Mast cell leukemia overview: Difference between revisions
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{{CMG}}; {{AE}}{{NM}} | {{CMG}}; {{AE}}{{NM}} | ||
==Overview== | ==Overview== | ||
'''Mast cell leukemia''' was first described in 1906 by G. Joachim.<ref name="Georgin-LavialleLhermitte2012">{{cite journal|last1=Georgin-Lavialle|first1=S.|last2=Lhermitte|first2=L.|last3=Dubreuil|first3=P.|last4=Chandesris|first4=M.-O.|last5=Hermine|first5=O.|last6=Damaj|first6=G.|title=Mast cell leukemia|journal=Blood|volume=121|issue=8|year=2012|pages=1285–1295|issn=0006-4971|doi=10.1182/blood-2012-07-442400}}</ref> Mast cell leukemia may be classified into two categories based on prognosis.<ref name="Georgin-LavialleLhermitte2012">{{cite journal|last1=Georgin-Lavialle|first1=S.|last2=Lhermitte|first2=L.|last3=Dubreuil|first3=P.|last4=Chandesris|first4=M.-O.|last5=Hermine|first5=O.|last6=Damaj|first6=G.|title=Mast cell leukemia|journal=Blood|volume=121|issue=8|year=2012|pages=1285–1295|issn=0006-4971|doi=10.1182/blood-2012-07-442400}}</ref> Based on the duration of symptoms, mast cell leukemia may be classified into either acute or chronic.<ref name="SaviniRondoni2015">{{cite journal|last1=Savini|first1=P.|last2=Rondoni|first2=M.|last3=Poletti|first3=G.|last4=Lanzi|first4=A.|last5=Quercia|first5=O.|last6=Soverini|first6=S.|last7=De Benedittis|first7=C.|last8=Musardo|first8=G.|last9=Martinelli|first9=G.|last10=Stefanini|first10=G. F.|title=Serum Total Tryptase Level Confirms Itself as a More Reliable Marker of Mast Cells Burden in Mast Cell Leukaemia (Aleukaemic Variant)|journal=Case Reports in Hematology|volume=2015|year=2015|pages=1–4|issn=2090-6560|doi=10.1155/2015/737302}}</ref> Genes involved in the pathogenesis of mast cell leukemia include ''KIT'' D816V, and non-''KIT'' D816V.<ref name=" | '''Mast cell leukemia''' was first described in 1906 by G. Joachim.<ref name="Georgin-LavialleLhermitte2012">{{cite journal|last1=Georgin-Lavialle|first1=S.|last2=Lhermitte|first2=L.|last3=Dubreuil|first3=P.|last4=Chandesris|first4=M.-O.|last5=Hermine|first5=O.|last6=Damaj|first6=G.|title=Mast cell leukemia|journal=Blood|volume=121|issue=8|year=2012|pages=1285–1295|issn=0006-4971|doi=10.1182/blood-2012-07-442400}}</ref> Mast cell leukemia may be classified into two categories based on prognosis.<ref name="Georgin-LavialleLhermitte2012">{{cite journal|last1=Georgin-Lavialle|first1=S.|last2=Lhermitte|first2=L.|last3=Dubreuil|first3=P.|last4=Chandesris|first4=M.-O.|last5=Hermine|first5=O.|last6=Damaj|first6=G.|title=Mast cell leukemia|journal=Blood|volume=121|issue=8|year=2012|pages=1285–1295|issn=0006-4971|doi=10.1182/blood-2012-07-442400}}</ref> Based on the duration of symptoms, mast cell leukemia may be classified into either acute or chronic.<ref name="SaviniRondoni2015">{{cite journal|last1=Savini|first1=P.|last2=Rondoni|first2=M.|last3=Poletti|first3=G.|last4=Lanzi|first4=A.|last5=Quercia|first5=O.|last6=Soverini|first6=S.|last7=De Benedittis|first7=C.|last8=Musardo|first8=G.|last9=Martinelli|first9=G.