YWHAE: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''14-3-3 protein epsilon''' is a [[protein]] that in humans is encoded by the ''YWHAE'' [[gene]].<ref name="pmid9371399">{{cite journal | vauthors = Luk SC, Garcia-Barcelo M, Tsui SK, Fung KP, Lee CY, Waye MM | title = Assignment of the human 14-3-3 epsilon isoform (YWHAE) to human chromosome 17p13 by in situ hybridization | journal = Cytogenet Cell Genet | volume = 78 | issue = 2 | pages = 105–6 | date = December 1997 | pmid = 9371399 | pmc = | doi = 10.1159/000134638 }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_YWHAE_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2br9.
| PDB = {{PDB2|2br9}}
| Name = Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
| HGNCid = 12851
| Symbol = YWHAE
| AltSymbols =; MDCR; MDS; KCIP-1; 14-3-3E; FLJ45465
| OMIM = 605066
| ECnumber = 
| Homologene = 38223
| MGIid = 894689
| GeneAtlas_image1 = PBB_GE_YWHAE_210317_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_YWHAE_210996_s_at_tn.png
| Function = {{GNF_GO|id=GO:0019899 |text = enzyme binding}} {{GNF_GO|id=GO:0019904 |text = protein domain specific binding}}
| Component =
| Process = {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7531
    | Hs_Ensembl = ENSG00000108953
    | Hs_RefseqProtein = XP_001126863
    | Hs_RefseqmRNA = XM_001126863
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 1194558
    | Hs_GenLoc_end = 1250231
    | Hs_Uniprot = P62258
    | Mm_EntrezGene = 22627
    | Mm_Ensembl = ENSMUSG00000020849
    | Mm_RefseqmRNA = NM_009536
    | Mm_RefseqProtein = NP_033562
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 75549134
    | Mm_GenLoc_end = 75582033
    | Mm_Uniprot = Q3V453
  }}
}}
'''Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide''', also known as '''YWHAE''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene product belongs to the [[14-3-3]] family of proteins which mediate [[signal transduction]] by binding to [[phosphoserine]]-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, [[RAF1]] and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of [[insulin sensitivity]]. It has also been implicated in the pathogenesis of [[small cell lung cancer]].<ref>{{cite web | title = Entrez Gene: YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7531| accessdate = }}</ref>
{{PBB_Summary
 
| section_title =
== Interactions ==
| summary_text = This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer.<ref>{{cite web | title = Entrez Gene: YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7531| accessdate = }}</ref>
 
