Hemophilia A causes: Difference between revisions
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Revision as of 18:26, 17 June 2016
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Hemophilia A Microchapters |
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Hemophilia A causes On the Web |
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American Roentgen Ray Society Images of Hemophilia A causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Causes
Hemophilia B is caused by an inherited X-linked recessive trait, with the defective gene located on the X chromosome.
Females have two copies of the X chromosome, so if the factor IX gene on one chromosome is defective, the gene on the other chromosome can do the job of making enough factor IX.
Males, however, have only one X chromosome, so if the factor IX gene on that chromosome is defective, they will have Hemophilia B. Therefore, most people with hemophilia B are male.
If a woman has a defective factor IX gene, she is considered a carrier. This means the defective gene can be passed down to her children.
Boys born to a woman who carries the defective gene have a 50% chance of having hemophilia B, while their daughters have a 50% chance of being a carrier.
All female children of men with hemophilia carry the defective gene.