=EMBO J. |volume=12 |issue= 6 |pages= 2257–64 |year= 1993 |pmid= 7685273 |doi= | pmc=413454 }}
*{{cite journal | author=Mori S, Rönnstrand L, Yokote K, ''et al.'' |title=Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases. |journal=EMBO J. |volume=12 |issue= 6 |pages= 2257-64 |year= 1993 |pmid= 7685273 |doi=  }}
*{{cite journal   |vauthors=Waltenberger J, Claesson-Welsh L, Siegbahn A, etal |title=Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. |journal=J. Biol. Chem. |volume=269 |issue= 43 |pages= 26988–95 |year= 1994 |pmid= 7929439 |doi=  }}
*{{cite journal | author=Waltenberger J, Claesson-Welsh L, Siegbahn A, ''et al.'' |title=Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. |journal=J. Biol. Chem. |volume=269 |issue= 43 |pages= 26988-95 |year= 1994 |pmid= 7929439 |doi=  }}
*{{cite journal  |vauthors=Silverman GA, Kuo WL, Taillon-Miller P, Gray JW |title=Chromosomal reassignment: YACs containing both YES1 and thymidylate synthase map to the short arm of chromosome 18. |journal=Genomics |volume=15 |issue= 2 |pages= 442–5 |year= 1993 |pmid= 8449516 |doi= 10.1006/geno.1993.1086 }}
*{{cite journal  | author=Silverman GA, Kuo WL, Taillon-Miller P, Gray JW |title=Chromosomal reassignment: YACs containing both YES1 and thymidylate synthase map to the short arm of chromosome 18. |journal=Genomics |volume=15 |issue= 2 |pages= 442-5 |year= 1993 |pmid= 8449516 |doi= 10.1006/geno.1993.1086 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=7525}}
{{Tyrosine kinases}}
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Revision as of 22:16, 18 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Proto-oncogene tyrosine-protein kinase Yes is an enzyme that in humans is encoded by the YES1 gene.[1][2]

This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22.[2]

Interactions

YES1 has been shown to interact with Janus kinase 2,[3] CTNND1,[4] RPL10[5] and Occludin.[6]

References

  1. ↑ Semba K, Yamanashi Y, Nishizawa M, Sukegawa J, Yoshida M, Sasaki M, Yamamoto T, Toyoshima K (Mar 1985). "Location of the c-yes gene on the human chromosome and its expression in various tissues". Science. 227 (4690): 1038–40. doi:10.1126/science.2983418. PMID 2983418.
  2. ↑ 2.0 2.1 "Entrez Gene: YES1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1".
  3. ↑ Fuhrer, D K; Yang Y C (Jul 1996). "Complex formation of JAK2 with PP2A, P13K, and Yes in response to the hematopoietic cytokine interleukin-11". Biochem. Biophys. Res. Commun. UNITED STATES. 224 (2): 289–96. doi:10.1006/bbrc.1996.1023. ISSN 0006-291X. PMID 8702385.
  4. ↑ Piedra, Jose; Miravet Susana; Castaño Julio; Pálmer Héctor G; Heisterkamp Nora; García de Herreros Antonio; Duñach Mireia (Apr 2003). "p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction". Mol. Cell. Biol. United States. 23 (7): 2287–97. doi:10.1128/MCB.23.7.2287-2297.2003. ISSN 0270-7306. PMC 150740. PMID 12640114.
  5. ↑ Oh, Hyung Suk; Kwon Haeyoung; Sun Suk Kyun; Yang Chul-Hak (Sep 2002). "QM, a putative tumor suppressor, regulates proto-oncogene c-yes". J. Biol. Chem. United States. 277 (39): 36489–98. doi:10.1074/jbc.M201859200. ISSN 0021-9258. PMID 12138090.
  6. ↑ Chen, Yan-Hua; Lu Qun; Goodenough Daniel A; Jeansonne Beverly (Apr 2002). "Nonreceptor tyrosine kinase c-Yes interacts with occludin during tight junction formation in canine kidney epithelial cells". Mol. Biol. Cell. United States. 13 (4): 1227–37. doi:10.1091/mbc.01-08-0423. ISSN 1059-1524. PMC 102264. PMID 11950934.

Further reading



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