}}
YWHAE has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[C-Raf]],<ref name = pmid7644510/><ref name = pmid8702721>{{cite journal | vauthors = Vincenz C, Dixit VM | title = 14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules | journal = J. Biol. Chem. | volume = 271 | issue = 33 | pages = 20029–34 | date = August 1996 | pmid = 8702721 | doi =  10.1074/jbc.271.33.20029}}</ref>
* [[CDC25B]],<ref name = pmid10713667>{{cite journal | vauthors = Mils V, Baldin V, Goubin F, Pinta I, Papin C, Waye M, Eychene A, Ducommun B | title = Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase | journal = Oncogene | volume = 19 | issue = 10 | pages = 1257–65 | date = March 2000 | pmid = 10713667 | doi = 10.1038/sj.onc.1203419 }}</ref><ref name = pmid7644510>{{cite journal | vauthors = Conklin DS, Galaktionov K, Beach D | title = 14-3-3 proteins associate with cdc25 phosphatases | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 92 | issue = 17 | pages = 7892–6 | date = August 1995 | pmid = 7644510 | pmc = 41252 | doi =  10.1073/pnas.92.17.7892}}</ref>
* [[HDAC4]],<ref name = pmid11504882>{{cite journal | vauthors = Miska EA, Langley E, Wolf D, Karlsson C, Pines J, Kouzarides T | title = Differential localization of HDAC4 orchestrates muscle differentiation | journal = Nucleic Acids Res. | volume = 29 | issue = 16 | pages = 3439–47 | date = August 2001 | pmid = 11504882 | pmc = 55849 | doi =  10.1093/nar/29.16.3439}}</ref><ref name = pmid10869435>{{cite journal | vauthors = Grozinger CM, Schreiber SL | title = Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 14 | pages = 7835–40 | date = July 2000 | pmid = 10869435 | pmc = 16631 | doi = 10.1073/pnas.140199597 }}</ref>
* [[HERG]],<ref name = pmid11953308>{{cite journal | vauthors = Kagan A, Melman YF, Krumerman A, McDonald TV | title = 14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity | journal = EMBO J. | volume = 21 | issue = 8 | pages = 1889–98 | date = April 2002 | pmid = 11953308 | pmc = 125975 | doi = 10.1093/emboj/21.8.1889 }}</ref>
* [[IRS1]]<ref name = pmid9111084/> and
* [[Insulin-like growth factor 1 receptor|IGF1R]],<ref name = pmid9111084>{{cite journal | vauthors = Craparo A, Freund R, Gustafson TA | title = 14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner | journal = J. Biol. Chem. | volume = 272 | issue = 17 | pages = 11663–9 | date = April 1997 | pmid = 9111084 | doi =  10.1074/jbc.272.17.11663}}</ref>
* [[MAP3K3]],<ref name = pmid9452471>{{cite journal | vauthors = Fanger GR, Widmann C, Porter AC, Sather S, Johnson GL, Vaillancourt RR | title = 14-3-3 proteins interact with specific MEK kinases | journal = J. Biol. Chem. | volume = 273 | issue = 6 | pages = 3476–83 | date = February 1998 | pmid = 9452471 | doi =  10.1074/jbc.273.6.3476}}</ref>
* [[NDEL1]],<ref name = pmid12796778>{{cite journal | vauthors = Toyo-oka K, Shionoya A, Gambello MJ, Cardoso C, Leventer R, Ward HL, Ayala R, Tsai LH, Dobyns W, Ledbetter D, Hirotsune S, Wynshaw-Boris A | title = 14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome | journal = Nat. Genet. | volume = 34 | issue = 3 | pages = 274–85 | date = July 2003 | pmid = 12796778 | doi = 10.1038/ng1169 }}</ref>
* [[NGFRAP1]],<ref name = pmid11278287>{{cite journal | vauthors = Kimura MT, Irie S, Shoji-Hoshino S, Mukai J, Nadano D, Oshimura M, Sato TA | title = 14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction | journal = J. Biol. Chem. | volume = 276 | issue = 20 | pages = 17291–300 | date = May 2001 | pmid = 11278287 | doi = 10.1074/jbc.M005453200 }}</ref>  and
* [[TGF beta 1]].<ref name = pmid11172812>{{cite journal | vauthors = McGonigle S, Beall MJ, Feeney EL, Pearce EJ | title = Conserved role for 14-3-3epsilon downstream of type I TGFbeta receptors | journal = FEBS Lett. | volume = 490 | issue = 1-2 | pages = 65–9 | date = February 2001 | pmid = 11172812 | doi =  10.1016/S0014-5793(01)02133-0}}</ref>
{{Div col end}}


==See also==
==See also==
Line 59: Line 26:


