Postpartum thyroiditis natural history, complications and prognosis: Difference between revisions
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==Overview== | ==Overview== | ||
Prognosis is generally good, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%. | |||
Prognosis is generally | |||
==Natural History, Complications, and Prognosis== | ==Natural History, Complications, and Prognosis== | ||
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*Biphasic hypothyroidism: 43 % patients of PPT develops symptoms of hypothyroidism followed recovery .<ref name="pmid22312089">{{cite journal| author=Stagnaro-Green A| title=Approach to the patient with postpartum thyroiditis. | journal=J Clin Endocrinol Metab | year= 2012 | volume= 97 | issue= 2 | pages= 334-42 | pmid=22312089 | doi=10.1210/jc.2011-2576 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22312089 }} </ref> | *Biphasic hypothyroidism: 43 % patients of PPT develops symptoms of hypothyroidism followed recovery .<ref name="pmid22312089">{{cite journal| author=Stagnaro-Green A| title=Approach to the patient with postpartum thyroiditis. | journal=J Clin Endocrinol Metab | year= 2012 | volume= 97 | issue= 2 | pages= 334-42 | pmid=22312089 | doi=10.1210/jc.2011-2576 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22312089 }} </ref> | ||
*If left untreated, 25-30% of patients with PPT may progress to develop hypothyroidism<ref name="pmid10634366">{{cite journal| author=Premawardhana LD, Parkes AB, Ammari F, John R, Darke C, Adams H et al.| title=Postpartum thyroiditis and long-term thyroid status: prognostic influence of thyroid peroxidase antibodies and ultrasound echogenicity. | journal=J Clin Endocrinol Metab | year= 2000 | volume= 85 | issue= 1 | pages= 71-5 | pmid=10634366 | doi=10.1210/jcem.85.1.6227 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10634366 }} </ref> | *If left untreated, 25-30% of patients with PPT may progress to develop hypothyroidism<ref name="pmid10634366">{{cite journal| author=Premawardhana LD, Parkes AB, Ammari F, John R, Darke C, Adams H et al.| title=Postpartum thyroiditis and long-term thyroid status: prognostic influence of thyroid peroxidase antibodies and ultrasound echogenicity. | journal=J Clin Endocrinol Metab | year= 2000 | volume= 85 | issue= 1 | pages= 71-5 | pmid=10634366 | doi=10.1210/jcem.85.1.6227 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10634366 }} </ref> | ||
*Patients who are anti-TPO antibodies positive,HLA-DRW9 and/or - | *Patients who are anti-TPO antibodies positive,HLA-DRW9 and/or HLA-DRB51 <ref name="pmid3162458">{{cite journal| author=Tachi J, Amino N, Tamaki H, Aozasa M, Iwatani Y, Miyai K| title=Long term follow-up and HLA association in patients with postpartum hypothyroidism. | journal=J Clin Endocrinol Metab | year= 1988 | volume= 66 | issue= 3 | pages= 480-4 | pmid=3162458 | doi=10.1210/jcem-66-3-480 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3162458 }} </ref> , and developed hypothyroid phase of PPT, are at increased risk of developing permanent hypothyroidism.<ref name="StuckeyKent2010">{{cite journal|last1=Stuckey|first1=B G A|last2=Kent|first2=G N|last3=Ward|first3=L C|last4=Brown|first4=S J|last5=Walsh|first5=J P|title=ORIGINAL ARTICLE: Postpartum thyroid dysfunction and the long-term risk of hypothyroidism: results from a 12-year follow-up study of women with and without postpartum thyroid dysfunction|journal=Clinical Endocrinology|volume=73|issue=3|year=2010|pages=389–395|issn=03000664|doi=10.1111/j.1365-2265.2010.03797.x}}</ref> | ||
===Complications=== | ===Complications=== | ||
*Common complications of | *Common complications of include: | ||
** | **Hypothyroidism | ||
** | **Postpartum depression | ||
===Prognosis=== | ===Prognosis=== | ||
Revision as of 23:46, 29 September 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Prognosis is generally good, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
Natural History, Complications, and Prognosis
Natural History
- The symptoms of postpartum thyroiditis, PPT usually develop in the twevle months after devilry , abortion or miscarriage of fetus and start with symptoms depending on clinical course that it follows.
- There are three clinical courses:
- Classic triphasic: 25% of patients of PPT come to clinical attention with symptoms of hyperthyroidism followed by hypothyroidism and then euthyroidisum.[1]
- Biphasic hyperthyroidism: 32 % patients of PPT develops symptoms of hyperthyroidism followed recovery.[1]
- Biphasic hypothyroidism: 43 % patients of PPT develops symptoms of hypothyroidism followed recovery .[1]
- If left untreated, 25-30% of patients with PPT may progress to develop hypothyroidism[2]
- Patients who are anti-TPO antibodies positive,HLA-DRW9 and/or HLA-DRB51 [3] , and developed hypothyroid phase of PPT, are at increased risk of developing permanent hypothyroidism.[4]
Complications
- Common complications of include:
- Hypothyroidism
- Postpartum depression
Prognosis
- Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
- Depending on the extent of the [tumor/disease progression/etc.] at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent.
- The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with [disease/malignancy].
- [Subtype of disease/malignancy] is associated with the most favorable prognosis.
- The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis.
References
- ↑ 1.0 1.1 1.2 Stagnaro-Green A (2012). "Approach to the patient with postpartum thyroiditis". J Clin Endocrinol Metab. 97 (2): 334–42. doi:10.1210/jc.2011-2576. PMID 22312089.
- ↑ Premawardhana LD, Parkes AB, Ammari F, John R, Darke C, Adams H; et al. (2000). "Postpartum thyroiditis and long-term thyroid status: prognostic influence of thyroid peroxidase antibodies and ultrasound echogenicity". J Clin Endocrinol Metab. 85 (1): 71–5. doi:10.1210/jcem.85.1.6227. PMID 10634366.
- ↑ Tachi J, Amino N, Tamaki H, Aozasa M, Iwatani Y, Miyai K (1988). "Long term follow-up and HLA association in patients with postpartum hypothyroidism". J Clin Endocrinol Metab. 66 (3): 480–4. doi:10.1210/jcem-66-3-480. PMID 3162458.
- ↑ Stuckey, B G A; Kent, G N; Ward, L C; Brown, S J; Walsh, J P (2010). "ORIGINAL ARTICLE: Postpartum thyroid dysfunction and the long-term risk of hypothyroidism: results from a 12-year follow-up study of women with and without postpartum thyroid dysfunction". Clinical Endocrinology. 73 (3): 389–395. doi:10.1111/j.1365-2265.2010.03797.x. ISSN 0300-0664.