Lymphangitis pathophysiology: Difference between revisions
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{{Lymphangitis}} | {{Lymphangitis}} | ||
{{CMG}}; {{AE}} {{VR}} | {{CMG}}; {{AE}} {{VR}}{{VD}} | ||
==Overview== | ==Overview== | ||
Revision as of 16:20, 10 October 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vendhan Ramanujam M.B.B.S [2]Vishal Devarkonda, M.B.B.S[3]
Overview
Lymphangitis is inflammation of the lymphatic system, a system that is comprised of small vessels of the immune system that carry lymphatic fluid. The fluid is filtered in the lymph nodes and spleen, drained into the subclavian veins and finally returned back to the circulatory system.
Pathophysiology
- Lymphatic vessels are thin walled, valved structures situated in deep dermis and sub-dermis tissues.[1]
- Lymph follows the following pattern of drainage.
- Lymph from tissues drain into the regional lymph nodes via afferent lymphatics, then to right lymphatic duct and thoracic duct via efferent lymphatics, and finally into the venous circulation via one of the subclavian veins.
Settings involved in pathogenesis of disease are
- Normal Lymphatic vessels:- Invasion of microorganisms either from a traumatized skin or from a distal site of infection into the lymphatic vessels that leads to inflammation of the vessel
- Anatomical abnormalities resulting in obstruction of lymphatic channels or damage to the lymphatic vessels as seen in setting of surgery, malignancy, and trauma.[2]
References
- ↑ Suami H, Taylor GI, Pan WR (2007). "The lymphatic territories of the upper limb: anatomical study and clinical implications". Plast Reconstr Surg. 119 (6): 1813–22. doi:10.1097/01.prs.0000246516.64780.61. PMID 17440362.
- ↑ Simon MS, Cody RL (1992). "Cellulitis after axillary lymph node dissection for carcinoma of the breast". Am J Med. 93 (5): 543–8. PMID 1364813.