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{{Infobox_gene}}
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'''Neuroserpin''' is a [[protein]] that in humans is encoded by the ''SERPINI1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5274| accessdate = }}</ref>
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It is associated with [[Familial encephalopathy with neuroserpin inclusion bodies]].
{{GNF_Protein_box
| image = PBB_Protein_SERPINI1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1jjo.
| PDB = {{PDB2|1jjo}}
| Name = Serpin peptidase inhibitor, clade I (neuroserpin), member 1
| HGNCid = 8943
| Symbol = SERPINI1
| AltSymbols =; DKFZp781N13156; PI12; neuroserpin
| OMIM = 602445
| ECnumber = 
| Homologene = 21045
| MGIid = 1194506
| GeneAtlas_image1 = PBB_GE_SERPINI1_205352_at_tn.png
| Function = {{GNF_GO|id=GO:0004867 |text = serine-type endopeptidase inhibitor activity}}
| Component =
| Process = {{GNF_GO|id=GO:0007417 |text = central nervous system development}} {{GNF_GO|id=GO:0007422 |text = peripheral nervous system development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5274
    | Hs_Ensembl = ENSG00000163536
    | Hs_RefseqProtein = NP_005016
    | Hs_RefseqmRNA = NM_005025
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 168936205
    | Hs_GenLoc_end = 169026042
    | Hs_Uniprot = Q99574
    | Mm_EntrezGene = 20713
    | Mm_Ensembl = ENSMUSG00000027834
    | Mm_RefseqmRNA = NM_009250
    | Mm_RefseqProtein = NP_033276
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 75643474
    | Mm_GenLoc_end = 75729422
    | Mm_Uniprot = O35684
  }}
}}
'''Serpin peptidase inhibitor, clade I (neuroserpin), member 1''', also known as '''SERPINI1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5274| accessdate = }}</ref>


