Aplastic anemia medical therapy: Difference between revisions
(/* Diagnosis and management of aplastic anemia {{cite journal| author=Marsh JC, Ball SE, Cavenagh J, Darbyshire P, Dokal I, Gordon-Smith EC et al.| title=Guidelines for the diagnosis and management of aplastic anaemia. | journal=Br J Haematol | ye...) |
(/* Diagnosis and management of aplastic anemia {{cite journal| author=Marsh JC, Ball SE, Cavenagh J, Darbyshire P, Dokal I, Gordon-Smith EC et al.| title=Guidelines for the diagnosis and management of aplastic anaemia. | journal=Br J Haematol | ye...) |
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==Overview== | ==Overview== | ||
== | ==Supportive Care in treatment of aplastic anemia <ref name="pmid19673883">{{cite journal| author=Marsh JC, Ball SE, Cavenagh J, Darbyshire P, Dokal I, Gordon-Smith EC et al.| title=Guidelines for the diagnosis and management of aplastic anaemia. | journal=Br J Haematol | year= 2009 | volume= 147 | issue= 1 | pages= 43-70 | pmid=19673883 | doi=10.1111/j.1365-2141.2009.07842.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19673883 }} </ref> (DONOT EDIT)== | ||
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=== | ===Supportive Care=== | ||
Prophylactic platelet transfusions | Prophylactic platelet transfusions | ||
Revision as of 14:32, 23 September 2012
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Aplastic anemia Microchapters |
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Diagnosis |
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Treatment |
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Risk calculators and risk factors for Aplastic anemia medical therapy |
Editor-In-Chief: Aric Hall, M.D., Beth Israel Deaconess Medical Center, Boston, MA [1]
Overview
Supportive Care in treatment of aplastic anemia [1] (DONOT EDIT)
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Supportive CareProphylactic platelet transfusions Irradiated blood products, if indicated Irradiated granulocyte transfusions, if indicated Short course of granulocyte colony-stimulating factor (G-CSF) Prophylactic antibiotic and antifungal drugs Iron chelation therapy, if indicated
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Medical Therapy
In the past, before the above treatments became available, patients with low leukocyte counts were often confined to a sterile room or bubble (to reduce risk of infections), as in the famed case of Ted DeVita.
Pharmacotherapy
Medical therapy of aplastic anemia often includes a short course of anti-thymocyte globulin (ATG or anti-lymphocyte globulin) and several months of treatment with cyclosporin to modulate the immune system. Mild chemotherapy with agents such as cyclophosphamide and vincristine may also be effective. Antibodies therapy, such as ATG, targets T-cells, which are believed to attack the bone marrow. Steroids are generally ineffective.
References
- ↑ Marsh JC, Ball SE, Cavenagh J, Darbyshire P, Dokal I, Gordon-Smith EC; et al. (2009). "Guidelines for the diagnosis and management of aplastic anaemia". Br J Haematol. 147 (1): 43–70. doi:10.1111/j.1365-2141.2009.07842.x. PMID 19673883.