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal | vauthors = Kino T, Pavlakis GN | title = Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1 | journal = DNA Cell Biol. | volume = 23 | issue = 4 | pages = 193–205 | year = 2004 | pmid = 15142377 | doi = 10.1089/104454904773819789 }}
| citations =
*{{cite journal | vauthors = Kino T, Chrousos GP | title = Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome? | journal = Ann. N. Y. Acad. Sci. | volume = 1024 | issue =  | pages = 153–67 | year = 2004 | pmid = 15265780 | doi = 10.1196/annals.1321.013 }}
*{{cite journal | author=Kino T, Pavlakis GN |title=Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1. |journal=DNA Cell Biol. |volume=23 |issue= 4 |pages= 193-205 |year= 2004 |pmid= 15142377 |doi= 10.1089/104454904773819789 }}
*{{cite journal | vauthors = Jones DH, Ley S, Aitken A | title = Isoforms of 14-3-3 protein can form homo- and heterodimers in vivo and in vitro: implications for function as adapter proteins | journal = FEBS Lett. | volume = 368 | issue = 1 | pages = 55–8 | year = 1995 | pmid = 7615088 | doi = 10.1016/0014-5793(95)00598-4 }}
*{{cite journal | author=Kino T, Chrousos GP |title=Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome? |journal=Ann. N. Y. Acad. Sci. |volume=1024 |issue=  |pages= 153-67 |year= 2004 |pmid= 15265780 |doi= 10.1196/annals.1321.013 }}
*{{cite journal | vauthors = Conklin DS, Galaktionov K, Beach D | title = 14-3-3 proteins associate with cdc25 phosphatases | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 92 | issue = 17 | pages = 7892–6 | year = 1995 | pmid = 7644510 | pmc = 41252 | doi = 10.1073/pnas.92.17.7892 }}
*{{cite journal | author=Jones DH, Ley S, Aitken A |title=Isoforms of 14-3-3 protein can form homo- and heterodimers in vivo and in vitro: implications for function as adapter proteins. |journal=FEBS Lett. |volume=368 |issue= 1 |pages= 55-8 |year= 1995 |pmid= 7615088 |doi= }}
*{{cite journal | vauthors = Jin DY, Lyu MS, Kozak CA, Jeang KT | title = Function of 14-3-3 proteins | journal = Nature | volume = 382 | issue = 6589 | pages = 308 | year = 1996 | pmid = 8684458 | doi = 10.1038/382308a0 }}
*{{cite journal | author=Conklin DS, Galaktionov K, Beach D |title=14-3-3 proteins associate with cdc25 phosphatases. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 17 |pages= 7892-6 |year= 1995 |pmid= 7644510 |doi= }}
*{{cite journal | vauthors = Vincenz C, Dixit VM | title = 14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules | journal = J. Biol. Chem. | volume = 271 | issue = 33 | pages = 20029–34 | year = 1996 | pmid = 8702721 | doi = 10.1074/jbc.271.33.20029 }}
*{{cite journal | author=Jin DY, Lyu MS, Kozak CA, Jeang KT |title=Function of 14-3-3 proteins. |journal=Nature |volume=382 |issue= 6589 |pages= 308 |year= 1996 |pmid= 8684458 |doi= 10.1038/382308a0 }}
*{{cite journal | vauthors = Chong SS, Tanigami A, Roschke AV, Ledbetter DH | title = 14-3-3 epsilon has no homology to LIS1 and lies telomeric to it on chromosome 17p13.3 outside the Miller-Dieker syndrome chromosome region | journal = Genome Res. | volume = 6 | issue = 8 | pages = 735–41 | year = 1997 | pmid = 8858348 | doi = 10.1101/gr.6.8.735 }}
*{{cite journal | author=Vincenz C, Dixit VM |title=14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules. |journal=J. Biol. Chem. |volume=271 |issue= 33 |pages= 20029-34 |year= 1996 |pmid= 8702721 |doi= }}
*{{cite journal | vauthors = Craparo A, Freund R, Gustafson TA | title = 14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner | journal = J. Biol. Chem. | volume = 272 | issue = 17 | pages = 11663–9 | year = 1997 | pmid = 9111084 | doi = 10.1074/jbc.272.17.11663 }}
