Uveitis laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Tarek Nafee, M.D. [2]

Overview

There are no diagnostic lab findings associated with uveitis. The presence of certain non-specific laboratory findings, in the presence of uveitis, may be suggestive of certain underlying causes.

Laboratory findings

There are no diagnostic lab findings associated with uveitis. The presence of certain non-specific laboratory findings, in the presence of uveitis, may be suggestive of certain underlying causes such as:

Complete Blood Count with Differentials and Peripheral Blood Smear

• A low hemoglobin or hematocrit with microcytosis or marginal normocytosis may be indicative of blood loss by inflammatory bowel disease, or any chronic inflammatory disorder.
• Eosinophilia may be suggestive of underlying parasitic infections, or sarcoidosis.
• Elevated white blood cells with a left shift may be suggestive of an underlying infection.
• Decreased white blood cell count may be indicative of an immunosuppressed state.

ESR and CRP

• Elevated ESR and CRP may be suggestive of an underlying infection or inflammatory condition.

Iron studies

• Low ferritin with a high TIBC is suggestive of chronic blood loss by inflammatory bowel disease.
• High ferritin may be suggestive of anemia of chronic inflammatory conditions.

Complete Metabolic Panel

• Elevated BUN or Cr may be suggestive of renal dysfunction in tubulointerstitial nephritis with uveitis (TINU) syndrome.
• Liver function tests such as AST or ALT may be elevated if sarcoidosis, miliary tuberculosis, or Behcet's disease affect the liver

Serology tests

• HLA subtyping: HLA-B27, HLA-A29, HLA-B9, HLA-B15
• Antinuclear antibody (ANA)
• Anti-neutrophil cytoplasmic antibody (ANCA)
• Anti-dsDNA
• Venereal disease research laboratory (VDRL) or Rapid Plasma Reagin (RPR) for syphilis
• Purified protein derivative (PPD) for tuberculosis
• Lyme titer
• HIV test

Other Laboratory Findings

• Elevated levels of vitamin D or angiotensin converting enzyme (ACE) are suggestive of sarcoidosis

References

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