|last10=Stefanini|first10=G. F.|title=Serum Total Tryptase Level Confirms Itself as a More Reliable Marker of Mast Cells Burden in Mast Cell Leukaemia (Aleukaemic Variant)|journal=Case Reports in Hematology|volume=2015|year=2015|pages=1–4|issn=2090-6560|doi=10.1155/2015/737302}}</ref> Genes involved in the pathogenesis of mast cell leukemia include ''KIT'' D816V, and non-''KIT'' D816V.<ref name="Georgin-LavialleLhermitte2012">{{cite journal|last1=Georgin-Lavialle|first1=S.|last2=Lhermitte|first2=L.|last3=Dubreuil|first3=P.|last4=Chandesris|first4=M.-O.|last5=Hermine|first5=O.|last6=Damaj|first6=G.|title=Mast cell leukemia|journal=Blood|volume=121|issue=8|year=2012|pages=1285–1295|issn=0006-4971|doi=10.1182/blood-2012-07-442400}}</ref><ref name="JorisGeorgin-Lavialle2012">{{cite journal|last1=Joris|first1=Magalie|last2=Georgin-Lavialle|first2=Sophie|last3=Chandesris|first3=Marie-Olivia|last4=Lhermitte|first4=Ludovic|last5=Claisse|first5=Jean-François|last6=Canioni|first6=Danielle|last7=Hanssens|first7=Katia|last8=Damaj|first8=Gandhi|last9=Hermine|first9=Olivier|last10=Hamidou|first10=Mohammed|title=Mast Cell Leukaemia: c-KIT Mutations Are Not Always Positive|journal=Case Reports in Hematology|volume=2012|year=2012|pages=1–6|issn=2090-6560|doi=10.1155/2012/517546}}</ref><ref name="KristensenVestergaard2011">{{cite journal|last1=Kristensen|first1=Thomas|last2=Vestergaard|first2=Hanne|last3=Møller|first3=Michael Boe|title=Improved Detection of the KIT D816V Mutation in Patients with Systemic Mastocytosis Using a Quantitative and Highly Sensitive Real-Time qPCR Assay|journal=The Journal of Molecular Diagnostics|volume=13|issue=2|year=2011|pages=180–188|issn=15251578|doi=10.1016/j.jmoldx.2010.10.004}}</ref> On microscopic histopathological analysis, multifocal sheets, and clusters of mast cells in bone marrow sections are findings of mast cell leukemia.<ref name="ValentSotlar2014">{{cite journal|last1=Valent|first1=P.|last2=Sotlar|first2=K.|last3=Sperr|first3=W. R.|last4=Escribano|first4=L.|last5=Yavuz|first5=S.|last6=Reiter|first6=A.|last7=George|first7=T. I.|last8=Kluin-Nelemans|first8=H. C.|last9=Hermine|first9=O.|last10=Butterfield|first10=J. H.|last11=Hagglund|first11=H.|last12=Ustun|first12=C.|last13=Hornick|first13=J. L.|last14=Triggiani|first14=M.|last15=Radia|first15=D.|last16=Akin|first16=C.|last17=Hartmann|first17=K.|last18=Gotlib|first18=J.|last19=Schwartz|first19=L. B.|last20=Verstovsek|first20=S.|last21=Orfao|first21=A.|last22=Metcalfe|first22=D. D.|last23=Arock|first23=M.|last24=Horny|first24=H.- P.|title=Refined diagnostic criteria and classification of mast cell leukemia (MCL) and myelomastocytic leukemia (MML): a consensus proposal|journal=Annals of Oncology|volume=25|issue=9|year=2014|pages=1691–1700|issn=0923-7534|doi=10.1093/annonc/mdu047}}</ref> | ||
==Historical Perspective== | ==Historical Perspective== | ||
