Avian influenza pathophysiology: Difference between revisions

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Revision as of 18:54, 28 January 2013

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Genetic factors in distinguishing between "human flu viruses" and "avian flu viruses" include:

PB2: (RNA polymerase): Amino acid (or residue) position 627 in the PB2 protein encoded by the PB2 RNA gene. Until H5N1, all known avian influenza viruses had a Glu at position 627, while all human influenza viruses had a lysine.
HA: (hemagglutinin): Avian influenza HA bind alpha 2-3 sialic acid receptors while human influenza HA bind alpha 2-6 sialic acid receptors. Swine influenza viruses have the ability to bind both types of sialic acid receptors.

@@ Line 8: / Line 8: @@
 ==Pathophysiology==
 ===Genetics===
-Genetic factors in distinguishing between "[[human flu]] viruses" and "avian flu viruses" include:
+[[Genetic]] factors in distinguishing between "[[human flu]] viruses" and "avian flu [[virus]]es" include:
-:'''PB2''': ([[RNA polymerase]]): [[Amino acid]] (or [[residue]]) position 627 in the PB2 protein encoded by the PB2 [[RNA]] gene. Until [[H5N1]], all known avian influenza viruses had a [[Glutamic acid|Glu]] at position 627, while all human influenza viruses had a [[lysine]].
+*''PB2'': ([[RNA polymerase]]): [[Amino acid]] (or [[residue]]) position 627 in the PB2 [[protein]] encoded by the PB2 [[RNA]] [[gene]]. Until [[H5N1]], all known avian [[influenza virus]]es had a [[Glutamic acid|Glu]] at position 627, while all human [[influenza virus]]es had a [[lysine]].
-:'''HA''': ([[hemagglutinin]]): Avian influenza HA bind alpha 2-3 [[sialic acid]] receptors while human influenza HA bind alpha 2-6 sialic acid receptors. Swine influenza viruses have the ability to bind both types of sialic acid receptors.
+*''HA'': ([[hemagglutinin]]): Avian [[influenza]] HA bind alpha 2-3 [[sialic acid]] receptors while human [[influenza]] HA bind alpha 2-6 [[sialic acid]] [[receptor]]s. [[swine flu|Swine]] [[influenza]] [[virus]]es have the ability to bind both types of [[sialic acid]] [[receptor]]s.
 ==References==