Aplastic anemia medical therapy: Difference between revisions
(/* Specific Treatment of Aplastic Anaemia: Management of Aplastic Anaemia in the Presence of an Abnormal Cytogenetic Clone {{cite journal| author=Marsh JC, Ball SE, Cavenagh J, Darbyshire P, Dokal I, Gordon-Smith EC et al.| title=Guidelines for th...) |
(/* Specific Treatment of Aplastic Anaemia: Management of Aplastic Anaemia in the Presence of an Abnormal Cytogenetic Clone {{cite journal| author=Marsh JC, Ball SE, Cavenagh J, Darbyshire P, Dokal I, Gordon-Smith EC et al.| title=Guidelines for th...) |
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* The presence of an abnormal cytogenetic clone in the presence of an otherwise typical aplastic anaemia does not necessarily equate with a diagnosis of [[myelodysplastic syndromes]] (MDS) or [[acute myeloid leukaemia]] (AML), as abnormal cytogenetic clones occur in up to 12% of patients with [[aplastic anaemia]]. | * The presence of an abnormal cytogenetic clone in the presence of an otherwise typical aplastic anaemia does not necessarily equate with a diagnosis of [[myelodysplastic syndromes]] (MDS) or [[acute myeloid leukaemia]] (AML), as abnormal cytogenetic clones occur in up to 12% of patients with [[aplastic anaemia]]. | ||
* The presence of monosomy 7 is more often sinister with a high risk of transformation to MDS or AML. | * The presence of monosomy 7 is more often sinister with a high risk of transformation to MDS or AML. | ||
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==Specific Treatment of Aplastic Anaemia: Management of Aplastic Anaemia in the Presence of an Abnormal Cytogenetic Clone <ref name="pmid19673883">{{cite journal| author=Marsh JC, Ball SE, Cavenagh J, Darbyshire P, Dokal I, Gordon-Smith EC et al.| title=Guidelines for the diagnosis and management of aplastic anaemia. | journal=Br J Haematol | year= 2009 | volume= 147 | issue= 1 | pages= 43-70 | pmid=19673883 | doi=10.1111/j.1365-2141.2009.07842.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19673883 }} </ref> (DONOT EDIT)== | |||
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===Management of Aplastic Anaemia in the Presence of an Abnormal Cytogenetic Clone=== | |||
* Management of Patients with [[Aplastic Anaemia]] Who Have a Significant PNH Clone, Resulting in Clinical and/or Laboratory Evidence of Haemolysis | |||
* Small PNH clones, in the absence of evidence of [[haemolysis]], occur in up to 50% of patients with [[aplastic anaemia]]. | |||
* ATG is not recommended if there is a history of PNH-associated [[thrombosis]]. | |||
* All patients who are not transplanted should be screened for PNH by flow cytometry every 12 months. | |||
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Revision as of 16:08, 23 September 2012
Aplastic anemia Microchapters |
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Editor-In-Chief: Aric Hall, M.D., Beth Israel Deaconess Medical Center, Boston, MA [1]
Overview
Medical therapy of aplastic anemia often includes a short course of anti-thymocyte globulin (ATG or anti-lymphocyte globulin) and several months of treatment with cyclosporin to modulate the immune system. Mild chemotherapy with agents such as cyclophosphamide and vincristine may also be effective. Antibodies therapy, such as ATG, targets T-cells, which are believed to attack the bone marrow. Steroids are generally ineffective.
Medical Therapy
Supportive Care in treatment of aplastic anemia [1] (DONOT EDIT)
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Supportive Care
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Specific Treatment of Aplastic Anaemia: General Comments [1] (DONOT EDIT)
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General Comments
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Specific Treatment of Aplastic Anaemia: Human Leucocyte Antigen (HLA)-identical Sibling Donor Transplantation [1] (DONOT EDIT)
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Human Leucocyte Antigen (HLA)-identical Sibling Donor Transplantation
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Specific Treatment of Aplastic Anaemia: Immunosuppressive Therapy: ATG and Ciclosporin [1] (DONOT EDIT)
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Immunosuppressive Therapy: ATG and Ciclosporin
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Specific Treatment of Aplastic Anaemia: Trial Therapy or Clinical Research Protocols [1] (DONOT EDIT)
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Trial Therapy or Clinical Research Protocols
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Specific Treatment of Aplastic Anaemia: Management of Aplastic Anaemia in the Presence of an Abnormal Cytogenetic Clone [1] (DONOT EDIT)
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Management of Aplastic Anaemia in the Presence of an Abnormal Cytogenetic Clone
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Specific Treatment of Aplastic Anaemia: Management of Aplastic Anaemia in the Presence of an Abnormal Cytogenetic Clone [1] (DONOT EDIT)
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Management of Aplastic Anaemia in the Presence of an Abnormal Cytogenetic Clone
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Specific Treatment of Aplastic Anaemia: Management of Aplastic Anaemia in the Presence of an Abnormal Cytogenetic Clone [1] (DONOT EDIT)
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Management of Aplastic Anaemia in the Presence of an Abnormal Cytogenetic Clone
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