Mast cell leukemia was first described in 1906 by G. Joachim.<ref name="Georgin-LavialleLhermitte2012">{{cite journal|last1=Georgin-Lavialle|first1=S.|last2=Lhermitte|first2=L.|last3=Dubreuil|first3=P.|last4=Chandesris|first4=M.-O.|last5=Hermine|first5=O.|last6=Damaj|first6=G.|title=Mast cell leukemia|journal=Blood|volume=121|issue=8|year=2012|pages=1285–1295|issn=0006-4971|doi=10.1182/blood-2012-07-442400}}</ref> | Mast cell leukemia was first described in 1906 by G. Joachim.<ref name="Georgin-LavialleLhermitte2012">{{cite journal|last1=Georgin-Lavialle|first1=S.|last2=Lhermitte|first2=L.|last3=Dubreuil|first3=P.|last4=Chandesris|first4=M.-O.|last5=Hermine|first5=O.|last6=Damaj|first6=G.|title=Mast cell leukemia|journal=Blood|volume=121|issue=8|year=2012|pages=1285–1295|issn=0006-4971|doi=10.1182/blood-2012-07-442400}}</ref> | ||
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Mast cell leukemia may be classified into two categories based on prognosis.<ref name="Georgin-LavialleLhermitte2012">{{cite journal|last1=Georgin-Lavialle|first1=S.|last2=Lhermitte|first2=L.|last3=Dubreuil|first3=P.|last4=Chandesris|first4=M.-O.|last5=Hermine|first5=O.|last6=Damaj|first6=G.|title=Mast cell leukemia|journal=Blood|volume=121|issue=8|year=2012|pages=1285–1295|issn=0006-4971|doi=10.1182/blood-2012-07-442400}}</ref> Based on the duration of symptoms, mast cell leukemia may be classified into either acute or chronic.<ref name="SaviniRondoni2015">{{cite journal|last1=Savini|first1=P.|last2=Rondoni|first2=M.|last3=Poletti|first3=G.|last4=Lanzi|first4=A.|last5=Quercia|first5=O.|last6=Soverini|first6=S.|last7=De Benedittis|first7=C.|last8=Musardo|first8=G.|last9=Martinelli|first9=G.|last10=Stefanini|first10=G. F.|title=Serum Total Tryptase Level Confirms Itself as a More Reliable Marker of Mast Cells Burden in Mast Cell Leukaemia (Aleukaemic Variant)|journal=Case Reports in Hematology|volume=2015|year=2015|pages=1–4|issn=2090-6560|doi=10.1155/2015/737302}}</ref> | Mast cell leukemia may be classified into two categories based on prognosis.<ref name="Georgin-LavialleLhermitte2012">{{cite journal|last1=Georgin-Lavialle|first1=S.|last2=Lhermitte|first2=L.|last3=Dubreuil|first3=P.|last4=Chandesris|first4=M.-O.|last5=Hermine|first5=O.|last6=Damaj|first6=G.|title=Mast cell leukemia|journal=Blood|volume=121|issue=8|year=2012|pages=1285–1295|issn=0006-4971|doi=10.1182/blood-2012-07-442400}}</ref> Based on the duration of symptoms, mast cell leukemia may be classified into either acute or chronic.<ref name="SaviniRondoni2015">{{cite journal|last1=Savini|first1=P.|last2=Rondoni|first2=M.|last3=Poletti|first3=G.|last4=Lanzi|first4=A.|last5=Quercia|first5=O.|last6=Soverini|first6=S.|last7=De Benedittis|first7=C.|last8=Musardo|first8=G.|last9=Martinelli|first9=G.|last10=Stefanini|first10=G. F.|title=Serum Total Tryptase Level Confirms Itself as a More Reliable Marker of Mast Cells Burden in Mast Cell Leukaemia (Aleukaemic Variant)|journal=Case Reports in Hematology|volume=2015|year=2015|pages=1–4|issn=2090-6560|doi=10.1155/2015/737302}}</ref> | ||
==Pathophysiology== | ==Pathophysiology== | ||