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{{PBB_Summary
{{PBB Summary
| section_title =  
| section_title =  
| summary_text = Serine protease inhibitors of the serpin superfamily are involved in many cellular processes. Neuroserpin was first identified as a protein secreted from the axons of dorsal root ganglion neurons (Stoeckli et al., 1989). It is expressed in the late stages of neurogenesis during the process of synapse formation.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5274| accessdate = }}</ref>
| summary_text = Serine protease inhibitors of the [[serpin]] superfamily are involved in many cellular processes. Neuroserpin was first identified as a protein secreted from the axons of dorsal root ganglion neurons (Stoeckli et al., 1989). It is expressed in the late stages of neurogenesis during the process of synapse formation.[supplied by OMIM]<ref name="entrez"/>
}}
}}
==Interactions==
SERPINI1 has been shown to [[Protein-protein interaction|interact]] with [[Tissue plasminogen activator]].<ref name=pmid12354288>{{cite journal |last=Parmar |first=Parmjeet K |authorlink= |author2=Coates Leigh C |author3=Pearson John F |author4=Hill Rena M |author5=Birch Nigel P  |date=September 2002  |title=Neuroserpin regulates neurite outgrowth in nerve growth factor-treated PC12 cells |journal=J. Neurochem. |volume=82 |issue=6 |pages=1406–15 |publisher= |location = England| issn = 0022-3042| pmid = 12354288 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1046/j.1471-4159.2002.01100.x }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Yepes M, Lawrence DA |title=Neuroserpin: a selective inhibitor of tissue-type plasminogen activator in the central nervous system. |journal=Thromb. Haemost. |volume=91 |issue= 3 |pages= 457-64 |year= 2004 |pmid= 14983220 |doi= 10.1160/TH03-12-0766 }}
*{{cite journal  |author1=Yepes M |author2=Lawrence DA |title=Neuroserpin: a selective inhibitor of tissue-type plasminogen activator in the central nervous system. |journal=Thromb. Haemost. |volume=91 |issue= 3 |pages= 457–64 |year= 2004 |pmid= 14983220 |doi= 10.1160/TH03-12-0766 }}
*{{cite journal | author=Schrimpf SP, Bleiker AJ, Brecevic L, ''et al.'' |title=Human neuroserpin (PI12): cDNA cloning and chromosomal localization to 3q26. |journal=Genomics |volume=40 |issue= 1 |pages= 55-62 |year= 1997 |pmid= 9070919 |doi= 10.1006/geno.1996.4514 }}
*{{cite journal   |vauthors=Schrimpf SP, Bleiker AJ, Brecevic L, etal |title=Human neuroserpin (PI12): cDNA cloning and chromosomal localization to 3q26. |journal=Genomics |volume=40 |issue= 1 |pages= 55–62 |year= 1997 |pmid= 9070919 |doi= 10.1006/geno.1996.4514 }}
*{{cite journal | author=Hastings GA, Coleman TA, Haudenschild CC, ''et al.'' |title=Neuroserpin, a brain-associated inhibitor of tissue plasminogen activator is localized primarily in neurons. Implications for the regulation of motor learning and neuronal survival. |journal=J. Biol. Chem. |volume=272 |issue= 52 |pages= 33062-7 |year= 1998 |pmid= 9407089 |doi=  }}
*{{cite journal   |vauthors=Hastings GA, Coleman TA, Haudenschild CC, etal |title=Neuroserpin, a brain-associated inhibitor of tissue plasminogen activator is localized primarily in neurons. Implications for the regulation of motor learning and neuronal survival. |journal=J. Biol. Chem. |volume=272 |issue= 52 |pages= 33062–7 |year= 1998 |pmid= 9407089 |doi=10.1074/jbc.272.52.33062 }}
*{{cite journal | author=Davis RL, Shrimpton AE, Holohan PD, ''et al.'' |title=Familial dementia caused by polymerization of mutant neuroserpin. |journal=Nature |volume=401 |issue= 6751 |pages= 376-9 |year= 1999 |pmid= 10517635 |doi= 10.1038/43894 }}
*{{cite journal   |vauthors=Davis RL, Shrimpton AE, Holohan PD, etal |title=Familial dementia caused by polymerization of mutant neuroserpin. |journal=Nature |volume=401 |issue= 6751 |pages= 376–9 |year= 1999 |pmid= 10517635 |doi= 10.1038/43894 }}
*{{cite journal | author=Chang WS, Chang NT, Lin SC, ''et al.'' |title=Tissue-specific cancer-related serpin gene cluster at human chromosome band 3q26. |journal=Genes Chromosomes Cancer |volume=29 |issue= 3 |pages= 240-55 |year= 2000 |pmid= 10992299 |doi=  }}
*{{cite journal   |vauthors=Chang WS, Chang NT, Lin SC, etal |title=Tissue-specific cancer-related serpin gene cluster at human chromosome band 3q26. |journal=Genes Chromosomes Cancer |volume=29 |issue= 3 |pages= 240–55 |year= 2000 |pmid= 10992299 |doi=10.1002/1098-2264(2000)9999:9999<::AID-GCC1029>3.0.CO;2-A }}
