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{{Infobox_gene}}
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'''Insulin receptor-related protein''' is a [[protein]] that in humans is encoded by the ''INSRR'' [[gene]].<ref name="pmid2768234">{{cite journal |vauthors=Shier P, Watt VM | title = Primary structure of a putative receptor for a ligand of the insulin family | journal = J Biol Chem | volume = 264 | issue = 25 | pages = 14605–8 |date=Oct 1989 | pmid = 2768234 | pmc =  | doi =  }}</ref><ref name="pmid2249481">{{cite journal |vauthors=Shier P, Willard HF, Watt VM | title = Localization of the insulin receptor-related receptor gene to human chromosome 1 | journal = Cytogenet Cell Genet | volume = 54 | issue = 1–2 | pages = 80–1 |date=Jan 1991 | pmid = 2249481 | pmc =  | doi =10.1159/000132963 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: INSRR insulin receptor-related receptor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3645| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Insulin receptor-related receptor
| HGNCid = 6093
| Symbol = INSRR
| AltSymbols =; IRR
| OMIM = 147671
| ECnumber =
| Homologene = 56539
| MGIid = 1346037
  | GeneAtlas_image1 = PBB_GE_INSRR_215776_at_tn.png
  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005006 |text = epidermal growth factor receptor activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007169 |text = transmembrane receptor protein tyrosine kinase signaling pathway}} {{GNF_GO|id=GO:0030238 |text = male sex determination}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3645
    | Hs_Ensembl = ENSG00000027644
    | Hs_RefseqProtein = NP_055030
    | Hs_RefseqmRNA = NM_014215
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 155076479
    | Hs_GenLoc_end = 155095434
    | Hs_Uniprot = P14616
    | Mm_EntrezGene = 23920
    | Mm_Ensembl = ENSMUSG00000005640
    | Mm_RefseqmRNA = NM_011832
    | Mm_RefseqProtein = NP_035962
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 87882989
    | Mm_GenLoc_end = 87902028
    | Mm_Uniprot = Q3UQC8
  }}
}}
'''Insulin receptor-related receptor''', also known as '''INSRR''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: INSRR insulin receptor-related receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3645| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Zhang B, Roth RA |title=The insulin receptor-related receptor. Tissue expression, ligand binding specificity, and signaling capabilities. |journal=J. Biol. Chem. |volume=267 |issue= 26 |pages= 18320-8 |year= 1992 |pmid= 1326521 |doi=  }}
*{{cite journal  |vauthors=Zhang B, Roth RA |title=The insulin receptor-related receptor. Tissue expression, ligand binding specificity, and signaling capabilities |journal=J. Biol. Chem. |volume=267 |issue= 26 |pages= 18320–8 |year= 1992 |pmid= 1326521 |doi=  }}
*{{cite journal  | author=Shier P, Willard HF, Watt VM |title=Localization of the insulin receptor-related receptor gene to human chromosome 1. |journal=Cytogenet. Cell Genet. |volume=54 |issue= 1-2 |pages= 80-1 |year= 1991 |pmid= 2249481 |doi=  }}
*{{cite journal  |vauthors=Mathi SK, Chan J, Watt VM |title=Insulin receptor-related receptor messenger ribonucleic acid: quantitative distribution and localization to subpopulations of epithelial cells in stomach and kidney |journal=Endocrinology |volume=136 |issue= 9 |pages= 4125–32 |year= 1995 |pmid= 7649121 |doi=10.1210/en.136.9.4125 }}
*{{cite journal  | author=Shier P, Watt VM |title=Primary structure of a putative receptor for a ligand of the insulin family. |journal=J. Biol. Chem. |volume=264 |issue= 25 |pages= 14605-8 |year= 1989 |pmid= 2768234 |doi=  }}