*{{cite journal | author=Chong SS, Tanigami A, Roschke AV, Ledbetter DH |title=14-3-3 epsilon has no homology to LIS1 and lies telomeric to it on chromosome 17p13.3 outside the Miller-Dieker syndrome chromosome region. |journal=Genome Res. |volume=6 |issue= 8 |pages= 735-41 |year= 1997 |pmid= 8858348 |doi= }}
*{{cite journal | vauthors = Han L, Wong D, Dhaka A, Afar D, White M, Xie W, Herschman H, Witte O, Colicelli J | title = Protein binding and signaling properties of RIN1 suggest a unique effector function | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 10 | pages = 4954–9 | year = 1997 | pmid = 9144171 | pmc = 24612 | doi = 10.1073/pnas.94.10.4954 }}
*{{cite journal | author=Craparo A, Freund R, Gustafson TA |title=14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner. |journal=J. Biol. Chem. |volume=272 |issue= 17 |pages= 11663-9 |year= 1997 |pmid= 9111084 |doi= }}
*{{cite journal | vauthors = Ogihara T, Isobe T, Ichimura T, Taoka M, Funaki M, Sakoda H, Onishi Y, Inukai K, Anai M, Fukushima Y, Kikuchi M, Yazaki Y, Oka Y, Asano T | title = 14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain | journal = J. Biol. Chem. | volume = 272 | issue = 40 | pages = 25267–74 | year = 1997 | pmid = 9312143 | doi = 10.1074/jbc.272.40.25267 }}
*{{cite journal | author=Han L, Wong D, Dhaka A, ''et al.'' |title=Protein binding and signaling properties of RIN1 suggest a unique effector function. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 10 |pages= 4954-9 |year= 1997 |pmid= 9144171 |doi= }}
*{{cite journal | vauthors = Hsu SY, Kaipia A, Zhu L, Hsueh AJ | title = Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11 | journal = Mol. Endocrinol. | volume = 11 | issue = 12 | pages = 1858–67 | year = 1997 | pmid = 9369453 | doi = 10.1210/me.11.12.1858 }}
*{{cite journal | author=Ogihara T, Isobe T, Ichimura T, ''et al.'' |title=14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain. |journal=J. Biol. Chem. |volume=272 |issue= 40 |pages= 25267-74 |year= 1997 |pmid= 9312143 |doi= }}
*{{cite journal | vauthors = ((Nagata Ki)), Puls A, Futter C, Aspenstrom P, Schaefer E, Nakata T, Hirokawa N, Hall A | title = The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3 | journal = EMBO J. | volume = 17 | issue = 1 | pages = 149–58 | year = 1998 | pmid = 9427749 | pmc = 1170366 | doi = 10.1093/emboj/17.1.149 }}
*{{cite journal | author=Hsu SY, Kaipia A, Zhu L, Hsueh AJ |title=Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11. |journal=Mol. Endocrinol. |volume=11 |issue= 12 |pages= 1858-67 |year= 1997 |pmid= 9369453 |doi= }}
*{{cite journal | vauthors = Fanger GR, Widmann C, Porter AC, Sather S, Johnson GL, Vaillancourt RR | title = 14-3-3 proteins interact with specific MEK kinases | journal = J. Biol. Chem. | volume = 273 | issue = 6 | pages = 3476–83 | year = 1998 | pmid = 9452471 | doi = 10.1074/jbc.273.6.3476 }}
*{{cite journal | author=Luk SC, Garcia-Barcelo M, Tsui SK, ''et al.'' |title=Assignment of the human 14-3-3 epsilon isoform (YWHAE) to human chromosome 17p13 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=78 |issue= 2 |pages= 105-6 |year= 1997 |pmid= 9371399 |doi= }}
*{{cite journal | vauthors = Ku NO, Liao J, Omary MB | title = Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins | journal = EMBO J. | volume = 17 | issue = 7 | pages = 1892–906 | year = 1998 | pmid = 9524113 | pmc = 1170536 | doi = 10.1093/emboj/17.7.1892 }}
