Liposarcoma laboratory findings: Difference between revisions
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*In cases of [[ureter]] or [[kidney]] involvement, an elevated [[creatinine]] and [[BUN]] may be seen. | *In cases of [[ureter]] or [[kidney]] involvement, an elevated [[creatinine]] and [[BUN]] may be seen. | ||
*[[Anemia]] may be present, specially if there is [[bleeding]] associated with the liposarcoma. <ref name="NennstielMollenhauer2014">{{cite journal|last1=Nennstiel|first1=Simon|last2=Mollenhauer|first2=Martin|last3=Schlag|first3=Christoph|last4=Becker|first4=Valentin|last5=Neu|first5=Bruno|last6=Hüser|first6=Norbert|last7=Gertler|first7=Ralf|last8=Schmid|first8=Roland M.|last9=von Delius|first9=Stefan|title=Small Bowel Pleomorphic Liposarcoma: A Rare Cause of Gastrointestinal Bleeding|journal=Case Reports in Gastrointestinal Medicine|volume=2014|year=2014|pages=1–4|issn=2090-6528|doi=10.1155/2014/391871}}</ref> | *[[Anemia]] may be present, specially if there is [[bleeding]] associated with the liposarcoma. <ref name="NennstielMollenhauer2014">{{cite journal|last1=Nennstiel|first1=Simon|last2=Mollenhauer|first2=Martin|last3=Schlag|first3=Christoph|last4=Becker|first4=Valentin|last5=Neu|first5=Bruno|last6=Hüser|first6=Norbert|last7=Gertler|first7=Ralf|last8=Schmid|first8=Roland M.|last9=von Delius|first9=Stefan|title=Small Bowel Pleomorphic Liposarcoma: A Rare Cause of Gastrointestinal Bleeding|journal=Case Reports in Gastrointestinal Medicine|volume=2014|year=2014|pages=1–4|issn=2090-6528|doi=10.1155/2014/391871}}</ref> | ||
* The level of D-dimer has been studied as a marker for the differential diagnosis of lipoma and well-differentiated liposarcoma, the latter having higher levels of D=dimer.<ref>{{Cite journal | |||
| author = [[Akira Yoshiyama]], [[Takeshi Morii]], [[Takashi Tajima]], [[Takayuki Aoyagi]], [[Keita Honya]], [[Kazuo Mochizuki]], [[Kazuhiko Satomi]] & [[Shoichi Ichimura]] | |||
| title = D-dimer Levels in the Differential Diagnosis Between Lipoma and Well-differentiated Liposarcoma | |||
| journal = [[Anticancer research]] | |||
| volume = 34 | |||
| issue = 9 | |||
| pages = 5181–5185 | |||
| year = 2014 | |||
| month = September | |||
| pmid = 25202112 | |||
}}</ref> | |||
==References== | ==References== | ||
Revision as of 18:55, 22 September 2014
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Liposarcoma Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Liposarcoma laboratory findings On the Web |
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American Roentgen Ray Society Images of Liposarcoma laboratory findings |
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Risk calculators and risk factors for Liposarcoma laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alejandro Lemor, M.D. [2]
Overview
Laboratory Findings
Biopsy
Although imaging assists in the diagnosis of liposarcoma, a biopsy is needed to confirm the disease and determine the histopathological subtype of liposarcoma.
| Subtype | Findings |
|---|---|
| Atypical Lipomatous Neoplasm (ALN)/Well-Differentiated Liposarcoma (WDL) | 4 subtypes: lipoma-like, sclerosing, spindle cell and inflammatory. Multivacuolated lipoblasts and spindle cells with a hyperchromatic nuclei. Fibrotic areas and atypical stroma cells may be observed. |
| Dedifferentiated Liposarcoma | Abrupt transition from a low-grade to a high-grade differentiation within the same mass of well-differentiated liposarcoma. |
| Myxoid Liposarcoma | Multinodular mass with round cells, hyaluronic acid matrix. High cellularity at the periphery and low cellularity inside the mass. Mitotic activity is normal and the nuclei is normochromatic. |
| Pleomorphic Liposarcoma | Pleomorphic lipoblasts with hyperchromatic nuclei, acidophilic cytoplasm and eosinophilic hyaline globules; spinde cells and multinucleated giant cells may be observed. |
| Mixed-type Liposarcoma | Mixed features of myxoid, pleomorphic and well-differentiated liposarcoma. |
| Table adapted from Fletcher C.D.M., Unni K.K., Mertens F. (Eds.): WHO Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone[1] and Enzinger and Weiss's Soft Tissue Tumors , 6th Edition [2] | |
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Laboratory Tests
- There are no specific laboratory test findings for the diagnosis of liposarcoma.
- In cases of ureter or kidney involvement, an elevated creatinine and BUN may be seen.
- Anemia may be present, specially if there is bleeding associated with the liposarcoma. [3]
- The level of D-dimer has been studied as a marker for the differential diagnosis of lipoma and well-differentiated liposarcoma, the latter having higher levels of D=dimer.[4]
References
- ↑ Fletcher, Christopher (2002). Pathology and genetics of tumours of soft tissue and bone. Lyon: IARC Press. ISBN 9283224132.
- ↑ Goldblum, John (2014). Enzinger and Weiss's soft tissue tumors. Philadelphia, PA: Saunders/Elsevier. ISBN 978-0-323-08834-3.
- ↑ Nennstiel, Simon; Mollenhauer, Martin; Schlag, Christoph; Becker, Valentin; Neu, Bruno; Hüser, Norbert; Gertler, Ralf; Schmid, Roland M.; von Delius, Stefan (2014). "Small Bowel Pleomorphic Liposarcoma: A Rare Cause of Gastrointestinal Bleeding". Case Reports in Gastrointestinal Medicine. 2014: 1–4. doi:10.1155/2014/391871. ISSN 2090-6528.
- ↑ Akira Yoshiyama, Takeshi Morii, Takashi Tajima, Takayuki Aoyagi, Keita Honya, Kazuo Mochizuki, Kazuhiko Satomi & Shoichi Ichimura (2014). "D-dimer Levels in the Differential Diagnosis Between Lipoma and Well-differentiated Liposarcoma". Anticancer research. 34 (9): 5181–5185. PMID 25202112. Unknown parameter
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