Hemophilia A overview

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Hemophilia A is a blood clotting disorder caused by a mutation of the factor VIII gene, leading to a deficiency in Factor VIII. It is the most common hemophilia. Inheritance is X-linked recessive; hence, males are affected while females are carriers or very rarely display a mild phenotype. 1 in 5,000 males are affected.

References

1. History of Bleeding Disorders | National Hemophilia Foundation. Available at . Accessed on July 30, 2016
2. How is Hemophilia Diagnosed? – NHLBI, NIH. Available at . Accessed on July 30, 2016
3. Severity of Hemophilia – World Federation of Hemophilia. Available at . Accessed on July 30,2016
4. Facts | Hemophilia | NCBDDD | CDC. Available at . Accessed on July 30,2016
5. Data & Statistics | Hemophilia | NCBDDD | CDC. Available at Accessed on July 30,2016
6. Handbook of Genetic Counseling/Hemophilia and Von Willebrand Disease – Wikibooks, open books for an open world. Available at Accessed on July 30,2016
7. Konkle BA, Josephson NC, Nakaya Fletcher S. Hemophilia A. 2000 Sep 21 [Updated 2014 Jun 5]. In: Pagon RA, Adam MP, Ardinger HH, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2016. Available from: