Aplastic anemia pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
[[Aplastic anemia]] is a fatal disorder in which bone marrow's myeloid progenitor cells and [[stem cell]]s are severely decreased or absent. This may be seen because of either an intrinsic defect of the stem cells or immune-mediated stem cell destruction. As a result of hypocellular stem cells, transfusion-dependent anemia, [[thrombocytopenia]], and severe [[neutropenia]] are seen with [[aplastic anemia]]. | [[Aplastic anemia]] is a fatal disorder in which bone marrow's myeloid progenitor cells and [[stem cell]]s are severely decreased or absent. This may be seen because of either an intrinsic defect of the stem cells or immune-mediated stem cell destruction. As a result of hypocellular stem cells, transfusion-dependent anemia, [[thrombocytopenia]], and severe [[neutropenia]] are seen with [[aplastic anemia]]. [[Interferon]]-activated T lymphocytes are involved in [[autoimmune]] destruction of [[stem cell]]s in a significant proportion of patients with the idiopathic or the acquired form of the disease. Due to this, immunosuppressive therapy is effective in some patients. | ||
==References== | ==References== | ||
Revision as of 12:56, 23 September 2012
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Aplastic anemia Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Aplastic anemia pathophysiology On the Web |
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American Roentgen Ray Society Images of Aplastic anemia pathophysiology |
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Risk calculators and risk factors for Aplastic anemia pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Aplastic anemia is a fatal disorder in which bone marrow's myeloid progenitor cells and stem cells are severely decreased or absent. This may be seen because of either an intrinsic defect of the stem cells or immune-mediated stem cell destruction. As a result of hypocellular stem cells, transfusion-dependent anemia, thrombocytopenia, and severe neutropenia are seen with aplastic anemia. Interferon-activated T lymphocytes are involved in autoimmune destruction of stem cells in a significant proportion of patients with the idiopathic or the acquired form of the disease. Due to this, immunosuppressive therapy is effective in some patients.