VIPoma overview: Difference between revisions
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==Overview== | ==Overview== | ||
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The massive amounts of VIP in turn cause profound and chronic '''w'''atery '''d'''[[diarrhea|iarrhea]] and resultant [[dehydration]], '''h'''[[hypokalemia|ypokalemia]], '''a'''[[achlorhydria|chlorhydria]] (hence '''WDHA-syndrome''', or '''pancreatic cholera syndrome'''), acidosis, [[vasodilation]] ([[flushing (physiology)|flushing]] and [[hypotension]]), [[hypercalcemia]] and [[hyperglycemia]].<ref>Mansour JC, Chen H. Pancreatic endocrine tumors. ''J Surg Res'' 2004; '''120''': 139-61. PMID 15172200</ref> | The massive amounts of VIP in turn cause profound and chronic '''w'''atery '''d'''[[diarrhea|iarrhea]] and resultant [[dehydration]], '''h'''[[hypokalemia|ypokalemia]], '''a'''[[achlorhydria|chlorhydria]] (hence '''WDHA-syndrome''', or '''pancreatic cholera syndrome'''), acidosis, [[vasodilation]] ([[flushing (physiology)|flushing]] and [[hypotension]]), [[hypercalcemia]] and [[hyperglycemia]].<ref>Mansour JC, Chen H. Pancreatic endocrine tumors. ''J Surg Res'' 2004; '''120''': 139-61. PMID 15172200</ref> | ||
==Historical Perspective== | |||
==Pathophysiology== | |||
==Causes== | |||
==Differential Diagnosis== | |||
==References== | ==References== | ||
Revision as of 20:35, 27 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Overview
A VIPoma (also known as Verner Morrison syndrome, after the physicians who first described it [1]) is a rare (1 per 10,000,000 per year) endocrine tumor, usually (about 90%) originating in the pancreas, which produces vasoactive intestinal peptide (VIP).
It is a syndrome caused by non-β islet-cell tumors. It may be associated with multiple endocrine neoplasia.
The massive amounts of VIP in turn cause profound and chronic watery diarrhea and resultant dehydration, hypokalemia, achlorhydria (hence WDHA-syndrome, or pancreatic cholera syndrome), acidosis, vasodilation (flushing and hypotension), hypercalcemia and hyperglycemia.[2]