*{{cite journal  |vauthors=Kovacina KS, Roth RA |title=Characterization of the endogenous insulin receptor-related receptor in neuroblastomas |journal=J. Biol. Chem. |volume=270 |issue= 4 |pages= 1881–7 |year= 1995 |pmid= 7829525 |doi=10.1074/jbc.270.4.1881 }}
*{{cite journal  | author=Mathi SK, Chan J, Watt VM |title=Insulin receptor-related receptor messenger ribonucleic acid: quantitative distribution and localization to subpopulations of epithelial cells in stomach and kidney. |journal=Endocrinology |volume=136 |issue= 9 |pages= 4125-32 |year= 1995 |pmid= 7649121 |doi=  }}
*{{cite journal  |vauthors=Jui HY, Accili D, Taylor SI |title=Characterization of a hybrid receptor formed by dimerization of the insulin receptor-related receptor (IRR) with the insulin receptor (IR): coexpression of cDNAs encoding human IRR and human IR in NIH-3T3 cells |journal=Biochemistry |volume=35 |issue= 45 |pages= 14326–30 |year= 1996 |pmid= 8916919 |doi= 10.1021/bi9613032 }}
*{{cite journal  | author=Kovacina KS, Roth RA |title=Characterization of the endogenous insulin receptor-related receptor in neuroblastomas. |journal=J. Biol. Chem. |volume=270 |issue= 4 |pages= 1881-7 |year= 1995 |pmid= 7829525 |doi=  }}
*{{cite journal  | author=Hänze J |title=Cloning and sequencing of the complete cDNA encoding the human insulin receptor related receptor |journal=Horm. Metab. Res. |volume=31 |issue= 2–3 |pages= 77–9 |year= 1999 |pmid= 10226785 |doi=10.1055/s-2007-978702  |name-list-format=vanc| author2=Berthold A  | author3=Klammt J  | display-authors=3  | last4=Gallaher  | first4=B.  | last5=Siebler  | first5=T.  | last6=Kratzsch  | first6=J.  | last7=Elmlinger  | first7=M.  | last8=Kiess  | first8=W. }}
*{{cite journal  | author=Jui HY, Accili D, Taylor SI |title=Characterization of a hybrid receptor formed by dimerization of the insulin receptor-related receptor (IRR) with the insulin receptor (IR): coexpression of cDNAs encoding human IRR and human IR in NIH-3T3 cells. |journal=Biochemistry |volume=35 |issue= 45 |pages= 14326-30 |year= 1996 |pmid= 8916919 |doi= 10.1021/bi9613032 }}
*{{cite journal  |vauthors=Xu P, Jacobs AR, Taylor SI |title=Interaction of insulin receptor substrate 3 with insulin receptor, insulin receptor-related receptor, insulin-like growth factor-1 receptor, and downstream signaling proteins |journal=J. Biol. Chem. |volume=274 |issue= 21 |pages= 15262–70 |year= 1999 |pmid= 10329736 |doi=10.1074/jbc.274.21.15262 }}
*{{cite journal  | author=Hänze J, Berthold A, Klammt J, ''et al.'' |title=Cloning and sequencing of the complete cDNA encoding the human insulin receptor related receptor. |journal=Horm. Metab. Res. |volume=31 |issue= 2-3 |pages= 77-9 |year= 1999 |pmid= 10226785 |doi=  }}
*{{cite journal  | author=Elmlinger MW |title=Correlation of type I insulin-like growth factor receptor (IGF-I-R) and insulin receptor-related receptor (IRR) messenger RNA levels in tumor cell lines from pediatric tumors of neuronal origin |journal=Regul. Pept. |volume=84 |issue= 1–3 |pages= 37–42 |year= 1999 |pmid= 10535406 |doi=10.1016/S0167-0115(99)00065-8  |name-list-format=vanc| author2=Rauschnabel U  | author3=Koscielniak E  | display-authors=3  | last4=Haenze  | first4=J  | last5=Ranke  | first5=MB  | last6=Berthold  | first6=A  | last7=Klammt  | first7=J  | last8=Kiess  | first8=W }}
*{{cite journal  | author=Xu P, Jacobs AR, Taylor SI |title=Interaction of insulin receptor substrate 3 with insulin receptor, insulin receptor-related receptor, insulin-like growth factor-1 receptor, and downstream signaling proteins. |journal=J. Biol. Chem. |volume=274 |issue= 21 |pages= 15262-70 |year= 1999 |pmid= 10329736 |doi=  }}
