POEMS syndrome differential diagnosis: Difference between revisions
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{{POEMS syndrome}} | {{POEMS syndrome}} | ||
==Differential diagnosis== | |||
POEMS syndrome must be differentiated from other similar conditions which lead to multiple endocrine disorders such as [[autoimmune polyendocrine syndrome]], Hirata syndrome, [[Kearns–Sayre syndrome]] and [[Wolfram syndrome|Wolfram syndromes]].<ref name="pmid21533467">{{cite journal |vauthors=Sherer Y, Bardayan Y, Shoenfeld Y |title=Thymoma, thymic hyperplasia, thymectomy and autoimmune diseases (Review) |journal=Int. J. Oncol. |volume=10 |issue=5 |pages=939–43 |year=1997 |pmid=21533467 |doi= |url=}}</ref><ref name="Nozza2017">{{cite journal|last1=Nozza|first1=Andrea|title=POEMS SYNDROME: AN UPDATE|journal=Mediterranean Journal of Hematology and Infectious Diseases|volume=9|issue=1|year=2017|pages=e2017051|issn=2035-3006|doi=10.4084/mjhid.2017.051}}</ref><ref name="pmid17342029">{{cite journal |vauthors=Maceluch JA, Niedziela M |title=The clinical diagnosis and molecular genetics of kearns-sayre syndrome: a complex mitochondrial encephalomyopathy |journal=Pediatr Endocrinol Rev |volume=4 |issue=2 |pages=117–37 |year=2006 |pmid=17342029 |doi= |url=}}</ref><ref name="pmid22790102">{{cite journal |vauthors=Rigoli L, Di Bella C |title=Wolfram syndrome 1 and Wolfram syndrome 2 |journal=Curr. Opin. Pediatr. |volume=24 |issue=4 |pages=512–7 |year=2012 |pmid=22790102 |doi=10.1097/MOP.0b013e328354ccdf |url=}}</ref><ref name="HusebyeAnderson2010">{{cite journal|last1=Husebye|first1=Eystein S.|last2=Anderson|first2=Mark S.|title=Autoimmune Polyendocrine Syndromes: Clues to Type 1 Diabetes Pathogenesis|journal=Immunity|volume=32|issue=4|year=2010|pages=479–487|issn=10747613|doi=10.1016/j.immuni.2010.03.016}}</ref> | |||
{| class="wikitable" | |||
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Disease | |||
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Addison's disease | |||
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Type 1 diabetes mellitus | |||
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Hypothyroidism | |||
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Other disorders present | |||
|- | |||
|APS type 1 | |||
|<nowiki>+</nowiki> | |||
|Less common | |||
|Less common | |||
|[[Hypoparathyroidism]]<br>[[Candidiasis]]<br>[[Hypogonadism]] | |||
|- | |||
|APS type 2 | |||
| + | |||
| + | |||
| + | |||
|[[Hypogonadism]]<br>[[Malabsorption]] | |||
|- | |||
|APS type 3 | |||
|<nowiki>-</nowiki> | |||
| + | |||
|<nowiki>+</nowiki> | |||
|[[Malabsorption]] | |||
|- | |||
|[[Thymoma]] | |||
| + | |||
|<nowiki>-</nowiki> | |||
| + | |||
|[[Myasthenia gravis]]<br>[[Cushing syndrome]] | |||
|- | |||
|[[Chromosomal abnormalities]]<br>([[Turner syndrome]],<br>[[Down's syndrome]]) | |||
| - | |||
| + | |||
| + | |||
|[[Cardiac dysfunction ]] | |||
|- | |||
|[[Kearns–Sayre syndrome]] | |||
|<nowiki>-</nowiki> | |||
| + | |||
|<nowiki>-</nowiki> | |||
|[[Myopathy]]<br>[[Hypoparathyroidism]]<br>[[Hypogonadism]] | |||
|- | |||
|[[Wolfram syndrome]] | |||
|<nowiki>-</nowiki> | |||
| + | |||
|<nowiki>-</nowiki> | |||
|[[Diabetes insipidus]]<br>[[Optic atrophy]]<br>[[Deafness]]<br> | |||
|- | |||
|[[POEMS syndrome]] | |||
|<nowiki>-</nowiki> | |||
| + | |||
|<nowiki>-</nowiki> | |||
|[[Polyneuropathy]]<br>[[Hypogonadism]]<br>[[Plasma cell dyscrasia|Plasma cell dyscrasias]] | |||
|} | |||
==References== | ==References== | ||
Revision as of 20:17, 27 October 2017
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Differential diagnosis
POEMS syndrome must be differentiated from other similar conditions which lead to multiple endocrine disorders such as autoimmune polyendocrine syndrome, Hirata syndrome, Kearns–Sayre syndrome and Wolfram syndromes.[1][2][3][4][5]
| Disease | Addison's disease | Type 1 diabetes mellitus | Hypothyroidism | Other disorders present |
|---|---|---|---|---|
| APS type 1 | + | Less common | Less common | Hypoparathyroidism Candidiasis Hypogonadism |
| APS type 2 | + | + | + | Hypogonadism Malabsorption |
| APS type 3 | - | + | + | Malabsorption |
| Thymoma | + | - | + | Myasthenia gravis Cushing syndrome |
| Chromosomal abnormalities (Turner syndrome, Down's syndrome) |
- | + | + | Cardiac dysfunction |
| Kearns–Sayre syndrome | - | + | - | Myopathy Hypoparathyroidism Hypogonadism |
| Wolfram syndrome | - | + | - | Diabetes insipidus Optic atrophy Deafness |
| POEMS syndrome | - | + | - | Polyneuropathy Hypogonadism Plasma cell dyscrasias |
References
- ↑ Sherer Y, Bardayan Y, Shoenfeld Y (1997). "Thymoma, thymic hyperplasia, thymectomy and autoimmune diseases (Review)". Int. J. Oncol. 10 (5): 939–43. PMID 21533467.
- ↑ Nozza, Andrea (2017). "POEMS SYNDROME: AN UPDATE". Mediterranean Journal of Hematology and Infectious Diseases. 9 (1): e2017051. doi:10.4084/mjhid.2017.051. ISSN 2035-3006.
- ↑ Maceluch JA, Niedziela M (2006). "The clinical diagnosis and molecular genetics of kearns-sayre syndrome: a complex mitochondrial encephalomyopathy". Pediatr Endocrinol Rev. 4 (2): 117–37. PMID 17342029.
- ↑ Rigoli L, Di Bella C (2012). "Wolfram syndrome 1 and Wolfram syndrome 2". Curr. Opin. Pediatr. 24 (4): 512–7. doi:10.1097/MOP.0b013e328354ccdf. PMID 22790102.
- ↑ Husebye, Eystein S.; Anderson, Mark S. (2010). "Autoimmune Polyendocrine Syndromes: Clues to Type 1 Diabetes Pathogenesis". Immunity. 32 (4): 479–487. doi:10.1016/j.immuni.2010.03.016. ISSN 1074-7613.