Hemophilia A overview: Difference between revisions

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Revision as of 23:23, 20 September 2016

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Fahd Yunus, M.D. [2]

Overview

Hemophilia A is a blood clotting disorder caused by a mutation of the factor VIII gene, leading to a deficiency in Factor VIII. It is the most common hemophilia. Inheritance is X-linked recessive; hence, males are affected while females are carriers or very rarely display a mild phenotype. 1 in 5,000 males are affected.

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating [Disease] from Other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications, and Prognosis

Natural History

Complications

Prognosis

Diagnosis

Diagnostic Criteria

History and Symptoms

Physical Examination

Laboratory Findings

Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Prevention

References

History of Bleeding Disorders | National Hemophilia Foundation. Available at . Accessed on July 30, 2016
How is Hemophilia Diagnosed? – NHLBI, NIH. Available at . Accessed on July 30, 2016
Severity of Hemophilia – World Federation of Hemophilia. Available at . Accessed on July 30,2016
Facts | Hemophilia | NCBDDD | CDC. Available at . Accessed on July 30,2016
Data & Statistics | Hemophilia | NCBDDD | CDC. Available at Accessed on July 30,2016
Handbook of Genetic Counseling/Hemophilia and Von Willebrand Disease – Wikibooks, open books for an open world. Available at Accessed on July 30,2016
Konkle BA, Josephson NC, Nakaya Fletcher S. Hemophilia A. 2000 Sep 21 [Updated 2014 Jun 5]. In: Pagon RA, Adam MP, Ardinger HH, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2016. Available from:http://www-ncbi-nlm-nih-gov.laneproxy.stanford.edu/books/NBK1404/

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 ==References==
 {{reflist|2}}
-<ref> History of Bleeding Disorders | National Hemophilia Foundation. Available at https://www.hemophilia.org/Bleeding-Disorders/History-of-Bleeding-Disorders . Accessed on July 30, 2016
+#History of Bleeding Disorders | National Hemophilia Foundation. Available at . Accessed on July 30, 2016
-<ref>How is Hemophilia Diagnosed? – NHLBI, NIH. Available at http://www.nhlbi.nih.gov/health/health-topics/topics/hemophilia/diagnosis. Accessed on July 30, 2016
+#How is Hemophilia Diagnosed? – NHLBI, NIH. Available at . Accessed on July 30, 2016
-<ref>Severity of Hemophilia – World Federation of Hemophilia. Available at http://www.wfh.org/en/page.aspx?pid=643. Accessed on July 30,2016 </ref>
+#Severity of Hemophilia – World Federation of Hemophilia. Available at . Accessed on July 30,2016
-<ref>Facts | Hemophilia | NCBDDD | CDC. Available at http://www.cdc.gov/ncbddd/hemophilia/facts.html
+#Facts | Hemophilia | NCBDDD | CDC. Available at . Accessed on July 30,2016
- Accessed on July 30,2016
+#Data & Statistics | Hemophilia | NCBDDD | CDC. Available at  Accessed on July 30,2016
-<ref>Data & Statistics | Hemophilia | NCBDDD | CDC. Available at http://www.cdc.gov/ncbddd/hemophilia/data.html Accessed on July 30,2016
+#Handbook of Genetic Counseling/Hemophilia and Von Willebrand Disease – Wikibooks, open books for an open world. Available at  Accessed on July 30,2016
-<ref>Handbook of Genetic Counseling/Hemophilia and Von Willebrand Disease – Wikibooks, open books for an open world. Available at https://en.wikibooks.org/wiki/Handbook_of_Genetic_Counseling/Hemophilia_and_Von_Willebrand_Disease Accessed on July 30,2016
+#Konkle BA, Josephson NC, Nakaya Fletcher S. Hemophilia A. 2000 Sep 21 [Updated 2014 Jun 5]. In: Pagon RA, Adam MP, Ardinger HH, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2016. Available from:http://www-ncbi-nlm-nih-gov.laneproxy.stanford.edu/books/NBK1404/
-<ref> Konkle BA, Josephson NC, Nakaya Fletcher S. Hemophilia A. 2000 Sep 21 [Updated 2014 Jun 5]. In: Pagon RA, Adam MP, Ardinger HH, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2016. Available from: http://www-ncbi-nlm-nih-gov.laneproxy.stanford.edu/books/NBK1404/