*{{cite journal  | author=Nagata K, Puls A, Futter C, ''et al.'' |title=The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3. |journal=EMBO J. |volume=17 |issue= 1 |pages= 149-58 |year= 1998 |pmid= 9427749 |doi= 10.1093/emboj/17.1.149 }}
*{{cite journal | vauthors = Luk SC, Ngai SM, Tsui SK, Fung KP, Lee CY, Waye MM | title = In vivo and in vitro association of 14-3-3 epsilon isoform with calmodulin: implication for signal transduction and cell proliferation | journal = J. Cell. Biochem. | volume = 73 | issue = 1 | pages = 31–5 | year = 1999 | pmid = 10088721 | doi = 10.1002/(SICI)1097-4644(19990401)73:1<31::AID-JCB4>3.0.CO;2-X }}
*{{cite journal | author=Fanger GR, Widmann C, Porter AC, ''et al.'' |title=14-3-3 proteins interact with specific MEK kinases. |journal=J. Biol. Chem. |volume=273 |issue= 6 |pages= 3476-83 |year= 1998 |pmid= 9452471 |doi= }}
*{{cite journal | vauthors = Ostrerova N, Petrucelli L, Farrer M, Mehta N, Choi P, Hardy J, Wolozin B | author7link=Benjamin Wolozin | title = alpha-Synuclein shares physical and functional homology with 14-3-3 proteins | journal = J. Neurosci. | volume = 19 | issue = 14 | pages = 5782–91 | year = 1999 | pmid = 10407019 | doi =  }}
*{{cite journal | author=Ku NO, Liao J, Omary MB |title=Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins. |journal=EMBO J. |volume=17 |issue= 7 |pages= 1892-906 |year= 1998 |pmid= 9524113 |doi= 10.1093/emboj/17.7.1892 }}
*{{cite journal | vauthors = Finlin BS, Andres DA | title = Phosphorylation-dependent association of the Ras-related GTP-binding protein Rem with 14-3-3 proteins | journal = Arch. Biochem. Biophys. | volume = 368 | issue = 2 | pages = 401–12 | year = 1999 | pmid = 10441394 | doi = 10.1006/abbi.1999.1316 }}
*{{cite journal | author=Luk SC, Ngai SM, Tsui SK, ''et al.'' |title=In vivo and in vitro association of 14-3-3 epsilon isoform with calmodulin: implication for signal transduction and cell proliferation. |journal=J. Cell. Biochem. |volume=73 |issue= 1 |pages= 31-5 |year= 1999 |pmid= 10088721 |doi=  }}
*{{cite journal | vauthors = Dorner C, Ullrich A, Häring HU, Lammers R | title = The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family | journal = J. Biol. Chem. | volume = 274 | issue = 47 | pages = 33654–60 | year = 1999 | pmid = 10559254 | doi = 10.1074/jbc.274.47.33654 }}
*{{cite journal | author=Ostrerova N, Petrucelli L, Farrer M, ''et al.'' |title=alpha-Synuclein shares physical and functional homology with 14-3-3 proteins. |journal=J. Neurosci. |volume=19 |issue= 14 |pages= 5782-91 |year= 1999 |pmid= 10407019 |doi= }}
*{{cite journal | vauthors = Aoki H, Hayashi J, Moriyama M, Arakawa Y, Hino O | title = Hepatitis C Virus Core Protein Interacts with 14-3-3 Protein and Activates the Kinase Raf-1 | journal = J. Virol. | volume = 74 | issue = 4 | pages = 1736–41 | year = 2000 | pmid = 10644344 | pmc = 111649 | doi = 10.1128/JVI.74.4.1736-1741.2000 }}
*{{cite journal | author=Finlin BS, Andres DA |title=Phosphorylation-dependent association of the Ras-related GTP-binding protein Rem with 14-3-3 proteins. |journal=Arch. Biochem. Biophys. |volume=368 |issue= 2 |pages= 401-12 |year= 1999 |pmid= 10441394 |doi= 10.1006/abbi.1999.1316 }}
*{{cite journal | author=Dorner C, Ullrich A, Häring HU, Lammers R |title=The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family. |journal=J. Biol. Chem. |volume=274 |issue= 47 |pages= 33654-60 |year= 1999 |pmid= 10559254 |doi= }}
*{{cite journal  | author=Aoki H, Hayashi J, Moriyama M, ''et al.'' |title=Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. |journal=J. Virol. |volume=74 |issue= 4 |pages= 1736-41 |year= 2000 |pmid= 10644344 |doi=  }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=7531}}
 
