Differentiating Cretinism from other diseases: Difference between revisions
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*Symptoms, if present, may include, but not limited to: | *Symptoms, if present, may include, but not limited to: | ||
**[[Macroglossia]] | **[[Macroglossia]] | ||
**Hoarse cry | **[[Hoarse]] cry | ||
**[[Umbilical hernia]] | **[[Umbilical hernia]] | ||
**Puffy facies | **Puffy facies | ||
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* Transient [[intestinal obstruction]] for 1-2 days after birth. | * Transient [[intestinal obstruction]] for 1-2 days after birth. | ||
* Obstruction is functional due to dilated colon and delayed passage of feces. | * Obstruction is functional due to dilated colon and delayed passage of [[feces]]. | ||
* Usually seen in [[premature infants]].<ref name="pmid18485962">{{cite journal |vauthors=Keckler SJ, St Peter SD, Spilde TL, Tsao K, Ostlie DJ, Holcomb GW, Snyder CL |title=Current significance of meconium plug syndrome |journal=J. Pediatr. Surg. |volume=43 |issue=5 |pages=896–8 |year=2008 |pmid=18485962 |pmc=3086204 |doi=10.1016/j.jpedsurg.2007.12.035 |url=}}</ref> | * Usually seen in [[premature infants]].<ref name="pmid18485962">{{cite journal |vauthors=Keckler SJ, St Peter SD, Spilde TL, Tsao K, Ostlie DJ, Holcomb GW, Snyder CL |title=Current significance of meconium plug syndrome |journal=J. Pediatr. Surg. |volume=43 |issue=5 |pages=896–8 |year=2008 |pmid=18485962 |pmc=3086204 |doi=10.1016/j.jpedsurg.2007.12.035 |url=}}</ref> | ||
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|[[Intestinal atresia|Distal small intestine/colon atresia]] | |[[Intestinal atresia|Distal small intestine/colon atresia]] | ||
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* Failure to pass [[meconium]] due to failure of intestine recanalization. | * Failure to pass [[meconium]] due to failure of [[intestine]] recanalization. | ||
* Proximal [[lesions]] have an earlier onset of symptoms than distal [[lesions]]. | * Proximal [[lesions]] have an earlier onset of symptoms than distal [[lesions]]. | ||
* [[Intestinal atresia|Colonic atresia]] may affect normal children or may be associated with other abnormalities as Hirschsprung's disease or [[gastroschisis]].<ref name="pmid17077911">{{cite journal |vauthors=Spitz L |title=Observations on the origin of congenital intestinal atresia |journal=S. Afr. Med. J. |volume=96 |issue=9 Pt 2 |pages=864 |year=2006 |pmid=17077911 |doi= |url=}}</ref> | * [[Intestinal atresia|Colonic atresia]] may affect normal children or may be associated with other abnormalities as [[Hirschsprung's disease]] or [[gastroschisis]].<ref name="pmid17077911">{{cite journal |vauthors=Spitz L |title=Observations on the origin of congenital intestinal atresia |journal=S. Afr. Med. J. |volume=96 |issue=9 Pt 2 |pages=864 |year=2006 |pmid=17077911 |doi= |url=}}</ref> | ||
|[[Image:Small-bowel-atresia - Case courtesy of A.Prof Frank Gaillard, Radiopaedia.org, rID 5959.jpg|center|300px|thumb|Normal appearing colon that is small and unused. Contrast fills the whole colon and passes to the ileum - Case courtesy of A.Prof Frank Gaillard, Radiopaedia.org, rID 5959]] | |[[Image:Small-bowel-atresia - Case courtesy of A.Prof Frank Gaillard, Radiopaedia.org, rID 5959.jpg|center|300px|thumb|Normal appearing colon that is small and unused. Contrast fills the whole colon and passes to the ileum - Case courtesy of A.Prof Frank Gaillard, Radiopaedia.org, rID 5959]] | ||
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|[[Meconium ileus]] | |[[Meconium ileus]] | ||
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* [[Intestinal obstruction]] due to inspissation of [[meconium]] in the [[Ileum|distal ileum]]. | * [[Intestinal obstruction]] due to [[inspissation]] of [[meconium]] in the [[Ileum|distal ileum]]. | ||
* Most cases of [[meconium ileus]] are secondary to [[cystic fibrosis]]. | * Most cases of [[meconium ileus]] are secondary to [[cystic fibrosis]]. | ||
* Typically presents with failure to pass [[meconium]] and [[abdominal distension]] with or without [[vomiting]]. | * Typically presents with failure to pass [[meconium]] and [[abdominal distension]] with or without [[vomiting]]. | ||
Revision as of 15:10, 27 October 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]
Overview
Cretinism must be differentiated from other diseases that cause a failure to pass meconium or abdominal distension in infants, including meconium plug syndrome, small left colon syndrome, and Hirschsprung's disease.
Differentiating cretinism from other Diseases
Cretinism must be differentiated from other diseases that cause a failure to pass meconium or abdominal distension in infants, including meconium plug syndrome, small left colon syndrome, and Hirschsprung's disease.
| Disease | Prominent clinical features | Radiological findings |
|---|---|---|
| Cretinism (Congenital hypothyroidism) |
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| Meconium plug syndrome |
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| Small left colon syndrome |
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| Distal small intestine/colon atresia |
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| Meconium ileus |
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References
- ↑ "Elementary school performance of children with congenital hypothyroidism. New England Congenital Hypothyroidism Collaborative". J. Pediatr. 116 (1): 27–32. 1990. PMID 2295961.
- ↑ Keckler SJ, St Peter SD, Spilde TL, Tsao K, Ostlie DJ, Holcomb GW, Snyder CL (2008). "Current significance of meconium plug syndrome". J. Pediatr. Surg. 43 (5): 896–8. doi:10.1016/j.jpedsurg.2007.12.035. PMC 3086204. PMID 18485962.
- ↑ Berdon WE, Slovis TL, Campbell JB, Baker DH, Haller JO (1977). "Neonatal small left colon syndrome: its relationship with aganglionosis and meconium plug syndrome". Radiology. 125 (2): 457–62. doi:10.1148/125.2.457. PMID 910057.
- ↑ Spitz L (2006). "Observations on the origin of congenital intestinal atresia". S. Afr. Med. J. 96 (9 Pt 2): 864. PMID 17077911.
- ↑ HOLSCLAW DS, ECKSTEIN HB, NIXON HH (1965). "MECONIUM ILEUS. A 20-YEAR REVIEW OF 109 CASES". Am. J. Dis. Child. 109: 101–13. PMID 14237408.