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| ==Causes== | | ==Causes== |
| === Common Causes=== | | === Common Causes=== |
| Extrapulmonary tuberculosis is the most frequent cause of FUO.<ref name="Harrison">[http://books.mcgraw-hill.com/medical/harrisons/ Harrison's Principles of Internal Medicine] 16th Edition, The McGraw-Hill Companies, ISBN 0-07-140235-7</ref> | | *[[Extrapulmonary tuberculosis]]<ref name="Harrison">[http://books.mcgraw-hill.com/medical/harrisons/ Harrison's Principles of Internal Medicine] 16th Edition, The McGraw-Hill Companies, ISBN 0-07-140235-7</ref> |
| Drug fever, as sole symptom of an adverse reaction to medication, should always be thought of. Disseminated granulomatoses such as [[Tuberculosis]], [[Histoplasmosis]], [[Coccidioidomycosis]], [[Blastomycosis]] and [[Sarcoidosis]] are associated with FUO. | | *[[Drug fever]] |
| | *[[Tuberculosis]] |
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| [[Lymphoma]]s are the most common cause of FUO in adults. Thromboembolic disease (i.e. [[pulmonary embolism]], [[deep venous thrombosis]]) occasionally shows [[fever]]. Although infrequent, its potentially lethal consequences warrant evaluation of this cause. [[Endocarditis]], although uncommon, is another important thing to consider. An underestimated reason is factitious [[fever]]. Patients frequently are women that work, or have worked, in the medical field and have complex [[medical history|medical histories]].<ref name="Mandell"> | | *[[Histoplasmosis]] |
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| | *[[Coccidioidomycosis]] |
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| | *[[Blastomycosis]] |
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| | *[[Sarcoidosis]] |
| | *[[Lymphoma]] |
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| | *[[pulmonary embolism]] |
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| | *[[deep venous thrombosis]]) |
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| | *[[Endocarditis]] |
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| | *Factitious [[fever]]<ref name="Mandell"> |
| [http://www.ppidonline.com/ Mandell's Principles and Practices of Infection Diseases] 6th Edition (2004) by Gerald L. Mandell MD, MACP, John E. Bennett MD, Raphael Dolin MD, ISBN 0-443-06643-4 · Hardback · 4016 Pages Churchill Livingstone </ref> | | [http://www.ppidonline.com/ Mandell's Principles and Practices of Infection Diseases] 6th Edition (2004) by Gerald L. Mandell MD, MACP, John E. Bennett MD, Raphael Dolin MD, ISBN 0-443-06643-4 · Hardback · 4016 Pages Churchill Livingstone </ref> |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Causes
Common Causes
Causes by Organ System
Cardiovascular
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Endocarditis, Deep vein thrombosis, Thrombophlebitis
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Chemical / poisoning
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Bismuth
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Dermatologic
|
No underlying causes
|
Drug Side Effect
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Allopurinol, Amphotericin B, Aminoglutethimide, Barbiturates, Bismuth, Chlorpromazine, Ethotoin, GMCSF, Levomepromazine, Methyldopa, Perazine, Phenophthalein, Pipothiazine, Promazine, Penicillin, Phenytoin, Quinidine, Rifampicin
|
Ear Nose Throat
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Periodic fever aphthous pharyngitis and cervical adenopathy
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Endocrine
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No underlying causes
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Environmental
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No underlying causes
|
Gastroenterologic
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Cirrhosis of liver, Crohn's disease, Ulcerative Colitis, Whipple's disease, Choledochal cyst, Cholangitis
|
Genetic
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No underlying causes
|
Hematologic
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Angioimmunoblastic lymphadenopathy with dysproteinaemia, Hyperimmunoglobulinemia D and periodic fever syndrome
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Iatrogenic
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No underlying causes
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Infectious Disease
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Lung abscess, Subdiaphragmatic abscess, Liver abscess, Pyelonephritis, Salmonella typhi, Osteomyelitis, Gonorrhoea, Leptospirosis, Q fever, Endocarditis, Tularaemia, Scrub typhus, Relapsing fever, Rickettsia akari, Boutonneuse fever, Mycobacterium tuberculosis, Yersinia enterocolitica, Periodic fever aphthous pharyngitis and cervical adenopathy, Ehrlichiosis, Atypical pneumonia, Cyclical neutropenia, Xanthogranulomatous pyelonephritis, Streptococcus suis, Catheter infections, Lepromatous leprosy, Treponema pallidum, Neisseria meningiditis, UTI, Borrelia burgdorferi, Mycobacterium kansasii, Mycobacterium avium-intracellulare, Sinusitis, Actinomycosis, Yersinia pseudotuberculosis, Leptospira hebdomadis, Listeria monocytogenes, Brucellosis, Blastomycosis, Candida albicans, Allergic bronchopulmonary aspergillosis, Invasive aspergillosis, Cryptococcus neoformans, Psittacosis, Coccidioidomycosis, Histoplasmosis, Malaria, Toxoplasma, Sleeping sickness, Entamoeba histolytica, Visceral leishmaniasis, Fasciola hepatica, Epstein-Barr virus, Hepatitis B, HIV-1 disease, Newcastle disease
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Musculoskeletal / Ortho
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Osteomyelitis, Discitis, Polymyalgia rheumatica
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Neurologic
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Hereditary sensory and autonomic neuropathy type 3, Vitamin B12 deficiency
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Nutritional / Metabolic
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Vitamin B12 deficiency
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Obstetric/Gynecologic
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No underlying causes
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Oncologic
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Renal adenocarcinoma, Hodgkin's lymphoma, Pancreatic cancer, Angioimmunoblastic lymphadenopathy with dysproteinaemia, Paraneoplastic syndrome, Atrial myxoma
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Opthalmologic
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No underlying causes
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Overdose / Toxicity
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No underlying causes
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Psychiatric
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Factitious fever
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Pulmonary
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Lung abscess, Allergic bronchopulmonary aspergillosis, Invasive aspergillosis
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Renal / Electrolyte
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Acute pyelonephritis, Xanthogranulomatous pyelonephritis
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Rheum / Immune / Allergy
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Polyarteritis nodosa, Systemic lupus erythematosus, Polymyalgia rheumatica, Sarcoidosis, Polymyositis, Temporal arteritis, Juvenile chronic arthritis, Hyperimmunoglobulinemia D and periodic fever syndrome, Wegener's granulomatosis, Recurrent hereditary polyserositis, Disseminated Intravascular Coagulation, Still's Disease, Rheumatoid disease, Whipple's disease, Retroperitoneal fibrosis, Crohn's disease, Ulcerative colitis, Schnitzler syndrome
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Sexual
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No underlying causes
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Trauma
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No underlying causes
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Urologic
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No underlying causes
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Dental
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No underlying causes
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Miscellaneous
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Surgery complication, Fabry's disease
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Causes by Alphabetical Order
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- Periodic fever aphthous pharyngitis and cervical adenopathy
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References