*{{cite journal  | author=Belorgey D, Crowther DC, Mahadeva R, Lomas DA |title=Mutant Neuroserpin (S49P) that causes familial encephalopathy with neuroserpin inclusion bodies is a poor proteinase inhibitor and readily forms polymers in vitro. |journal=J. Biol. Chem. |volume=277 |issue= 19 |pages= 17367-73 |year= 2002 |pmid= 11880376 |doi= 10.1074/jbc.M200680200 }}
*{{cite journal  |author1=Belorgey D |author2=Crowther DC |author3=Mahadeva R |author4=Lomas DA |title=Mutant Neuroserpin (S49P) that causes familial encephalopathy with neuroserpin inclusion bodies is a poor proteinase inhibitor and readily forms polymers in vitro. |journal=J. Biol. Chem. |volume=277 |issue= 19 |pages= 17367–73 |year= 2002 |pmid= 11880376 |doi= 10.1074/jbc.M200680200 }}
*{{cite journal | author=Davis RL, Shrimpton AE, Carrell RW, ''et al.'' |title=Association between conformational mutations in neuroserpin and onset and severity of dementia. |journal=Lancet |volume=359 |issue= 9325 |pages= 2242-7 |year= 2002 |pmid= 12103288 |doi=  }}
*{{cite journal   |vauthors=Davis RL, Shrimpton AE, Carrell RW, etal |title=Association between conformational mutations in neuroserpin and onset and severity of dementia. |journal=Lancet |volume=359 |issue= 9325 |pages= 2242–7 |year= 2002 |pmid= 12103288 |doi=10.1016/S0140-6736(02)09293-0 }}
*{{cite journal  | author=Barker-Carlson K, Lawrence DA, Schwartz BS |title=Acyl-enzyme complexes between tissue-type plasminogen activator and neuroserpin are short-lived in vitro. |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 46852-7 |year= 2003 |pmid= 12228252 |doi= 10.1074/jbc.M207740200 }}
*{{cite journal  |author1=Barker-Carlson K |author2=Lawrence DA |author3=Schwartz BS |title=Acyl-enzyme complexes between tissue-type plasminogen activator and neuroserpin are short-lived in vitro. |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 46852–7 |year= 2003 |pmid= 12228252 |doi= 10.1074/jbc.M207740200 }}
*{{cite journal | author=Parmar PK, Coates LC, Pearson JF, ''et al.'' |title=Neuroserpin regulates neurite outgrowth in nerve growth factor-treated PC12 cells. |journal=J. Neurochem. |volume=82 |issue= 6 |pages= 1406-15 |year= 2002 |pmid= 12354288 |doi= }}
*{{cite journal   |vauthors=Parmar PK, Coates LC, Pearson JF, etal |title=Neuroserpin regulates neurite outgrowth in nerve growth factor-treated PC12 cells. |journal=J. Neurochem. |volume=82 |issue= 6 |pages= 1406–15 |year= 2002 |pmid= 12354288 |doi=10.1046/j.1471-4159.2002.01100.x  }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Miranda E, Römisch K, Lomas DA |title=Mutants of neuroserpin that cause dementia accumulate as polymers within the endoplasmic reticulum. |journal=J. Biol. Chem. |volume=279 |issue= 27 |pages= 28283-91 |year= 2004 |pmid= 15090543 |doi= 10.1074/jbc.M313166200 }}
*{{cite journal  |author1=Miranda E |author2=Römisch K |author3=Lomas DA |title=Mutants of neuroserpin that cause dementia accumulate as polymers within the endoplasmic reticulum. |journal=J. Biol. Chem. |volume=279 |issue= 27 |pages= 28283–91 |year= 2004 |pmid= 15090543 |doi= 10.1074/jbc.M313166200 }}
*{{cite journal | author=Teesalu T, Kulla A, Simisker A, ''et al.'' |title=Tissue plasminogen activator and neuroserpin are widely expressed in the human central nervous system. |journal=Thromb. Haemost. |volume=92 |issue= 2 |pages= 358-68 |year= 2005 |pmid= 15269833 |doi= 10.1267/THRO04080358 }}
*{{cite journal   |vauthors=Teesalu T, Kulla A, Simisker A, etal |title=Tissue plasminogen activator and neuroserpin are widely expressed in the human central nervous system. |journal=Thromb. Haemost. |volume=92 |issue= 2 |pages= 358–68 |year= 2005 |pmid= 15269833 |doi= 10.1267/THRO04080358 }}
*{{cite journal | author=Belorgey D, Sharp LK, Crowther DC, ''et al.'' |title=Neuroserpin Portland (Ser52Arg) is trapped as an inactive intermediate that rapidly forms polymers: implications for the epilepsy seen in the dementia FENIB. |journal=Eur. J. Biochem. |volume=271 |issue= 16 |pages= 3360-7 |year= 2004 |pmid= 15291813 |doi= 10.1111/j.1432-1033.2004.04270.x }}
