VIPoma overview: Difference between revisions
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Revision as of 14:34, 30 August 2015
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VIPoma Microchapters |
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VIPoma overview On the Web |
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American Roentgen Ray Society Images of VIPoma overview |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
A VIPoma (also known as Verner Morrison syndrome, after the physicians who first described it [1]) is a rare (1 per 10,000,000 per year) endocrine tumor, usually (about 90%) originating in the pancreas, which produces vasoactive intestinal peptide (VIP).
It is a syndrome caused by non-β islet-cell tumors. It may be associated with multiple endocrine neoplasia.
The massive amounts of VIP in turn cause profound and chronic watery diarrhea and resultant dehydration, hypokalemia, achlorhydria (hence WDHA-syndrome, or pancreatic cholera syndrome), acidosis, vasodilation (flushing and hypotension), hypercalcemia and hyperglycemia.[2]