Hemophilia A laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
The diagnosis of [[Hemophilia A]] may be suspected as [[coagulation]] testing reveals an increased [[partial thromboplastin time|PTT]] in the context of a normal [[prothrombin time|PT]] and [[bleeding time]]. The diagnosis is made in the presence of very low (<10 IU) levels of [[factor VIII]]. | The diagnosis of [[Hemophilia A]] may be suspected as [[coagulation]] testing reveals an increased [[partial thromboplastin time|PTT]] in the context of a normal [[prothrombin time|PT]] and [[bleeding time]]. <ref name="pmid25356200">{{cite journal| author=Cortegiani A, Russotto V, Foresta G, Montalto F, Strano MT, Raineri SM et al.| title=A perioperative uncontrollable bleeding in an elderly patient with acquired hemophilia A: a case report. | journal=Clin Case Rep | year= 2013 | volume= 1 | issue= 1 | pages= 3-6 | pmid=25356200 | doi=10.1002/ccr3.2 | pmc=4184532 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25356200 }} </ref> The diagnosis is made in the presence of very low (<10 IU) levels of [[factor VIII]]. | ||
A very small minority of patients has [[antibodies]] against factor VIII that impair its functioning. Management of these patients is more complicated. <ref>Handbook of Genetic Counseling/Hemophilia and Von Willebrand Disease – Wikibooks, open books for an open world. Available at https://en.wikibooks.org/wiki/Handbook_of_Genetic_Counseling/Hemophilia_and_Von_Willebrand_Disease Accessed on July 30,2016 </ref> | A very small minority of patients has [[antibodies]] against factor VIII that impair its functioning. Management of these patients is more complicated. <ref>Handbook of Genetic Counseling/Hemophilia and Von Willebrand Disease – Wikibooks, open books for an open world. Available at https://en.wikibooks.org/wiki/Handbook_of_Genetic_Counseling/Hemophilia_and_Von_Willebrand_Disease Accessed on July 30,2016 </ref> | ||
Revision as of 05:38, 16 April 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Fahd Yunus, M.D. [2]
Overview
The diagnosis of Hemophilia A may be suspected as coagulation testing reveals an increased PTT in the context of a normal PT and bleeding time. [1] The diagnosis is made in the presence of very low (<10 IU) levels of factor VIII. A very small minority of patients has antibodies against factor VIII that impair its functioning. Management of these patients is more complicated. [2]
Laboratory Findings
The typical coagulation profile of a patient with hemophilia A usually presents as the following: [3]
- Prolonged partial thromboplastin time (PTT)
- Normal prothrombin time
- Normal bleeding time
- Normal fibrinogen level
- Low factor VIII
Other laboratory findings consistent with the diagnosis of hemophilia A include correction of the PTT with a 1:1 mixing study (i.e. factor VIII from the normal blood mixed with the hemophiliac blood is able to correct for the coagulation deficit)
References
- ↑ Cortegiani A, Russotto V, Foresta G, Montalto F, Strano MT, Raineri SM; et al. (2013). "A perioperative uncontrollable bleeding in an elderly patient with acquired hemophilia A: a case report". Clin Case Rep. 1 (1): 3–6. doi:10.1002/ccr3.2. PMC 4184532. PMID 25356200.
- ↑ Handbook of Genetic Counseling/Hemophilia and Von Willebrand Disease – Wikibooks, open books for an open world. Available at https://en.wikibooks.org/wiki/Handbook_of_Genetic_Counseling/Hemophilia_and_Von_Willebrand_Disease Accessed on July 30,2016
- ↑ Diagnosis | Hemophilia | NCBDDD | CDC. Available at http://www.cdc.gov/ncbddd/hemophilia/diagnosis.html. Accessed on Sept 20, 2016