Monoclonal gammopathy of undetermined significance causes: Difference between revisions
Created page with "__NOTOC__ {{ Monoclonal gammopathy of undetermined significance }} Please help WikiDoc by adding content here. It's easy! Click here to learn a..." |
|||
| Line 3: | Line 3: | ||
Please help WikiDoc by adding content here. It's easy! Click [[Help:How_to_Edit_a_Page|here]] to learn about editing. | Please help WikiDoc by adding content here. It's easy! Click [[Help:How_to_Edit_a_Page|here]] to learn about editing. | ||
== | == Causes[edit | edit source] == | ||
{{ | [[Monoclonal gammopathy of undetermined significance]] (MGUS) may be classified according to cytogenetic differences into the following subtypes/groups:<ref name="pmid20884827">{{cite journal |vauthors=Rajkumar SV, Kyle RA, Buadi FK |title=Advances in the diagnosis, classification, risk stratification, and management of monoclonal gammopathy of undetermined significance: implications for recategorizing disease entities in the presence of evolving scientific evidence |journal=Mayo Clin. Proc. |volume=85 |issue=10 |pages=945–8 |date=October 2010 |pmid=20884827 |pmc=2947967 |doi=10.4065/mcp.2010.0520 |url=}}</ref> | ||
{| class="wikitable" | |||
|Abnormalities in cytogenes | |||
|Affected genes | |||
|- | |||
|'''IgH translocation:''' | |||
| | |||
|- | |||
|t(11;14), q(13;32) | |||
|[[cyclin D1]] | |||
|- | |||
|t(4;14)(p16;q32) | |||
|FGFR-3, and MMSET | |||
|- | |||
|t(14;16)(q32;q23) | |||
|C-MAF | |||
|- | |||
|t(6;14)(q32;q11) | |||
|MAFB | |||
|- | |||
|'''IgH non-translocated :''' | |||
| | |||
|- | |||
|Hyper diploid | |||
|Numerous | |||
|} | |||
'''If the staging system involves specific and characteristic findings and features:''' | |||
There is no established system for the staging of [[Monoclonal gammopathy of undetermined significance]] (MGUS). | |||
[[ | |||
Revision as of 14:11, 7 August 2018
|
Monoclonal gammopathy of undetermined significance Microchapters |
|
Differentiating Monoclonal gammopathy of undetermined significance from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Monoclonal gammopathy of undetermined significance causes On the Web |
|
American Roentgen Ray Society Images of Monoclonal gammopathy of undetermined significance causes |
|
FDA on Monoclonal gammopathy of undetermined significance causes |
|
on Monoclonal gammopathy of undetermined significance causes |
|
Monoclonal gammopathy of undetermined significance causes in the news |
|
Blogs on Monoclonal gammopathy of undetermined significance causes |
|
Directions to Hospitals Treating Monoclonal gammopathy of undetermined significance |
|
Risk calculators and risk factors for Monoclonal gammopathy of undetermined significance causes |
Please help WikiDoc by adding content here. It's easy! Click here to learn about editing.
Causes[edit | edit source]
Monoclonal gammopathy of undetermined significance (MGUS) may be classified according to cytogenetic differences into the following subtypes/groups:[1]
| Abnormalities in cytogenes | Affected genes |
| IgH translocation: | |
| t(11;14), q(13;32) | cyclin D1 |
| t(4;14)(p16;q32) | FGFR-3, and MMSET |
| t(14;16)(q32;q23) | C-MAF |
| t(6;14)(q32;q11) | MAFB |
| IgH non-translocated : | |
| Hyper diploid | Numerous |
If the staging system involves specific and characteristic findings and features:
There is no established system for the staging of Monoclonal gammopathy of undetermined significance (MGUS).
- ↑ Rajkumar SV, Kyle RA, Buadi FK (October 2010). "Advances in the diagnosis, classification, risk stratification, and management of monoclonal gammopathy of undetermined significance: implications for recategorizing disease entities in the presence of evolving scientific evidence". Mayo Clin. Proc. 85 (10): 945–8. doi:10.4065/mcp.2010.0520. PMC 2947967. PMID 20884827.