Liposarcoma classification: Difference between revisions
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*Round cell liposarcoma | *Round cell liposarcoma | ||
*Pleiomorphic liposarcoma | *Pleiomorphic liposarcoma | ||
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*Positive in persons exposed to HDV | |||
*Persists, even after viral clearance | |||
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it is useful to think of liposarcomas as three large groups from a conceptual point of view. ALN/WDL, also termed atypical lipomatous neoplasm (ALN) when it occurs in superficial soft tissue or in the muscles of the extremity because of its low-grade behavior, and dedifferentiated liposarcoma (DL) comprise one subgroup. Widely disparate in terms of biologic behavior, they are closely related from a pathogenetic point of view because a subset of ALN/WDL histologically progresses to dedifferentiated sarcomas. With dedifferentiation, the tumor acquires metastatic potential, a phenomenon accompanied by additional cytogenetic abnormalities. The second group is myxoid liposarcoma that ranges in appearance from pure myxoid tumors at one extreme to poorly differentiated round cell (poorly differentiated myxoid) tumors at the other. Pleomorphic liposarcomas are rare, poorly characterized tumors, many of which resemble undifferentiated pleomorphic sarcoma, except for the presence of pleomorphic lipoblasts. Finally, a small number of liposarcomas exhibit unusual features or combine patterns not accounted for in the previous classification (liposarcomas of mixed type). These are best individualized and diagnosed as liposarcomas of mixed or unclassifiable type, recognizing that the number of such lesions is dwindling because of the ability of molecular testing to assign them to a category. | |||
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==References== | ==References== | ||
Revision as of 14:38, 19 September 2014
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Liposarcoma Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Liposarcoma classification On the Web |
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American Roentgen Ray Society Images of Liposarcoma classification |
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Risk calculators and risk factors for Liposarcoma classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]
Overview
Classification
Liposarcoma is one type of soft tissue sarcomas, which accounts for about 20% of the mesenchymal malignancies. Liposarcomas may be classified into different types, according to their histologic, cytogenetic, biologic and molecular features. The WHO has proposed the following classification of liposarcomas:[1][2]
- Well-diferentiated liposarcoma:
- Adipocytic or lipoma-like
- Inflammatory
- Sclerosing
- Dedifferentiated liposarcoma
- Myxoid liposarcoma
- Round cell liposarcoma
- Pleiomorphic liposarcoma
| Diagnostic Markers | Significance |
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References
- ↑ Weiss, Sharon (1994). Histological typing of soft tissue tumours. Berlin New York: Springer-Verlag. ISBN 3540567941.
- ↑ Dei Tos AP (2000). "Liposarcoma: new entities and evolving concepts". Ann Diagn Pathol. 4 (4): 252–66. doi:10.1053/adpa.2000.8133. PMID 10982304.