POEMS syndrome diagnostic criteria: Difference between revisions
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Created page with "__NOTOC__ {{POEMS syndrome}} {{CMG}} ==Overview== ==Diagnostic Criteria== A 2003 study<ref name=Dispenzieri>Dispenzieri A, Kyle RA, Lacy MQ, Rajkumar SV, Therneau TM, Larson..." |
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==Diagnostic Criteria== | ==Diagnostic Criteria== | ||
The most recent criteria for the diagnosis of POEMS syndrome<ref name="Disp07"/> require that all of the following be present: | |||
* [[Polyneuropathy]] | |||
* A monoclonal plasma-cell proliferative disorder | |||
* | |||
* | * One or more of the following major criteria: | ||
** Sclerotic bone lesions | ** Sclerotic bone lesions | ||
** Castleman disease | ** [[Castleman's disease]] | ||
** [[ | ** Elevated [[VEGF]] levels | ||
** | |||
** Endocrinopathy (adrenal | * One or more of the following minor criteria: | ||
** Skin changes | ** Organomegaly (enlarged spleen, liver or lymph nodes) | ||
** Extravascular volume overload (oedema, pleural effusion or ascites) | |||
** Endocrinopathy (adrenal, pituitary, gonadal, parathyroid); diabetes or hypothyroidism alone are insufficient | |||
** Skin changes | |||
** [[Papilloedema]] | |||
** [[Thrombocytosis]] or [[polycythaemia]] | |||
In addition, their study showed a number of associations, the relevance of which to diagnosis was unclear: [[clubbing]], [[weight loss]], [[thrombocytosis]], [[polycythemia]] and [[hyperhidrosis]]. Possible associations included [[pulmonary hypertension]], restrictive lung disease, a [[thrombophilia|thrombotic diathesis]], [[arthralgia]], [[cardiomyopathy]] (systolic dysfunction), [[fever]], low [[vitamin B12]] levels and [[diarrhea]]. | In addition, their study showed a number of associations, the relevance of which to diagnosis was unclear: [[clubbing]], [[weight loss]], [[thrombocytosis]], [[polycythemia]] and [[hyperhidrosis]]. Possible associations included [[pulmonary hypertension]], restrictive lung disease, a [[thrombophilia|thrombotic diathesis]], [[arthralgia]], [[cardiomyopathy]] (systolic dysfunction), [[fever]], low [[vitamin B12]] levels and [[diarrhea]]. | ||
Revision as of 19:58, 19 September 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Diagnostic Criteria
The most recent criteria for the diagnosis of POEMS syndrome[1] require that all of the following be present:
- Polyneuropathy
- A monoclonal plasma-cell proliferative disorder
- One or more of the following major criteria:
- Sclerotic bone lesions
- Castleman's disease
- Elevated VEGF levels
- One or more of the following minor criteria:
- Organomegaly (enlarged spleen, liver or lymph nodes)
- Extravascular volume overload (oedema, pleural effusion or ascites)
- Endocrinopathy (adrenal, pituitary, gonadal, parathyroid); diabetes or hypothyroidism alone are insufficient
- Skin changes
- Papilloedema
- Thrombocytosis or polycythaemia
In addition, their study showed a number of associations, the relevance of which to diagnosis was unclear: clubbing, weight loss, thrombocytosis, polycythemia and hyperhidrosis. Possible associations included pulmonary hypertension, restrictive lung disease, a thrombotic diathesis, arthralgia, cardiomyopathy (systolic dysfunction), fever, low vitamin B12 levels and diarrhea.
References
- ↑ Invalid
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