{{Adaptor proteins}}
{{Adaptor proteins}}
{{WikiDoc Sources}}
 
[[Category:14-3-3 proteins]]

Latest revision as of 21:49, 4 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

14-3-3 protein epsilon is a protein that in humans is encoded by the YWHAE gene.[1]

Function

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer.[2]

Interactions

YWHAE has been shown to interact with:

See also

References

  1. ↑ Luk SC, Garcia-Barcelo M, Tsui SK, Fung KP, Lee CY, Waye MM (December 1997). "Assignment of the human 14-3-3 epsilon isoform (YWHAE) to human chromosome 17p13 by in situ hybridization". Cytogenet Cell Genet. 78 (2): 105–6. doi:10.1159/000134638. PMID 9371399.
  2. ↑ "Entrez Gene: YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide".
  3. ↑ 3.0 3.1 Conklin DS, Galaktionov K, Beach D (August 1995). "14-3-3 proteins associate with cdc25 phosphatases". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7892–6. doi:10.1073/pnas.92.17.7892. PMC 41252. PMID 7644510.
  4. ↑ Vincenz C, Dixit VM (August 1996). "14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules". J. Biol. Chem. 271 (33): 20029–34. doi:10.1074/jbc.271.33.20029. PMID 8702721.
  5. ↑ Mils V, Baldin V, Goubin F, Pinta I, Papin C, Waye M, Eychene A, Ducommun B (March 2000). "Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase". Oncogene. 19 (10): 1257–65. doi:10.1038/sj.onc.1203419. PMID 10713667.
  6. ↑ Miska EA, Langley E, Wolf D, Karlsson C, Pines J, Kouzarides T (August 2001). "Differential localization of HDAC4 orchestrates muscle differentiation". Nucleic Acids Res. 29 (16): 3439–47. doi:10.1093/nar/29.16.3439. PMC 55849. PMID 11504882.
  7. ↑ Grozinger CM, Schreiber SL (July 2000). "Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization". Proc. Natl. Acad. Sci. U.S.A. 97 (14): 7835–40. doi:10.1073/pnas.140199597. PMC 16631. PMID 10869435.
  8. ↑ Kagan A, Melman YF, Krumerman A, McDonald TV (April 2002). "14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity". EMBO J. 21 (8): 1889–98. doi:10.1093/emboj/21.8.1889. PMC 125975. PMID 11953308.
  9. ↑ 9.0 9.1 Craparo A, Freund R, Gustafson TA (April 1997). "14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner". J. Biol. Chem. 272 (17): 11663–9. doi:10.1074/jbc.272.17.11663. PMID 9111084.
  10. ↑ Fanger GR, Widmann C, Porter AC, Sather S, Johnson GL, Vaillancourt RR (February 1998). "14-3-3 proteins interact with specific MEK kinases". J. Biol. Chem. 273 (6): 3476–83. doi:10.1074/jbc.273.6.3476. PMID 9452471.
  11. ↑ Toyo-oka K, Shionoya A, Gambello MJ, Cardoso C, Leventer R, Ward HL, Ayala R, Tsai LH, Dobyns W, Ledbetter D, Hirotsune S, Wynshaw-Boris A (July 2003). "14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome". Nat. Genet. 34 (3): 274–85. doi:10.1038/ng1169. PMID 12796778.
  12. ↑ Kimura MT, Irie S, Shoji-Hoshino S, Mukai J, Nadano D, Oshimura M, Sato TA (May 2001). "14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction". J. Biol. Chem. 276 (20): 17291–300. doi:10.1074/jbc.M005453200. PMID 11278287.
  13. ↑ McGonigle S, Beall MJ, Feeney EL, Pearce EJ (February 2001). "Conserved role for 14-3-3epsilon downstream of type I TGFbeta receptors". FEBS Lett. 490 (1–2): 65–9. doi:10.1016/S0014-5793(01)02133-0. PMID 11172812.

Further reading

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