Esthesioneuroblastoma classification

Esthesioneuroblastoma Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Esthesioneuroblastoma from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Staging
History and Symptoms
Physical Examination
Laboratory Findings
CT
MRI
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Esthesioneuroblastoma classification On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Esthesioneuroblastoma classification All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Esthesioneuroblastoma classification
CDC on Esthesioneuroblastoma classification
Esthesioneuroblastoma classification in the news
Blogs on Esthesioneuroblastoma classification
Directions to Hospitals Treating Esthesioneuroblastoma
Risk calculators and risk factors for Esthesioneuroblastoma classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]

Overview

Based on the duration of symptoms, esthesioneuroblastoma may be classified into two subtypes: neuroblastoma proper and neuroendocrine carcinomas.

Classification

• Neuroblastoma proper
  • Neuroblastoma proper has a histologic presentation similar to that of peripheral neuroblastomas of childhood.
  • Esthesioneuroblastoma is composed of sheets of poorly demarcated groups of cells separated by fine connective tissue trabeculae.
  • The cells are small and typically show no mitotic activity between the cells.
  • Rosettes of the Homer-Wright type are present.
  • On electronic microscopy, there is the presence of a dendritic cytoplasmic process with accumulations of small core granules within the process.
  • Neuroblastomas proper contain fibrillary material.

• Neuroendocrine carcinomas
  • Neuroendocrine carcinoma is admixture with glands.
  • A neurofibrillary component is absent and the growth pattern is that of solid nests without rosettes.
  • Dense core granules similar to those of neuroblastomas are present in the cytoplasm and cytoplasmic extensions.