Goodpasture syndrome history and symptoms: Difference between revisions

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Revision as of 16:33, 14 November 2016

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2]Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3]

Overview

Obtaining a complete history is an important aspect of making a diagnosis of Goodpasture syndrome, as it can provide insight into cause, precipitating factors, and associated underlying conditions. Symptoms may develop acutely or rapidly affecting the renal and pulmonary system. Symptoms of Goodpasture syndrome include, malaise, pyrexia and chills and arthralgia, fatigue, lethargy, pallor, and anorexia.^[1]

History and Symptoms

Symptoms may occur very slowly over months or even years, but they often develop quickly over days to weeks.

Loss of appetite, fatigue, weakness are often seen at first.^[1] ^[2]

Pulmonary symptoms may include:^[1]

Hemoptysis
Dry cough
Dyspnea
Anemia
Pulmonary hemorrhage that may lead to respiratory failure
less frequently may cause angina pectoris

Renal and other symptoms include:^[1]

Dysuria
Hematuria
Edema of the hands and feet
Uremia
Hypertension
Back pain below the ribs
Hearing loss
Vertigo

References

↑ ^1.0 ^1.1 ^1.2 ^1.3 Greco A, Rizzo MI, De Virgilio A, Gallo A, Fusconi M, Pagliuca G; et al. (2015). "Goodpasture's syndrome: a clinical update". Autoimmun Rev. 14 (3): 246–53. doi:10.1016/j.autrev.2014.11.006. PMID 25462583.
↑ Hellmark T, Segelmark M (2014). "Diagnosis and classification of Goodpasture's disease (anti-GBM)". J Autoimmun. 48-49: 108–12. doi:10.1016/j.jaut.2014.01.024. PMID 24456936.

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[pmid25462583-1] 1.0 ^1.1 ^1.2 ^1.3 Greco A, Rizzo MI, De Virgilio A, Gallo A, Fusconi M, Pagliuca G; et al. (2015). "Goodpasture's syndrome: a clinical update". Autoimmun Rev. 14 (3): 246–53. doi:10.1016/j.autrev.2014.11.006. PMID 25462583.

[pmid24456936-2] Hellmark T, Segelmark M (2014). "Diagnosis and classification of Goodpasture's disease (anti-GBM)". J Autoimmun. 48-49: 108–12. doi:10.1016/j.jaut.2014.01.024. PMID 24456936.

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[2]

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 * Hearing loss
 * Vertigo
-=== Lung disease ===
-Lung damage may cause nothing more serious than a dry [[cough]] and minor [[breathlessness]] and such mild symptoms may last for many years before more severe ones develop. At its most serious, however, lung damage may cause severe impairment of oxygenation so that intensive care is required. Deterioration between the two extremes may occur very rapidly, often at the same time as rapid deterioration in the kidney. The patient often does not seek medical attention until he or she begins coughing up blood ([[hemoptysis]]). The patient may be [[anemia|anemic]] due to loss of blood through lung haemorrhaging over a long period. In Goodpasture’s syndrome, unlike many other conditions that cause similar symptoms, lung hemorrhaging most often occurs in [[tobacco smoking|smokers]] and those with damage from lung [[infectious disease|infection]] or exposure to fumes.
-=== Kidney disease ===
-The kidney disease mostly affects the [[glomerulus|glomeruli]] causing a form of [[nephritis]]. It is usually not detected until a rapid advance of the disease occurs so that kidney function can be completely lost in a matter of days, a condition known as rapidly progressive glomerulonephritis, or RPGN. [[Blood]] leaks into the [[urine]] causing [[hematuria|hematuria]], the volume urinated decreases and [[urea]] and other products usually excreted by the kidney are retained and build up in the blood. This is [[acute renal failure]]. Renal failure does not cause symptoms until more than 80% of kidney function has been lost. Symptoms include loss of appetite and sickness at first and then, when the damage is more advanced, breathlessness, high [[blood pressure]] and [[edema]] (swelling caused by fluid retention).  The kidney involvement usually presents as [[nephritic syndrome]], i.e. hematuria, a reduced [[glomerular filtration rate]], and high blood pressure.  This is in contrast to [[nephrotic syndrome]], a more rare outcome of Goodpasture's, characterized by an abnormally large amount protein in the urine (proteinuria), coupled with severe edema.
 ==References==

Goodpasture syndrome history and symptoms: Difference between revisions

Revision as of 16:33, 14 November 2016

Overview

History and Symptoms

References

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