Avian influenza classification: Difference between revisions

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Revision as of 13:09, 23 April 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Yazan Daaboul, M.D.

Overview

Classification

Classification of avian influenza may be based on either the pathogenicity of the virus or the viral genetics (influenza subtypes). To date, only influenza type A has been associated with avian influenza.

=Pathogenecity of the Virus

Avian influenza may be classified based on the pathogenicity of the virus:

Low pathogenic avian influenza (LPAI)

Mild/no clinical manifestations among humans

May convert to highly pathogenic avian influenza

Highly pathogenic avian influenza (HPAI)

Moderate/severe clinical manifestations among humans

Viral subtypes H5 and H7 are associated with HPAI

Subtypes Based on Molecular Viral Genetics

To date, only influenza type A has been associated with avian influenza. Neither influenza B nor influenza C is associated with avian influenza.
Although avian influenza has many subtypes of haemagglutinin (HA) and neuraminidase (NA), only 3 subtypes have been associated with human infections.
The table below lists the subtypes of influenza A that have been associated with avian influenza in humans:

Influenza Subtype	Number of Subtypes	Pathogenicity	Clinical Manifestations
Influenza Subtype	Number of Subtypes	Pathogenicity	Influenza A H5	At least 9	May be either HPAI or LPAI	May cause either mild or severe/fatal clinical manifestations
Influenza A H7	At least 9	May be either HPAI or LPAI	May cause either mild or severe/fatal clinical manifestations
Influenza A H9	At least 9	Only reported as LPAI	Less likely to cause infections in humans

References

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 __NOTOC__
 {{Avian influenza}}
+{{CMG}}; {{AE}} {{YD}}
+==Overview==
+==Classification==
+Classification of avian influenza may be based on either the pathogenicity of the virus or the viral genetics (influenza subtypes). To date, only influenza type A has been associated with avian influenza.
-Please help WikiDoc by adding content here.  It's easy!  Click  [[Help:How_to_Edit_a_Page|here]]  to learn about editing.
+===Pathogenecity of the Virus==
+Avian influenza may be classified based on the pathogenicity of the virus:
+*Low pathogenic avian influenza (LPAI)
+::Mild/no clinical manifestations among humans
+::May convert to highly pathogenic avian influenza
+*Highly pathogenic avian influenza (HPAI)
+::Moderate/severe clinical manifestations among humans
+::Viral subtypes H5 and H7 are associated with HPAI
+===Subtypes Based on Molecular Viral Genetics===
+*To date, only influenza type A has been associated with avian influenza. Neither influenza B nor influenza C is associated with avian influenza.
+*Although avian influenza has many subtypes of haemagglutinin (HA) and neuraminidase (NA), only 3 subtypes have been associated with human infections.
+*The table below lists the subtypes of influenza A that have been associated with avian influenza in humans:
+  {| style="border: 0px; font-size: 90%; margin: 3px;" align=center
+! style="background: #4479BA; padding: 5px 5px;" rowspan=2 | {{fontcolor|#FFFFFF|Influenza Subtype}}
+! style="background: #4479BA; padding: 5px 5px;" rowspan=2 | {{fontcolor|#FFFFFF|Number of Subtypes}}
+! style="background: #4479BA; padding: 5px 5px;" rowspan=2  | {{fontcolor|#FFFFFF|Pathogenicity}}
+! style="background: #4479BA; padding: 5px 5px;" colspan=4 | {{fontcolor|#FFFFFF|Clinical Manifestations}}
+|-
+| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold;" | ''[[Influenza A H5]]''
+| style="padding: 5px 5px; background: #F5F5F5;" | At least 9
+! style="padding: 5px 5px; background: #F5F5F5;" | May be either HPAI or LPAI
+! style="padding: 5px 5px; background: #F5F5F5;" | May cause either mild or severe/fatal clinical manifestations
+|-
+| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold;" | ''[[Influenza A H7]]''
+| style="padding: 5px 5px; background: #F5F5F5;" | At least 9
+! style="padding: 5px 5px; background: #F5F5F5;" | May be either HPAI or LPAI
+! style="padding: 5px 5px; background: #F5F5F5;" | May cause either mild or severe/fatal clinical manifestations
+|-
+| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold;" | ''[[Influenza A H9]]''
+| style="padding: 5px 5px; background: #F5F5F5;" | At least 9
+! style="padding: 5px 5px; background: #F5F5F5;" | Only reported as LPAI
+! style="padding: 5px 5px; background: #F5F5F5;" | Less likely to cause infections in humans
+|}
 ==References==