Aplastic anemia laboratory findings: Difference between revisions
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==Laboratory Findings== | ==Laboratory Findings== | ||
===Complete Blood Count=== | ===Complete Blood Count=== | ||
* Decreased [[hemoglobin]] | |||
* Decreased [[hematocrit]] | |||
* Absolute red blood cells, white blood cells, and platelets . | |||
* Mean corpuscular volume | |||
Reticulocyte Count | Reticulocyte Count | ||
* Low reticulocyte levels. | |||
===Bone Marrow Tests (Aspiration and biopsy)=== | ===Bone Marrow Tests (Aspiration and biopsy)=== |
Revision as of 14:15, 24 September 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Patients with aplastic anemia have a hypoplastic bone marrow (<20% cellularity), pancytopenia (transfusion-dependent anemia, thrombocytopenia, and severe neutropenia), a low reticulocyte count, and with normal maturation of all cell lines.
Laboratory Findings
Complete Blood Count
- Decreased hemoglobin
- Decreased hematocrit
- Absolute red blood cells, white blood cells, and platelets .
- Mean corpuscular volume
Reticulocyte Count
- Low reticulocyte levels.
Bone Marrow Tests (Aspiration and biopsy)
- Bone marrow aspiration might be done to find out if and why bone marrow isn't making enough blood cells. For this test, a small amount of bone marrow fluid is aspirated through a needle. The sample is looked at under a microscope to check for faulty cells.
- A bone marrow biopsy might be done at the same time as an aspiration or afterward. For this test, your doctor removes a small amount of bone marrow tissue through a needle. The tissue is checked for the number and types of cells in the bone marrow. In aplastic anemia, the bone marrow has a lower than normal number of all three types of blood cells.
- Bone marrow biopsy (hypoplastic bone marrow (<20% cellularity), and with normal maturation of all cell lines.
- Full blood count (pancytopenia (anemia, thrombocytopenia, and severe neutropenia)
- Peripheral blood smear (normocytic RBC, decreased or absent reticulocytes)
- Renal function
- Electrolytes
- Liver enzymes
- Thyroid function tests
- vitamin B12 and folic acid levels.