Minimal change disease causes: Difference between revisions
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==Overview== | ==Overview== | ||
==Causes== | ==Causes== | ||
Minimal change disease can be associated with food allergies, medications, or hematologic malignancies, or it can occur [[idiopathic|idiopathically]]. The pathology does not appear to involve complement, [[Antibody|immunoglobulins]], or immune complex deposition. Rather, an altered cell-mediated immunologic response with abnormal secretion of [[lymphokine]]s by [[T cell]]s is thought to reduce the production of anions in the [[glomerular basement membrane]], thereby increasing the glomerular permeability to [[serum albumin]] through a reduction of electrostatic repulsion.<ref name=Mathieson_2003>{{cite journal |author=Mathieson P |title=Immune dysregulation in minimal change nephropathy |journal=Nephrol Dial Transplant |volume=18 Suppl 6 |issue= |pages=vi26-9 |year=2003 |pmid=12953038}}</ref> The loss of [[Anion|anionic]] charges is also thought to favor foot process fusion. With minimal change disease the kidney tissue appears normal under a light microscope, but shows [[podocyte]] foot process effacement under an [[Electron microscopy|electron microscope]].<ref name=Robbins_2005 /> | Minimal change disease can be associated with food allergies, medications, or hematologic malignancies, or it can occur [[idiopathic|idiopathically]]. The pathology does not appear to involve complement, [[Antibody|immunoglobulins]], or immune complex deposition. Rather, an altered cell-mediated immunologic response with abnormal secretion of [[lymphokine]]s by [[T cell]]s is thought to reduce the production of anions in the [[glomerular basement membrane]], thereby increasing the glomerular permeability to [[serum albumin]] through a reduction of electrostatic repulsion.<ref name=Mathieson_2003>{{cite journal |author=Mathieson P |title=Immune dysregulation in minimal change nephropathy |journal=Nephrol Dial Transplant |volume=18 Suppl 6 |issue= |pages=vi26-9 |year=2003 |pmid=12953038}}</ref> The loss of [[Anion|anionic]] charges is also thought to favor foot process fusion. With minimal change disease the kidney tissue appears normal under a light microscope, but shows [[podocyte]] foot process effacement under an [[Electron microscopy|electron microscope]].<ref name=Robbins_2005>{{cite book | author = Kumar V, Fausto N, Abbas A (editors) | title = Robbins & Cotran Pathologic Basis of Disease | edition = 7th | pages=pp. 981-2 | publisher = Saunders | year = 2003 | id = ISBN 978-0-721-60187-8 }}</ref> | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 14:27, 28 September 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Causes
Minimal change disease can be associated with food allergies, medications, or hematologic malignancies, or it can occur idiopathically. The pathology does not appear to involve complement, immunoglobulins, or immune complex deposition. Rather, an altered cell-mediated immunologic response with abnormal secretion of lymphokines by T cells is thought to reduce the production of anions in the glomerular basement membrane, thereby increasing the glomerular permeability to serum albumin through a reduction of electrostatic repulsion.[1] The loss of anionic charges is also thought to favor foot process fusion. With minimal change disease the kidney tissue appears normal under a light microscope, but shows podocyte foot process effacement under an electron microscope.[2]