Aplastic anemia laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
Patients with [[aplastic anemia]] have a hypoplastic bone marrow (<20% cellularity), [[pancytopenia]] (transfusion-dependent anemia, [[thrombocytopenia]], and severe [[neutropenia]]), a low [[reticulocyte count]], and with normal maturation of all cell lines. In approximately 50% of cases of aplastic anemia, there is no obvious cause; chemicals, drugs, viral infections, collagen vascular diseases, and thymoma can be implicated in the remaining cases | Patients with [[aplastic anemia]] have a hypoplastic bone marrow (<20% cellularity), [[pancytopenia]] (transfusion-dependent anemia, [[thrombocytopenia]], and severe [[neutropenia]]), a low [[reticulocyte count]], and with normal maturation of all cell lines. In approximately 50% of cases of aplastic anemia, there is no obvious cause; chemicals, drugs, viral infections, collagen vascular diseases, and thymoma can be implicated in the remaining cases. Initial management involves withdrawal of any potentially causative agents and a CT scan of the chest to rule out an associated thymoma. | ||
==Laboratory Findings== | ==Laboratory Findings== |
Revision as of 12:55, 23 September 2012
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Editor-In-Chief: Aric Hall, M.D., Beth Israel Deaconess Medical Center, Boston, MA [1]
Overview
Patients with aplastic anemia have a hypoplastic bone marrow (<20% cellularity), pancytopenia (transfusion-dependent anemia, thrombocytopenia, and severe neutropenia), a low reticulocyte count, and with normal maturation of all cell lines. In approximately 50% of cases of aplastic anemia, there is no obvious cause; chemicals, drugs, viral infections, collagen vascular diseases, and thymoma can be implicated in the remaining cases. Initial management involves withdrawal of any potentially causative agents and a CT scan of the chest to rule out an associated thymoma.
Laboratory Findings
Electrolyte and Biomarker Studies
- Full blood count
- Renal function
- Electrolytes
- Liver enzymes
- Thyroid function tests
- vitamin B12 and folic acid levels.