Hemophilia A causes: Difference between revisions
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{{Hemophilia A}} | {{Hemophilia A}} | ||
{{CMG}} | {{CMG}}{{FNY}} | ||
==Overview== | ==Overview== | ||
[[Hemophilia A]] is caused by an inherited [[X-linked]] [[recessive trait]], with the defective [[gene]] located on the [[X chromosome]]. | |||
==Causes== | ==Causes== | ||
Females have two copies of the [[X chromosome]], so if the [[factor VIII]] [[gene]] on one [[chromosome]] is defective, the [[gene]] on the other [[chromosome]] can do the job of making enough [[factor VIII]]. | |||
Females have two copies of the [[X chromosome]], so if the [[factor | |||
Males, however, have only one [[X chromosome]], so if the [[factor | Males, however, have only one [[X chromosome]], so if the [[factor VIII]] [[gene]] on that [[chromosome]] is defective, they will have [[Hemophilia A]]. Therefore, most people with [[hemophilia A]] are male. | ||
If a woman has a defective [[factor | If a woman has a defective [[factor VIII]] [[gene]], she is considered a carrier. This means the defective [[gene]] can be passed down to her children. | ||
Boys born to a woman who carries the defective [[gene]] have a 50% chance of having [[hemophilia | Boys born to a woman who carries the defective [[gene]] have a 50% chance of having [[hemophilia A]], while their daughters have a 50% chance of being a carrier. | ||
All female children of men with [[hemophilia]] carry the defective [[gene]]. | All female children of men with [[hemophilia A]] carry the defective [[gene]]. | ||
==References== | ==References== | ||
Revision as of 07:10, 27 March 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Fahd Yunus, M.D. [2]
Overview
Hemophilia A is caused by an inherited X-linked recessive trait, with the defective gene located on the X chromosome.
Causes
Females have two copies of the X chromosome, so if the factor VIII gene on one chromosome is defective, the gene on the other chromosome can do the job of making enough factor VIII.
Males, however, have only one X chromosome, so if the factor VIII gene on that chromosome is defective, they will have Hemophilia A. Therefore, most people with hemophilia A are male.
If a woman has a defective factor VIII gene, she is considered a carrier. This means the defective gene can be passed down to her children.
Boys born to a woman who carries the defective gene have a 50% chance of having hemophilia A, while their daughters have a 50% chance of being a carrier.
All female children of men with hemophilia A carry the defective gene.