Esthesioneuroblastoma classification: Difference between revisions
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==Overview== | ==Overview== | ||
Based on the duration of symptoms, esthesioneuroblastoma may be classified into two subtypes [[neuroblastoma]] proper and | Based on the duration of symptoms, esthesioneuroblastoma may be classified into two subtypes [[neuroblastoma]] proper and neuroendocrine carcinomas.<ref name="pmid7483011">{{cite journal| author=Min KW| title=Usefulness of electron microscopy in the diagnosis of "small" round cell tumors of the sinonasal region. | journal=Ultrastruct Pathol | year= 1995 | volume= 19 | issue= 5 | pages= 347-63 | pmid=7483011 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7483011 }} </ref> | ||
==Classification== | ==Classification== | ||
*Neuroblastomas proper | *Neuroblastomas proper | ||
Revision as of 15:08, 27 January 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
Based on the duration of symptoms, esthesioneuroblastoma may be classified into two subtypes neuroblastoma proper and neuroendocrine carcinomas.[1]
Classification
- Neuroblastomas proper
- Neuroblastomas proper has a histologic presentation similar to that of peripheral neuroblastomas of childhood.
- Esthesioneuroblastomas is composed of sheets of poorly demarcated groups of cells separated by fine connective tissue trabeculae.
- The cells are small and typically show no mitotic activity.between the cells.
- Rosettes of the Homer-Wright type are present.
- On electronic microscopy, there is the presence of a dendritic cytoplasmic process with accumulations of small core granules within the process.
- Neuroblastomas proper contain fibrillary material
- Neuroendocrine carcinomas.
- Neuroendocrine carcinomas is admixture with glands.
- In neuroendocrine carcinomas, a neurofibrillary component is absent, and the growth pattern is that of solid nests without rosettes.
- Dense core granules similar to those of neuroblastoma are present in the cytoplasm and cytoplasmic extensions.
References
- ↑ Min KW (1995). "Usefulness of electron microscopy in the diagnosis of "small" round cell tumors of the sinonasal region". Ultrastruct Pathol. 19 (5): 347–63. PMID 7483011.