*{{cite journal  | author=Whitmore TE |title=The assignment of the human insulin receptor-related receptor gene (INSRR) to chromosome 1q21→q23 by the use of radiation hybrid mapping |journal=Cytogenet. Cell Genet. |volume=87 |issue= 1–2 |pages= 93–4 |year= 2000 |pmid= 10640820 |doi=10.1159/000015400  |name-list-format=vanc| author2=Maurer MF  | author3=Day HL  | display-authors=3  | last4=Jelmberg  | first4=A.C.  | last5=Dasovich  | first5=M.M.  | last6=Sundborg  | first6=L.M.  | last7=Burkhead  | first7=S.K.  | last8=Heipel  | first8=M.D.  | last9=Madden  | first9=K.L. }}
*{{cite journal  | author=Elmlinger MW, Rauschnabel U, Koscielniak E, ''et al.'' |title=Correlation of type I insulin-like growth factor receptor (IGF-I-R) and insulin receptor-related receptor (IRR) messenger RNA levels in tumor cell lines from pediatric tumors of neuronal origin. |journal=Regul. Pept. |volume=84 |issue= 1-3 |pages= 37-42 |year= 1999 |pmid= 10535406 |doi=  }}
*{{cite journal  | author=Weber A |title=Coexpression of insulin receptor-related receptor and insulin-like growth factor 1 receptor correlates with enhanced apoptosis and dedifferentiation in human neuroblastomas |journal=Clin. Cancer Res. |volume=9 |issue= 15 |pages= 5683–92 |year= 2004 |pmid= 14654552 |doi= |name-list-format=vanc| author2=Huesken C  | author3=Bergmann E  | display-authors=3  | last4=Kiess  | first4=W  | last5=Christiansen  | first5=NM  | last6=Christiansen  | first6=H }}
*{{cite journal  | author=Whitmore TE, Maurer MF, Day HL, ''et al.'' |title=The assignment of the human insulin receptor-related receptor gene (INSRR) to chromosome 1q21-->q23 by the use of radiation hybrid mapping. |journal=Cytogenet. Cell Genet. |volume=87 |issue= 1-2 |pages= 93-4 |year= 2000 |pmid= 10640820 |doi=  }}
*{{cite journal  | author=Klammt J |title=Comparative analysis of the signaling capabilities of the insulin receptor-related receptor |journal=Biochem. Biophys. Res. Commun. |volume=327 |issue= 2 |pages= 557–64 |year= 2005 |pmid= 15629149 |doi= 10.1016/j.bbrc.2004.12.039 |name-list-format=vanc| author2=Garten A  | author3=Barnikol-Oettler A  | display-authors=3  | last4=Beck-Sickinger  | first4=Annette G.  | last5=Kiess  | first5=Wieland }}
*{{cite journal  | author=Weber A, Huesken C, Bergmann E, ''et al.'' |title=Coexpression of insulin receptor-related receptor and insulin-like growth factor 1 receptor correlates with enhanced apoptosis and dedifferentiation in human neuroblastomas. |journal=Clin. Cancer Res. |volume=9 |issue= 15 |pages= 5683-92 |year= 2004 |pmid= 14654552 |doi=  }}
*{{cite journal  | author=Dissen GA |title=Expression of the insulin receptor-related receptor is induced by the preovulatory surge of luteinizing hormone in thecal-interstitial cells of the rat ovary |journal=Endocrinology |volume=147 |issue= 1 |pages= 155–65 |year= 2006 |pmid= 16195402 |doi= 10.1210/en.2005-0386 |name-list-format=vanc| author2=Garcia-Rudaz C  | author3=Tapia V  | display-authors=3  | last4=Parada  | first4=LF  | last5=Hsu  | first5=SY  | last6=Ojeda  | first6=SR }}
*{{cite journal  | author=Klammt J, Garten A, Barnikol-Oettler A, ''et al.'' |title=Comparative analysis of the signaling capabilities of the insulin receptor-related receptor. |journal=Biochem. Biophys. Res. Commun. |volume=327 |issue= 2 |pages= 557-64 |year= 2005 |pmid= 15629149 |doi= 10.1016/j.bbrc.2004.12.039 }}
*{{cite journal  | author=Dissen GA, Garcia-Rudaz C, Tapia V, ''et al.'' |title=Expression of the insulin receptor-related receptor is induced by the preovulatory surge of luteinizing hormone in thecal-interstitial cells of the rat ovary. |journal=Endocrinology |volume=147 |issue= 1 |pages= 155-65 |year= 2006 |pmid= 16195402 |doi= 10.1210/en.2005-0386 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Tyrosine kinases}}
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[[Category:Tyrosine kinase receptors]]
 
