Esthesioneuroblastoma classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]

Overview

Esthesioneuroblastomas may be classified into two subtypes neuroblastoma proper and neuroendocrine carcinoma based on histopathology.

Classification

• Neuroblastomas proper
  • Neuroblastomas proper has a histologic presentation similar to that of peripheral neuroblastomas of childhood.
  • Esthesioneuroblastomas is composed of sheets of poorly demarcated groups of cells separated by fine connective tissue trabeculae.
  • The cells are small and typically show no mitotic activity.between the cells.
  • Rosettes of the Homer-Wright type are present.
  • On electronic microscopy, there is the presence of a dendritic cytoplasmic process with accumulations of small core granules within the process.
  • Neuroblastomas proper contain fibrillary material

• Neuroendocrine carcinomas.
  • Neuroendocrine carcinomas is admixture with glands.
  • In neuroendocrine carcinomas, a neurofibrillary component is absent, and the growth pattern is that of solid nests without rosettes.
  • Dense core granules similar to those of neuroblastoma are present in the cytoplasm and cytoplasmic extensions.