*{{cite journal   |vauthors=Belorgey D, Sharp LK, Crowther DC, etal |title=Neuroserpin Portland (Ser52Arg) is trapped as an inactive intermediate that rapidly forms polymers: implications for the epilepsy seen in the dementia FENIB. |journal=Eur. J. Biochem. |volume=271 |issue= 16 |pages= 3360–7 |year= 2004 |pmid= 15291813 |doi= 10.1111/j.1432-1033.2004.04270.x }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal  | author=Onda M, Belorgey D, Sharp LK, Lomas DA |title=Latent S49P neuroserpin forms polymers in the dementia familial encephalopathy with neuroserpin inclusion bodies. |journal=J. Biol. Chem. |volume=280 |issue= 14 |pages= 13735-41 |year= 2005 |pmid= 15664988 |doi= 10.1074/jbc.M413282200 }}
*{{cite journal  |author1=Onda M |author2=Belorgey D |author3=Sharp LK |author4=Lomas DA |title=Latent S49P neuroserpin forms polymers in the dementia familial encephalopathy with neuroserpin inclusion bodies. |journal=J. Biol. Chem. |volume=280 |issue= 14 |pages= 13735–41 |year= 2005 |pmid= 15664988 |doi= 10.1074/jbc.M413282200 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Kinghorn KJ, Crowther DC, Sharp LK, ''et al.'' |title=Neuroserpin binds Abeta and is a neuroprotective component of amyloid plaques in Alzheimer disease. |journal=J. Biol. Chem. |volume=281 |issue= 39 |pages= 29268-77 |year= 2006 |pmid= 16849336 |doi= 10.1074/jbc.M600690200 }}
*{{cite journal   |vauthors=Kinghorn KJ, Crowther DC, Sharp LK, etal |title=Neuroserpin binds Abeta and is a neuroprotective component of amyloid plaques in Alzheimer disease. |journal=J. Biol. Chem. |volume=281 |issue= 39 |pages= 29268–77 |year= 2006 |pmid= 16849336 |doi= 10.1074/jbc.M600690200 }}
*{{cite journal | author=Chen PY, Chang WS, Chou RH, ''et al.'' |title=Two non-homologous brain diseases-related genes, SERPINI1 and PDCD10, are tightly linked by an asymmetric bidirectional promoter in an evolutionarily conserved manner. |journal=BMC Mol. Biol. |volume=8 |issue=  |pages= 2 |year= 2007 |pmid= 17212813 |doi= 10.1186/1471-2199-8-2 }}
*{{cite journal   |vauthors=Chen PY, Chang WS, Chou RH, etal |title=Two non-homologous brain diseases-related genes, SERPINI1 and PDCD10, are tightly linked by an asymmetric bidirectional promoter in an evolutionarily conserved manner. |journal=BMC Mol. Biol. |volume=8 |issue=  |pages= 2 |year= 2007 |pmid= 17212813 |doi= 10.1186/1471-2199-8-2 | pmc=1796892 }}
*{{cite journal | author=Gourfinkel-An I, Duyckaerts C, Camuzat A, ''et al.'' |title=Clinical and neuropathologic study of a French family with a mutation in the neuroserpin gene. |journal=Neurology |volume=69 |issue= 1 |pages= 79-83 |year= 2007 |pmid= 17606885 |doi= 10.1212/01.wnl.0000265052.99144.b5 }}
*{{cite journal   |vauthors=Gourfinkel-An I, Duyckaerts C, Camuzat A, etal |title=Clinical and neuropathologic study of a French family with a mutation in the neuroserpin gene. |journal=Neurology |volume=69 |issue= 1 |pages= 79–83 |year= 2007 |pmid= 17606885 |doi= 10.1212/01.wnl.0000265052.99144.b5 }}
}}
}}
{{refend}}
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{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* The [[MEROPS]] online database for peptidases and their inhibitors: [http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=I04.025 I04.025]
{{PDB Gallery|geneid=5274}}
{{Serpins}}
 
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Revision as of 06:09, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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Wikidata
View/Edit Human

Neuroserpin is a protein that in humans is encoded by the SERPINI1 gene.[1]

It is associated with Familial encephalopathy with neuroserpin inclusion bodies.

Serine protease inhibitors of the serpin superfamily are involved in many cellular processes. Neuroserpin was first identified as a protein secreted from the axons of dorsal root ganglion neurons (Stoeckli et al., 1989). It is expressed in the late stages of neurogenesis during the process of synapse formation.[supplied by OMIM][1]

Interactions

SERPINI1 has been shown to interact with Tissue plasminogen activator.[2]

References

  1. ↑ 1.0 1.1 "Entrez Gene: SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1".
  2. ↑ Parmar, Parmjeet K; Coates Leigh C; Pearson John F; Hill Rena M; Birch Nigel P (September 2002). "Neuroserpin regulates neurite outgrowth in nerve growth factor-treated PC12 cells". J. Neurochem. England. 82 (6): 1406–15. doi:10.1046/j.1471-4159.2002.01100.x. ISSN 0022-3042. PMID 12354288.

Further reading

External links

  • The MEROPS online database for peptidases and their inhibitors: I04.025



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