Aplastic anemia medical therapy: Difference between revisions
Jump to navigation
Jump to search
/* Supportive Care in treatment of aplastic anemia {{cite journal| author=Marsh JC, Ball SE, Cavenagh J, Darbyshire P, Dokal I, Gordon-Smith EC et al.| title=Guidelines for the diagnosis and management of aplastic anaemia. | journal=Br J Haematol ... |
No edit summary |
||
| Line 9: | Line 9: | ||
{{cquote| | {{cquote| | ||
===Supportive Care=== | ===Supportive Care=== | ||
* Prophylactic platelet transfusions should be given when the platelet count is <10 x 109/L (or <20 x 109/L in the presence of fever). | * Prophylactic platelet transfusions should be given when the platelet count is <10 x 109/L (or <20 x 109/L in the presence of fever). | ||
| Line 19: | Line 18: | ||
* Systemic antifungal therapy should be introduced into the febrile neutropenia regimen early if fevers persist. | * Systemic antifungal therapy should be introduced into the febrile neutropenia regimen early if fevers persist. | ||
* Iron chelation therapy should be considered when the serum ferritin is >1000 µg/L. | * Iron chelation therapy should be considered when the serum ferritin is >1000 µg/L. | ||
}} | }} | ||
==Definitive treatment of aplastic anemia <ref name="pmid19673883">{{cite journal| author=Marsh JC, Ball SE, Cavenagh J, Darbyshire P, Dokal I, Gordon-Smith EC et al.| title=Guidelines for the diagnosis and management of aplastic anaemia. | journal=Br J Haematol | year= 2009 | volume= 147 | issue= 1 | pages= 43-70 | pmid=19673883 | doi=10.1111/j.1365-2141.2009.07842.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19673883 }} </ref> (DONOT EDIT)== | ==Definitive treatment of aplastic anemia <ref name="pmid19673883">{{cite journal| author=Marsh JC, Ball SE, Cavenagh J, Darbyshire P, Dokal I, Gordon-Smith EC et al.| title=Guidelines for the diagnosis and management of aplastic anaemia. | journal=Br J Haematol | year= 2009 | volume= 147 | issue= 1 | pages= 43-70 | pmid=19673883 | doi=10.1111/j.1365-2141.2009.07842.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19673883 }} </ref> (DONOT EDIT)== | ||
{{cquote| | {{cquote| | ||
===Definitive Treatment=== | ===Definitive Treatment=== | ||
Revision as of 14:55, 23 September 2012
|
Aplastic anemia Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Aplastic anemia medical therapy On the Web |
|
American Roentgen Ray Society Images of Aplastic anemia medical therapy |
|
Risk calculators and risk factors for Aplastic anemia medical therapy |
Editor-In-Chief: Aric Hall, M.D., Beth Israel Deaconess Medical Center, Boston, MA [1]
Overview
Medical therapy of aplastic anemia often includes a short course of anti-thymocyte globulin (ATG or anti-lymphocyte globulin) and several months of treatment with cyclosporin to modulate the immune system. Mild chemotherapy with agents such as cyclophosphamide and vincristine may also be effective. Antibodies therapy, such as ATG, targets T-cells, which are believed to attack the bone marrow. Steroids are generally ineffective.
Medical Therapy
Supportive Care in treatment of aplastic anemia [1] (DONOT EDIT)
| “ |
Supportive Care
|
” |
Definitive treatment of aplastic anemia [1] (DONOT EDIT)
{{cquote|
Definitive Treatment
- Infection or uncontrolled bleeding should be treated first before giving [[immunosuppressive] therapy
- Allogeneic bone marrow transplantation (BMT) from a human leucocyte antigen (HLA)-identical sibling donor
- Immunosuppressive therapy with the standard regimen of antithymocyte globulin (ATG) and ciclosporin
- Matched unrelated donor bone marrow transplantation (MUD BMT), if indicated
- Maintain safe platelet count and haemoglobin level with transfusions during pregnancy and consider ciclosporin
Use of haemopoietic growth factors (such as recombinant human erythropoietin [rHuEPO] or G-CSF) and prednisolone were considered but not recommended.
}}
References
- ↑ 1.0 1.1 Marsh JC, Ball SE, Cavenagh J, Darbyshire P, Dokal I, Gordon-Smith EC; et al. (2009). "Guidelines for the diagnosis and management of aplastic anaemia". Br J Haematol. 147 (1): 43–70. doi:10.1111/j.1365-2141.2009.07842.x. PMID 19673883.