POEMS syndrome pathophysiology: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
While the main features of the disease have been described, the exact mechanism of the disease has remained elusive. The paraprotein alone is insufficient to explain the multi-organ features, and various [[cytokine]]s produced by plasmacytoma cells have therefore been linked with the features of POEMS syndrome, specifically [[IL1B|interleukin 1β]], [[interleukin 6]] and [[TNFα]]. There also seems to be a role of [[vascular endothelial growth factor]], given the [[angiogenesis|angiogenetic]] changes in many tissues. | While the main features of the disease have been described, the exact mechanism of the disease has remained elusive. The paraprotein alone is insufficient to explain the multi-organ features, and various [[cytokine]]s produced by plasmacytoma cells have therefore been linked with the features of POEMS syndrome, specifically [[IL1B|interleukin 1β]], [[interleukin 6]] and [[TNFα]]. There also seems to be a role of [[vascular endothelial growth factor]], given the [[angiogenesis|angiogenetic]] changes in many tissues. | ||
===Associated Disorders=== | |||
Possible associations included [[pulmonary hypertension]], restrictive lung disease, a [[thrombophilia|thrombotic diathesis]], [[arthralgia]], [[cardiomyopathy]] (systolic dysfunction), [[fever]], low [[vitamin B12]] levels and [[diarrhea]]. | |||
==References== | ==References== | ||
Revision as of 20:11, 19 September 2012
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Risk calculators and risk factors for POEMS syndrome pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
While the main features of the disease have been described, the exact mechanism of the disease has remained elusive. The paraprotein alone is insufficient to explain the multi-organ features, and various cytokines produced by plasmacytoma cells have therefore been linked with the features of POEMS syndrome, specifically interleukin 1β, interleukin 6 and TNFα. There also seems to be a role of vascular endothelial growth factor, given the angiogenetic changes in many tissues.
Associated Disorders
Possible associations included pulmonary hypertension, restrictive lung disease, a thrombotic diathesis, arthralgia, cardiomyopathy (systolic dysfunction), fever, low vitamin B12 levels and diarrhea.