 
{{gene-1-stub}}

Latest revision as of 02:35, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

n/a

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Insulin receptor-related protein is a protein that in humans is encoded by the INSRR gene.[1][2][3]


References

  1. ↑ Shier P, Watt VM (Oct 1989). "Primary structure of a putative receptor for a ligand of the insulin family". J Biol Chem. 264 (25): 14605–8. PMID 2768234.
  2. ↑ Shier P, Willard HF, Watt VM (Jan 1991). "Localization of the insulin receptor-related receptor gene to human chromosome 1". Cytogenet Cell Genet. 54 (1–2): 80–1. doi:10.1159/000132963. PMID 2249481.
  3. ↑ "Entrez Gene: INSRR insulin receptor-related receptor".

Further reading

  • Zhang B, Roth RA (1992). "The insulin receptor-related receptor. Tissue expression, ligand binding specificity, and signaling capabilities". J. Biol. Chem. 267 (26): 18320–8. PMID 1326521.
  • Mathi SK, Chan J, Watt VM (1995). "Insulin receptor-related receptor messenger ribonucleic acid: quantitative distribution and localization to subpopulations of epithelial cells in stomach and kidney". Endocrinology. 136 (9): 4125–32. doi:10.1210/en.136.9.4125. PMID 7649121.
  • Kovacina KS, Roth RA (1995). "Characterization of the endogenous insulin receptor-related receptor in neuroblastomas". J. Biol. Chem. 270 (4): 1881–7. doi:10.1074/jbc.270.4.1881. PMID 7829525.
  • Jui HY, Accili D, Taylor SI (1996). "Characterization of a hybrid receptor formed by dimerization of the insulin receptor-related receptor (IRR) with the insulin receptor (IR): coexpression of cDNAs encoding human IRR and human IR in NIH-3T3 cells". Biochemistry. 35 (45): 14326–30. doi:10.1021/bi9613032. PMID 8916919.
  • Hänze J, Berthold A, Klammt J, et al. (1999). "Cloning and sequencing of the complete cDNA encoding the human insulin receptor related receptor". Horm. Metab. Res. 31 (2–3): 77–9. doi:10.1055/s-2007-978702. PMID 10226785.
  • Xu P, Jacobs AR, Taylor SI (1999). "Interaction of insulin receptor substrate 3 with insulin receptor, insulin receptor-related receptor, insulin-like growth factor-1 receptor, and downstream signaling proteins". J. Biol. Chem. 274 (21): 15262–70. doi:10.1074/jbc.274.21.15262. PMID 10329736.
  • Elmlinger MW, Rauschnabel U, Koscielniak E, et al. (1999). "Correlation of type I insulin-like growth factor receptor (IGF-I-R) and insulin receptor-related receptor (IRR) messenger RNA levels in tumor cell lines from pediatric tumors of neuronal origin". Regul. Pept. 84 (1–3): 37–42. doi:10.1016/S0167-0115(99)00065-8. PMID 10535406.
  • Whitmore TE, Maurer MF, Day HL, et al. (2000). "The assignment of the human insulin receptor-related receptor gene (INSRR) to chromosome 1q21→q23 by the use of radiation hybrid mapping". Cytogenet. Cell Genet. 87 (1–2): 93–4. doi:10.1159/000015400. PMID 10640820.
  • Weber A, Huesken C, Bergmann E, et al. (2004). "Coexpression of insulin receptor-related receptor and insulin-like growth factor 1 receptor correlates with enhanced apoptosis and dedifferentiation in human neuroblastomas". Clin. Cancer Res. 9 (15): 5683–92. PMID 14654552.
  • Klammt J, Garten A, Barnikol-Oettler A, et al. (2005). "Comparative analysis of the signaling capabilities of the insulin receptor-related receptor". Biochem. Biophys. Res. Commun. 327 (2): 557–64. doi:10.1016/j.bbrc.2004.12.039. PMID 15629149.
  • Dissen GA, Garcia-Rudaz C, Tapia V, et al. (2006). "Expression of the insulin receptor-related receptor is induced by the preovulatory surge of luteinizing hormone in thecal-interstitial cells of the rat ovary". Endocrinology. 147 (1): 155–65. doi:10.1210/en.2005-0386. PMID 16195402.


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