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==Overview==
==Overview==
'''Wilson's disease''' or '''hepatolenticular degeneration''' is an [[autosomal recessive]] [[genetic disorder]] in which [[copper]] accumulates in [[biological tissue|tissues]]; this manifests as [[neurology|neurological]] or [[psychiatry|psychiatric]] symptoms and [[liver]] disease. It is treated with [[medication]] that reduces copper absorption or removes the excess copper from the body, but occasionally a [[liver transplantation|liver transplant]] is required.


The condition is due to [[mutation]]s in the [[Wilson disease protein]] (ATP7B) [[gene]]. A single abnormal copy of the gene is present in 1 in 100 people, who do not develop any symptoms (they are [[Genetic carrier|carrier]]s). If a child inherits the gene from both parents, they may develop Wilson's disease. Symptoms usually appear between the ages of 6 and 20 years, but cases in much older patients have been described. Wilson's disease occurs in 1 to 4 per 100,000 people.
==Historical Perspective==
 
==Classification==
 
==Pathophysiology==
 
==Causes==
 
==Differentiating ((Page name)) from Other Diseases==
 
==Epidemiology and Demographics==
 
==Risk Factors==
 
==Screening==
 
==Natural History, Complications, and Prognosis==
 
 
==Diagnosis==
===Diagnostic Criteria===
 
===History and Symptoms===
 
===Physical Examination===
 
===Laboratory Findings===
 
===Electrocardiogram===
 
===X-ray===
 
===Ultrasound===
 
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===Other Imaging Findings===
 
===Other Diagnostic Studies===
 
==Treatment==
===Medical Therapy===
 
===Surgery===
 
===Primary Prevention===
 
===Secondary Prevention===
 
==References==
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==References==
==References==

Revision as of 14:14, 12 December 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]; Associate Editor(s)-in-Chief:

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating ((Page name)) from Other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications, and Prognosis

Diagnosis

Diagnostic Criteria

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Ultrasound

CT scan

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

References


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