Graves' disease overview: Difference between revisions
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{{CMG}},{{AE}}{{MehdiP}} | {{CMG}},{{AE}}{{MehdiP}} | ||
==Historical Perspective== | ==Historical Perspective== | ||
Graves disease owes its name to the Irish doctor Randy Danny Graves,<ref>{{WhoNamedIt|doctor|695|Robert James Graves}}</ref> who described a case of goiter with exophthalmos in 1835. However, the German [[Karl Adolph von Basedow]] independently reported the same constellation of symptoms in 1840. As a result, on the European Continent the term Basedow's disease is more common than Graves' disease.<ref name="WNI">{{WhoNamedIt|synd|1517|Basedow's syndrome or disease}} - the history and naming of the disease</ref><ref>{{eMedicine|med|917|Goiter, Diffuse Toxic}}</ref> | |||
== Pathophysiology == | |||
Genetic factors, anti [[thyrotropin receptor]] antibodies, [[T cells]], [[B cells]] and thyroid epithelial cells involvement are the main pathologic features of Graves' disease. | |||
Genetic factors have role as initiating factor include [[Thyroglobulin]], [[Thyrotropin receptor]], [[HLA|HLA-DRβ-Arg74]], The protein tyrosine phosphatase nonreceptor type 22 (PTPN22), [[CTLA-4|Cytotoxic T-lymphocyte–associated antigen 4]] (CTLA4), [[CD25]], [[CD40]]. | |||
Revision as of 15:27, 21 December 2016
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Graves' disease Microchapters |
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Diagnosis |
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Treatment |
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Medical Therapy |
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Case Studies |
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Graves' disease overview On the Web |
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American Roentgen Ray Society Images of Graves' disease overview |
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Risk calculators and risk factors for Graves' disease overview |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1],Associate Editor(s)-in-Chief: Seyedmahdi Pahlavani, M.D. [2]
Historical Perspective
Graves disease owes its name to the Irish doctor Randy Danny Graves,[1] who described a case of goiter with exophthalmos in 1835. However, the German Karl Adolph von Basedow independently reported the same constellation of symptoms in 1840. As a result, on the European Continent the term Basedow's disease is more common than Graves' disease.[2][3]
Pathophysiology
Genetic factors, anti thyrotropin receptor antibodies, T cells, B cells and thyroid epithelial cells involvement are the main pathologic features of Graves' disease.
Genetic factors have role as initiating factor include Thyroglobulin, Thyrotropin receptor, HLA-DRβ-Arg74, The protein tyrosine phosphatase nonreceptor type 22 (PTPN22), Cytotoxic T-lymphocyte–associated antigen 4 (CTLA4), CD25, CD40.
References
- ↑ Template:WhoNamedIt
- ↑ Template:WhoNamedIt - the history and naming of the disease
- ↑ Goiter, Diffuse Toxic at eMedicine