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Salivary gland tumor may be classified according to the World Health Organization into five groups: [[malignant]] [[epithelial]] [[tumors]], [[benign]] [[epithelial]] [[tumors]], [[soft tissue tumors]], hematolymphoid tumors, and secondary tumors.<ref name="wiki">  Salivary gland neoplasm. Wikipedia(2015) https://en.wikipedia.org/wiki/Salivary_gland_neoplasm Accessed on November 8, 2015</ref>
Salivary gland tumor may be classified according to the World Health Organization into five groups: [[malignant]] [[epithelial]] [[tumors]], [[benign]] [[epithelial]] [[tumors]], [[soft tissue tumors]], hematolymphoid tumors, and secondary tumors.<ref name="wiki">  Salivary gland neoplasm. Wikipedia(2015) https://en.wikipedia.org/wiki/Salivary_gland_neoplasm Accessed on November 8, 2015</ref>
==Classification==
==Classification==
The [[parotid gland]] is the most frequent site of salivary gland tumors which accounts for approximately 80 to 85 percent of these tumors.<ref>Barnes, Leon. Pathology and genetics of head and neck tumours. Lyon: IARC Press, 2005. Print.</ref><ref>{{Cite journal
| author = [[Marco Guzzo]], [[Laura D. Locati]], [[Franz J. Prott]], [[Gemma Gatta]], [[Mark McGurk]] & [[Lisa Licitra]] | title = Major and minor salivary gland tumors
| journal = [[Critical reviews in oncology/hematology]] | volume = 74 | issue = 2 | pages = 134–148 | year = 2010 | month = May | doi = 10.1016/j.critrevonc.2009.10.004
| pmid = 019939701}}</ref> About 75 percent of parotid lesions are benign and approximately 25 percent are malignant.<ref>{{Cite journal | author = [[R. H. Spiro]]
| title = Salivary neoplasms: overview of a 35-year experience with 2,807 patients | journal = [[Head & neck surgery]] | volume = 8 | issue = 3 | pages = 177–184 | year = 1986 | month = January-February | pmid = 03744850}}</ref>
Less frequently, salivary gland tumors originate in the [[sublingual]], [[submandibular]], and minor salivary glands, which are located throughout the submucosa of the upper aerodigestive tract and  mouth.<ref>{{Cite journal | author = [[Marco Guzzo]], [[Laura D. Locati]], [[Franz J. Prott]], [[Gemma Gatta]], [[Mark McGurk]] & [[Lisa Licitra]]
| title = Major and minor salivary gland tumors | journal = [[Critical reviews in oncology/hematology]] | volume = 74 | issue = 2 | pages = 134–148 | year = 2010
| month = May | doi = 10.1016/j.critrevonc.2009.10.004 | pmid = 019939701}}</ref>
*In comparison to tumors arising in the parotid, 70 to 90 percent of sublingual gland tumors, 50 to 75 percent of minor salivary gland tumors, and 40 to 45 percent of [[submandibular]] gland tumors are [[malignant]]. Approximately 85% of salivary gland tumors occur in the parotid glands, followed by the minor salivary glands and submandibular, and about 1% occur in the [[sublingual]] [[glands]]. Overall approximately 80% of all parotid masses are benign.<ref name="radio">  Salivary gland tumors. Radiopedia(2015) http://radiopaedia.org/articles/salivary-gland-tumours Accessed on November 8, 2015</ref>
*In comparison to tumors arising in the parotid, 70 to 90 percent of sublingual gland tumors, 50 to 75 percent of minor salivary gland tumors, and 40 to 45 percent of [[submandibular]] gland tumors are [[malignant]]. Approximately 85% of salivary gland tumors occur in the parotid glands, followed by the minor salivary glands and submandibular, and about 1% occur in the [[sublingual]] [[glands]]. Overall approximately 80% of all parotid masses are benign.<ref name="radio">  Salivary gland tumors. Radiopedia(2015) http://radiopaedia.org/articles/salivary-gland-tumours Accessed on November 8, 2015</ref>
*Histologically, [[pleomorphic adenoma]] is the most common type of benign salivary gland tumor, which comprises about half of all salivary tumors. Other rarer benign salivary gland tumors include  [[basal cell]] [[adenoma]], [[Warthin]] [[tumor]], and [[canalicular adenoma]]. The most common malignant salivary gland tumors are [[adenoid]] [[cystic]] carcinoma and [[mucoepidermoid]] carcinoma, which together constitute approximately one-half of all malignant salivary gland tumors.
*Histologically, [[pleomorphic adenoma]] is the most common type of benign salivary gland tumor, which comprises about half of all salivary tumors. Other rarer benign salivary gland tumors include  [[basal cell]] [[adenoma]], [[Warthin]] [[tumor]], and [[canalicular adenoma]]. The most common malignant salivary gland tumors are [[adenoid]] [[cystic]] carcinoma and [[mucoepidermoid]] carcinoma, which together constitute approximately one-half of all malignant salivary gland tumors.

Revision as of 03:58, 14 November 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]}Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]

Overview

Salivary gland tumor may be classified according to the World Health Organization into five groups: malignant epithelial tumors, benign epithelial tumors, soft tissue tumors, hematolymphoid tumors, and secondary tumors.[1]

Classification

  • In comparison to tumors arising in the parotid, 70 to 90 percent of sublingual gland tumors, 50 to 75 percent of minor salivary gland tumors, and 40 to 45 percent of submandibular gland tumors are malignant. Approximately 85% of salivary gland tumors occur in the parotid glands, followed by the minor salivary glands and submandibular, and about 1% occur in the sublingual glands. Overall approximately 80% of all parotid masses are benign.[2]
  • Histologically, pleomorphic adenoma is the most common type of benign salivary gland tumor, which comprises about half of all salivary tumors. Other rarer benign salivary gland tumors include basal cell adenoma, Warthin tumor, and canalicular adenoma. The most common malignant salivary gland tumors are adenoid cystic carcinoma and mucoepidermoid carcinoma, which together constitute approximately one-half of all malignant salivary gland tumors.

Due to diverse nature of salivary gland neoplasms, many different terms and classification systems have been used. Currently, the system proposed by the World Health Organization in 2004, which classifies salivary neoplasms as primary or secondary, benign or malignant, and also by tissue of origin is the most widely used system. This system defines five broad categories of salivary gland neoplasms:[1]

Malignant epithelial tumors

Benign epithelial tumors

Soft tissue tumors

Hematolymphoid tumors

Secondary tumors

Secondary tumor is a tumor which has metastasized to the salivary gland from a distant location.

Tumors not included in the WHO classification above, include:

Hybrid tumor is a tumor displaying combined forms of histologic tumor types.
  • Hybrid carcinoma
  • Others
  • Others
    • Keratocystoma
    • Sialolipoma

References

  1. ↑ 1.0 1.1 Salivary gland neoplasm. Wikipedia(2015) https://en.wikipedia.org/wiki/Salivary_gland_neoplasm Accessed on November 8, 2015
  2. ↑ Salivary gland tumors. Radiopedia(2015) http://radiopaedia.org/articles/salivary-gland-tumours Accessed on November 8, 2015

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