Genes involved in the pathogenesis of mast cell leukemia include ''KIT'' D816V, and non-''KIT'' D816V.<ref name=" | Genes involved in the pathogenesis of mast cell leukemia include ''KIT'' D816V, and non-''KIT'' D816V.<ref name="Georgin-LavialleLhermitte2012">{{cite journal|last1=Georgin-Lavialle|first1=S.|last2=Lhermitte|first2=L.|last3=Dubreuil|first3=P.|last4=Chandesris|first4=M.-O.|last5=Hermine|first5=O.|last6=Damaj|first6=G.|title=Mast cell leukemia|journal=Blood|volume=121|issue=8|year=2012|pages=1285–1295|issn=0006-4971|doi=10.1182/blood-2012-07-442400}}</ref><ref name="JorisGeorgin-Lavialle2012">{{cite journal|last1=Joris|first1=Magalie|last2=Georgin-Lavialle|first2=Sophie|last3=Chandesris|first3=Marie-Olivia|last4=Lhermitte|first4=Ludovic|last5=Claisse|first5=Jean-François|last6=Canioni|first6=Danielle|last7=Hanssens|first7=Katia|last8=Damaj|first8=Gandhi|last9=Hermine|first9=Olivier|last10=Hamidou|first10=Mohammed|title=Mast Cell Leukaemia: c-KIT Mutations Are Not Always Positive|journal=Case Reports in Hematology|volume=2012|year=2012|pages=1–6|issn=2090-6560|doi=10.1155/2012/517546}}</ref><ref name="KristensenVestergaard2011">{{cite journal|last1=Kristensen|first1=Thomas|last2=Vestergaard|first2=Hanne|last3=Møller|first3=Michael Boe|title=Improved Detection of the KIT D816V Mutation in Patients with Systemic Mastocytosis Using a Quantitative and Highly Sensitive Real-Time qPCR Assay|journal=The Journal of Molecular Diagnostics|volume=13|issue=2|year=2011|pages=180–188|issn=15251578|doi=10.1016/j.jmoldx.2010.10.004}}</ref> On microscopic histopathological analysis, multifocal sheets, and clusters of mast cells in bone marrow sections are findings of mast cell leukemia.<ref name="ValentSotlar2014">{{cite journal|last1=Valent|first1=P.|last2=Sotlar|first2=K.|last3=Sperr|first3=W. R.|last4=Escribano|first4=L.|last5=Yavuz|first5=S.|last6=Reiter|first6=A.|last7=George|first7=T. I.|last8=Kluin-Nelemans|first8=H. C.|last9=Hermine|first9=O.|last10=Butterfield|first10=J. H.|last11=Hagglund|first11=H.|last12=Ustun|first12=C.|last13=Hornick|first13=J. L.|last14=Triggiani|first14=M.|last15=Radia|first15=D.|last16=Akin|first16=C.|last17=Hartmann|first17=K.|last18=Gotlib|first18=J.|last19=Schwartz|first19=L. B.|last20=Verstovsek|first20=S.|last21=Orfao|first21=A.|last22=Metcalfe|first22=D. D.|last23=Arock|first23=M.|last24=Horny|first24=H.- P.|title=Refined diagnostic criteria and classification of mast cell leukemia (MCL) and myelomastocytic leukemia (MML): a consensus proposal|journal=Annals of Oncology|volume=25|issue=9|year=2014|pages=1691–1700|issn=0923-7534|doi=10.1093/annonc/mdu047}}</ref> | ||
==Causes== | ==Causes== | ||
==Differentiating Mast cell leukemia from other Diseases== | ==Differentiating Mast cell leukemia from other Diseases== | ||
Revision as of 14:15, 30 November 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]
Overview
