Anileridine: Difference between revisions

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{{drugbox
{{Drugbox
| IUPAC_name = ethyl 1-[2-(4-aminophenyl)ethyl]- 4-phenyl-piperidine-4-carboxylate
| Verifiedfields = changed
| verifiedrevid = 457130773
| IUPAC_name = Ethyl 1-[2-(4-aminophenyl)ethyl]-4-phenylpiperidine-4-carboxylate
| image = Anileridine.png
| image = Anileridine.png
| width = 150px
<!--Clinical data-->
| tradename = 
| Drugs.com = {{drugs.com|monograph|buprenorphine-hydrochloride}}
| pregnancy_category = 
| legal_AU = S8
| legal_CA = Rx-only
| legal_US = Schedule II
| legal_status = 
| routes_of_administration = Tablets, injection
<!--Pharmacokinetic data-->
| bioavailability = 
| protein_bound = > 95%
| metabolism = [[Liver|Hepatic]]
| elimination_half-life = 
<!--Identifiers-->
| CASNo_Ref = {{cascite|correct|CAS}}
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 144-14-9
| CAS_number = 144-14-9
| ATC_prefix = N01
| ATC_prefix = N01
| ATC_suffix = AH05
| ATC_suffix = AH05
| ATC_supplemental =  
| ATC_supplemental =
| PubChem = 8944
| PubChem = 8944
| DrugBank = APRD00741
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| C = 22 | H = 28 | N = 2 | O = 2
| DrugBank = DB00913
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 8600
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 71Q1A3O279
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D02941
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 61203
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 1201347
 
<!--Chemical data-->
| C=22 | H=28 | N=2 | O=2  
| molecular_weight = 352.47 g/mol
| molecular_weight = 352.47 g/mol
| smiles = O=C(OCC)C3(c1ccccc1)CCN(CCc2ccc(N)cc2)CC3
| InChI = 1/C22H28N2O2/c1-2-26-21(25)22(19-6-4-3-5-7-19)13-16-24(17-14-22)15-12-18-8-10-20(23)11-9-18/h3-11H,2,12-17,23H2,1H3
| InChIKey = LKYQLAWMNBFNJT-UHFFFAOYAF
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C22H28N2O2/c1-2-26-21(25)22(19-6-4-3-5-7-19)13-16-24(17-14-22)15-12-18-8-10-20(23)11-9-18/h3-11H,2,12-17,23H2,1H3
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = LKYQLAWMNBFNJT-UHFFFAOYSA-N
| melting_point = 83
| melting_point = 83
| bioavailability =
| protein_bound = > 95%
| metabolism = [[Liver|Hepatic]]
| elimination_half-life =
| pregnancy_category =
| legal_status = CII
| routes_of_administration =
}}
}}
'''Anileridine''' (trade name '''Leritine''') is a synthetic [[opioid]] and strong [[analgesic]] [[medication]].
__NOTOC__
 
{{SI}}
 
{{CMG}}
 
==Overview==
'''Anileridine''' (trade name: '''Leritine''') is a synthetic [[analgesic]] drug and is a member of the [[piperidine]] class of analgesic agents developed by Merck & Co. in the 1950s.<ref>{{US Patent|2897204}}</ref> It differs from [[pethidine]] (meperidine) in that the ''N''-methyl group of meperidine is replaced by an ''N''-aminophenethyl group, which increases its analgesic activity.
 
Anileridine is no longer manufactured in the US or Canada.<ref>{{Cite web |last= |first= |title=Discontinued Prescription Drug Products |publisher=Canadian Pharmacists' Association |date= |url=http://www.pharmacists.ca/content/hcp/tools/drugnews/discontinued.htm |accessdate=28 July 2008}}</ref>


==Administration==
==Administration==
As [[tablet]]s or [[Injection (medicine)|injection]].
As [[Tablet (pharmacy)|tablets]] or [[Injection (medicine)|injection]].<ref>{{Cite web |last= |first= |title=Pharmaceutical Information - LERITINE |publisher=RxMed |date= |url=http://www.rxmed.com/b.main/b2.pharmaceutical/b2.1.monographs/CPS-%20Monographs/CPS-%20%28General%20Monographs-%20L%29/LERITINE.html |accessdate=16 June 2010 }}</ref>


==Pharmacokinetics==
==Pharmacokinetics==
Anileridine usually takes effect within 15 minutes of either oral or intravenous administration, and lasts 2–3 hours.  It is mostly metabolized by the [[liver]].
Anileridine usually takes effect within 15 minutes of either oral or intravenous administration, and lasts 2–3 hours.<ref>{{Cite web |last= |first= |title=Anileridine Consumer Information |publisher=MedicineNet |date= |url=http://www.medicinenet.com/anileridine-oral_tablet/article.htm |accessdate=28 July 2008}}</ref> It is mostly metabolized by the [[liver]].
 
==External links==


==References==
{{Reflist|2}}


{{Analgesics}}
{{Analgesics}}
{{General anesthetics}}
{{General anesthetics}}
{{Opioidergics}}


{{opioids}}
[[Category:Piperidines]]
 
[[Category:Synthetic opioids]]
[[Category:Drugs]]
[[Category:General anesthetics]]
{{WikiDoc Help Menu}}
[[Category:Anilines]]
 
[[Category:Ethyl esters]]
 
[[Category:Mu-opioid agonists]]
 
[[Category:Analgesics]]
{{WikiDoc Sources}}

Revision as of 18:44, 8 April 2015

Anileridine
Clinical data
AHFS/Drugs.comMonograph
Routes of
administration		Tablets, injection
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding> 95%
MetabolismHepatic
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC22H28N2O2
Molar mass352.47 g/mol
3D model (JSmol)
Melting point83 °C (181.4 °F)
 ☒N☑Y (what is this?)  (verify)


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Anileridine (trade name: Leritine) is a synthetic analgesic drug and is a member of the piperidine class of analgesic agents developed by Merck & Co. in the 1950s.[1] It differs from pethidine (meperidine) in that the N-methyl group of meperidine is replaced by an N-aminophenethyl group, which increases its analgesic activity.

Anileridine is no longer manufactured in the US or Canada.[2]

Administration

As tablets or injection.[3]

Pharmacokinetics

Anileridine usually takes effect within 15 minutes of either oral or intravenous administration, and lasts 2–3 hours.[4] It is mostly metabolized by the liver.

References

  1. ↑ Template:US Patent
  2. ↑ "Discontinued Prescription Drug Products". Canadian Pharmacists' Association. Retrieved 28 July 2008.
  3. ↑ "Pharmaceutical Information - LERITINE". RxMed. Retrieved 16 June 2010.
  4. ↑ "Anileridine Consumer Information". MedicineNet. Retrieved 28 July 2008.

Template:General anesthetics

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