Liposarcoma risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Overview

Risk factors of liposarcoma includes chemical carcinogens, genetic disorders, radiation and immunodeficiency. These increases the risk of liposarcoma in general population.

Risk factors

Liposarcoma is associated with a number of risk factors. Few of them are listed below.

• Chemical carcinogens
  • Phenoxyacetic herbicides
  • Chlorophenols
  • Dioxin contaminations
  • Arsenic
  • Thorium dioxide(Thorotrast)

• Radiation
  • Risk has been found with adjuvant therapy of radiation for breast carcinoma. Risk increases with dose and a dose of 50 GY or more of radiation has been recorded with increased risk of sarcoma. The mean period between exposure to radiation and tumor diagnosis is 10 years.

• Immunodeficiency
  • Regional acquired immunodeficiency is sometimes associated with liposarcoma

• Genetic susceptibility
  • Li-Fraumeni syndrome
  • Neurofibromatosis (NF1; von Recklinghausen disease)
  • Gardner syndrome (Familial adenomatous polyposis)
  • Retinoblastoma
  • Werner syndrome
  • Nevoid basal cell carcinoma (Gorlin syndrome)

• Viral infection

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