Mast cell leukemia was first described in 1906 by G. Joachim.[1] Mast cell leukemia may be classified into two categories based on prognosis.[1] Based on the duration of symptoms, mast cell leukemia may be classified into either acute or chronic.[2] Genes involved in the pathogenesis of mast cell leukemia include KIT D816V, and non-KIT D816V.[1][3][4] On microscopic histopathological analysis, multifocal sheets, and clusters of mast cells in bone marrow sections are findings of mast cell leukemia.[5]
Historical Perspective
Mast cell leukemia was first described in 1906 by G. Joachim.[1]
Classification
Mast cell leukemia may be classified into two categories based on prognosis.[1] Based on the duration of symptoms, mast cell leukemia may be classified into either acute or chronic.[2]
Pathophysiology
Genes involved in the pathogenesis of mast cell leukemia include KIT D816V, and non-KIT D816V.[1][3][4] On microscopic histopathological analysis, multifocal sheets, and clusters of mast cells in bone marrow sections are findings of mast cell leukemia.[5]
Causes
Differentiating Mast cell leukemia from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
History and symptoms
Physical Examination
Laboratory Findings
CT
MRI
Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical therapy
Surgery
Prevention
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Georgin-Lavialle, S.; Lhermitte, L.; Dubreuil, P.; Chandesris, M.-O.; Hermine, O.; Damaj, G. (2012). "Mast cell leukemia". Blood. 121 (8): 1285–1295. doi:10.1182/blood-2012-07-442400. ISSN 0006-4971.
- ↑ 2.0 2.1 Savini, P.; Rondoni, M.; Poletti, G.; Lanzi, A.; Quercia, O.; Soverini, S.; De Benedittis, C.; Musardo, G.; Martinelli, G.; Stefanini, G. F. (2015). "Serum Total Tryptase Level Confirms Itself as a More Reliable Marker of Mast Cells Burden in Mast Cell Leukaemia (Aleukaemic Variant)". Case Reports in Hematology. 2015: 1–4. doi:10.1155/2015/737302. ISSN 2090-6560.
- ↑ 3.0 3.1 Joris, Magalie; Georgin-Lavialle, Sophie; Chandesris, Marie-Olivia; Lhermitte, Ludovic; Claisse, Jean-François; Canioni, Danielle; Hanssens, Katia; Damaj, Gandhi; Hermine, Olivier; Hamidou, Mohammed (2012). "Mast Cell Leukaemia: c-KIT Mutations Are Not Always Positive". Case Reports in Hematology. 2012: 1–6. doi:10.1155/2012/517546. ISSN 2090-6560.
- ↑ 4.0 4.1 Kristensen, Thomas; Vestergaard, Hanne; Møller, Michael Boe (2011). "Improved Detection of the KIT D816V Mutation in Patients with Systemic Mastocytosis Using a Quantitative and Highly Sensitive Real-Time qPCR Assay". The Journal of Molecular Diagnostics. 13 (2): 180–188. doi:10.1016/j.jmoldx.2010.10.004. ISSN 1525-1578.
- ↑ 5.0 5.1 Valent, P.; Sotlar, K.; Sperr, W. R.; Escribano, L.; Yavuz, S.; Reiter, A.; George, T. I.; Kluin-Nelemans, H. C.; Hermine, O.; Butterfield, J. H.; Hagglund, H.; Ustun, C.; Hornick, J. L.; Triggiani, M.; Radia, D.; Akin, C.; Hartmann, K.; Gotlib, J.; Schwartz, L. B.; Verstovsek, S.; Orfao, A.; Metcalfe, D. D.; Arock, M.; Horny, H.- P. (2014). "Refined diagnostic criteria and classification of mast cell leukemia (MCL) and myelomastocytic leukemia (MML): a consensus proposal". Annals of Oncology. 25 (9): 1691–1700. doi:10.1093/annonc/mdu047. ISSN 0923-7534.