Liposarcoma differential diagnosis: Difference between revisions
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{{CMG}} ; {{AE}} {{Ammu}} | {{CMG}} ; {{AE}} {{Ammu}} | ||
==Overview== | ==Overview== | ||
Liposarcoma must be differentiated from other diseases that cause a painless, | Liposarcoma must be differentiated from other diseases that cause a painless, [[Mass|growing mass]] such as [[Lipoma|spindle cell lipoma]], [[neurofibroma]], [[dermatofibrosarcoma protuberans]], and [[malignant peripheral nerve sheath tumor]]. | ||
==Differential diagnosis== | ==Differential diagnosis== | ||
Revision as of 14:36, 26 August 2015
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Liposarcoma Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
Liposarcoma must be differentiated from other diseases that cause a painless, growing mass such as spindle cell lipoma, neurofibroma, dermatofibrosarcoma protuberans, and malignant peripheral nerve sheath tumor.
Differential diagnosis
Differential diagnosis of liposarcoma includes nonadipocytic lesions such as:[1]
- Inflammatory myofibroblastic tumor
- Castleman’s disease
- Spindle cell lipoma
- Neurofibroma
- Dermatofibrosarcoma protuberans
- Malignant peripheral nerve sheath tumor
| Disease | Description |
|---|---|
| Spindle cell lipoma | Composed of bland, sometimes palisading, CD34-positive spindle cells, ad- mixed with eosinophilic refractile collagen bundles |
| Neurofibroma | Characterized by a less cellular S-100– positive spindle cell proliferation with wavy nuclei |
| Dermatofibrosarcoma protuberans | Cytologically bland, monomorphic CD34-positive spindle cell proliferation organized in a distinctive storiform growth pattern and characterized by tendency to infiltrate the surrounding fat in a peculiar ‘‘honeycomb’’ pattern |
| Malignant peripheral nerve sheath tumor | Generally highly cellular tumors composed of tapering or wavy spindle cells featuring perivascular accentuation and focal S-100– positive immunoreactivity in approximately 50% of cases[1] |
References
- ↑ 1.0 1.1 Dei Tos AP (2000). "Liposarcoma: new entities and evolving concepts". Ann Diagn Pathol. 4 (4): 252–66. doi:10.1053/adpa.2000.8133. PMID 10982304.