Aplastic anemia classification: Difference between revisions
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==Classification== | ==Classification== | ||
=== | Aplastic anemia may be classified according to blood cell counts into 3 subgroups:<ref name="pmid24424170">{{cite journal |vauthors=Dolberg OJ, Levy Y |title=Idiopathic aplastic anemia: diagnosis and classification |journal=Autoimmun Rev |volume=13 |issue=4-5 |pages=569–73 |date=2014 |pmid=24424170 |doi=10.1016/j.autrev.2014.01.014 |url=}}</ref> | ||
=== | ** Moderately severe aplastic anemia or non severe AA (nSAA) | ||
** Severe aplastic anemia (SAA) | |||
** Very severe aplastic anemia(vSAA) | |||
{| class="wikitable" | |||
|+ '''Classification of aplastic anemia (two out of three criteria must be met)''' | |||
! | |||
!nSAA | |||
!SAA | |||
!vSAA | |||
|- | |||
|Reticulocytes | |||
|<20G/L | |||
|<20G/L | |||
|<20G/L | |||
|- | |||
|Platelets | |||
|<50 G / L | |||
|<20G/L | |||
|<20G/L | |||
|- | |||
|Neutrophilic granulocytes | |||
|<1.0 G / L | |||
|<0.5G/L | |||
|0.2G/l | |||
|} | |||
This classification is of prognostic relevance and has an influence on therapeutic procedures. | |||
{| class="wikitable" | |||
|+classification based on the presumed etiology | |||
!''Acquired'' | |||
! | |||
|- | |||
|Idiopathic | |||
| | |||
|- | |||
|Secondry | |||
|Irradiation | |||
Drugs | |||
Idiosyncratic reactions | |||
Viruses | |||
Immune diseases | |||
Pregnancy | |||
PNH | |||
|- | |||
|'''''Inherited''''' | |||
|Fanconis anemia | |||
Dyskeratosis congenital | |||
Amegakaryocytic thrombocytopenia | |||
Shwachman-Diamond syndrome | |||
|} | |||
==References== | ==References== | ||
Revision as of 17:55, 14 August 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.D. [2]
Overview
Aplastic anemia can be classified into mild, moderate, severe, and very severe depending on the severity of cellularity of bone marrow and the blood tests.
Classification
Aplastic anemia may be classified according to blood cell counts into 3 subgroups:[1]
- Moderately severe aplastic anemia or non severe AA (nSAA)
- Severe aplastic anemia (SAA)
- Very severe aplastic anemia(vSAA)
| nSAA | SAA | vSAA | |
|---|---|---|---|
| Reticulocytes | <20G/L | <20G/L | <20G/L |
| Platelets | <50 G / L | <20G/L | <20G/L |
| Neutrophilic granulocytes | <1.0 G / L | <0.5G/L | 0.2G/l |
This classification is of prognostic relevance and has an influence on therapeutic procedures.
| Acquired | |
|---|---|
| Idiopathic | |
| Secondry | Irradiation
Drugs Idiosyncratic reactions Viruses Immune diseases Pregnancy PNH |
| Inherited | Fanconis anemia
Dyskeratosis congenital Amegakaryocytic thrombocytopenia Shwachman-Diamond syndrome |
References
- ↑ Dolberg OJ, Levy Y (2014). "Idiopathic aplastic anemia: diagnosis and classification". Autoimmun Rev. 13 (4–5): 569–73. doi:10.1016/j.autrev.2014.01.014. PMID 24424170.