POEMS syndrome pathophysiology: Difference between revisions
Created page with "__NOTOC__ {{POEMS syndrome}} {{CMG}} ==Overview== ==Pathophysiology== While the main features of the disease have been described, the exact mechanism of the disease has rema..." |
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While the main features of the disease have been described, the exact mechanism of the disease has remained elusive. The paraprotein alone is insufficient to explain the multi-organ features, and various [[cytokine]]s produced by plasmacytoma cells have therefore been linked with the features of POEMS syndrome, specifically [[IL1B|interleukin 1β]], [[interleukin 6]] and [[TNFα]]. There also seems to be a role of [[vascular endothelial growth factor]], given the [[angiogenesis|angiogenetic]] changes in many tissues. | While the main features of the disease have been described, the exact mechanism of the disease has remained elusive. The paraprotein alone is insufficient to explain the multi-organ features, and various [[cytokine]]s produced by plasmacytoma cells have therefore been linked with the features of POEMS syndrome, specifically [[IL1B|interleukin 1β]], [[interleukin 6]] and [[TNFα]]. There also seems to be a role of [[vascular endothelial growth factor]], given the [[angiogenesis|angiogenetic]] changes in many tissues. | ||
==References== | ==References== | ||
Revision as of 19:51, 19 September 2012
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POEMS syndrome Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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POEMS syndrome pathophysiology On the Web |
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American Roentgen Ray Society Images of POEMS syndrome pathophysiology |
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Risk calculators and risk factors for POEMS syndrome pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
While the main features of the disease have been described, the exact mechanism of the disease has remained elusive. The paraprotein alone is insufficient to explain the multi-organ features, and various cytokines produced by plasmacytoma cells have therefore been linked with the features of POEMS syndrome, specifically interleukin 1β, interleukin 6 and TNFα. There also seems to be a role of vascular endothelial growth factor, given the angiogenetic changes in many tissues.